Now showing items 31-40 of 167
Elucidation of Sorafenib resistance mechanisms in hepatocellular carcinoma
(Bilkent University, 2018-07)
Hepatocellular Carcinoma (HCC) is the sixth most common type of cancer and the second leading cause of cancer-related deaths worldwide. Currently, Sorafenib is the only approved first-line treatment option for unresectable ...
Identification of the role of p33ING1 protein in the cellular activities of p53 tumor suppressor protein
(Bilkent University, 1999)
p53 is a tumor suppressor gene which is mutated in about 50% of human cancers. The product of p53 gene encodes a sequence-specific transcription factor. The genes are transactivated by p53 code for proteins that are ...
Contribution of notch signaling on HCC stem cell status and utilizing TLR agonists and notch inhibition to improve HCC theraphy
(Bilkent University, 2014)
Hepatocellular carcinoma (HCC) is the seventh most common cancer type worldwide, and ranked third place among cancer-related deaths within both sexes. As in many solid tumors, HCC shelters a cancer stem cell subpopulation, ...
Development & characterization of CpG adjuvanted SARS-CoV-2 Virus-Like Particle vaccine
(Bilkent University, 2022-06)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared in late 2019, led to countless cases and deaths and eventually regarded as one of the severe pandemics of modern times. To reduce hospitalization and ...
NF1 mutation analysis in a child homozygous for MLH1 mutation
(Bilkent University, 1999)
Role of FAM134B in liver cancer
(Bilkent University, 2013)
The family with sequence similarity 134, member B (FAM134B) protein initially caught attention in our laboratory through demonstrating elevated levels possibly associated with senescent, cirrhotic, and mesenchymal-like ...
Characterization of FAM134B in the context of hepatocellular carcinoma and endoplasmic reticulum protein stress
(Bilkent University, 2011)
Family with sequence similarity 134, member B (FAM134B) is a replicative senescence associated gene, previously identified in studies of our group as a result of microarray analysis in spontaneously senescent clones of ...
Targeting adenosine receptors to improve vaccine efficacy
(Bilkent University, 2016-12)
Vaccination is the major protection method against many diseases caused by pathogens through creating acquired immunity. Vaccines can be classified in two major groups, which are subunit vaccines and attenuated vaccines. ...
Investigation of the role of cGAMP in differentiation of T lymphocytes
(Bilkent University, 2016-10)
STING is the pivotal mediator for the recognition of host and pathogenic cytosolic dsDNA as well as cyclic di-nucleotides metabolites from microbes. STING can either recognize DNA itself or sense the presence of cGAMP, ...
Reconstitution of the partial tail module of the human mediator complex
(Bilkent University, 2021-09)
RNA Polymerase II (Pol II) regulates and maintains every aspect of the cell through the act of transcription of protein coding genes. Transcription of protein coding genes depends on extrinsic and intrinsic signals to the ...