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Now showing items 11-20 of 167
Identification of the fibrogenic cells in the liver
(Bilkent University, 2022-03)
The liver is an important multitasking organ with diverse functions to maintain body
homeostasis. Adjustment of glucose level, detoxification, secretion of blood proteins, and
synthesis of bile acids are the among these ...
Identifying TBK1-specific roles in colorectal cancer
(Bilkent University, 2022-06)
Colorectal cancer (CRC) is the second most lethal cancer type, with a high incidence rate among adults. The CRC is a highly heterogenic disease with a high rate of mutations in different molecular pathways. Moreover, ...
BRCA:Cohort-vs-TCGA: a webtool for comprehensive exploration and comparison of mutational landscape of breast cancer cohorts with TCGA-BRCA
(Bilkent University, 2022-08)
Comparisons of mutational landscapes between independent breast cancer (BRCA) cohorts in a comprehensive and statistical manner using online tools are likely to help advance our understanding of the diversity of somatic ...
Transcript variants of CELF2 gene as unique prognostic indicators in breast cancer
(Bilkent University, 2022-08)
Breast cancer (BC) is the most common malignant tumor in women around the world. Aside from finding a cure for this disease, it is also critical to identify prognostic biomarkers that can help clinicians intervene with the ...
Development and validation of methods for the diagnosis of lung cancer via serological biomarkers
(Bilkent University, 2019-02)
Over 10% of all new cancer cases are lung cancer. Moreover, estimates till 2030 indicate that already increasing lung cancer incidences will keep increasing, especially in developing countries like Turkey. Lung cancer, the ...
Investigation of immune impairment status in primary immune deficiency and spinal cord injury
(Bilkent University, 2021-02)
Primary Immunodeficiencies (PIDs) are raised by immune impairment causing disorders. In the patients carrying deficiency in any part of immune system, various defects and symptoms are observed. Generally, abnormality against ...
The effect of interleukin 7 on CD8+T cell accumulation and differentiation in the presence of adenosine signaling
(Bilkent University, 2020-01)
Cytotoxic T cells are important cytotoxic adaptive immune cells. Their role is to check every single cell for protecting the body against microbial infections. They are also the main players for antigen-specific recognition ...
In silico validation of prognostic mRNA signature in gastric cancer and identification and validation of novel gastric tissue specific reference genes for quantitative PCR
(Bilkent University, 2021-07)
Gastric adenocarcinoma is a molecularly and histologically heterogeneous neoplasm with a predictively disastrous outcome if undiagnosed at early stages. Amidst global declines of gastric cancer rates, it remains the 5th ...
Mirna based identification of prostate cancer by investigation of urinary exosomes
(Bilkent University, 2020-08)
Prostate cancer is one of the most incident cancer subtypes with high mortality rate. Currently, diagnosis of prostate cancer is based on rectal examination, Prostate Specific Antigen (PSA) testing and biopsy. Normal range ...
Molecular mechanism for adenosine regulation of dendritic cells
(Bilkent University, 2017-05)
Cell death, inflammation or other cellular stress factors cause accumulation of adenosine in the extracellular space. Adenosine has immunosuppressive effects on antigen presenting cells. However, molecular mechanisms for ...