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Molecular mechanisms of PI3K isoform dependence in carcinogenesis
(Bilkent University, 2020-12)
PI3K pathway is important for cellular proliferation, survival and metabolism. PTENloss and activating mutations of PIK3CA are most frequently seen PI3K related
alterations in various cancer types. Activating mutations ...
Systems biology approach for targeted therapy of liver cancer P13K/AKT/MTOR pathway inhibitors : an ally or rival for sorafenib'e
(Bilkent University, 2014)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancerrelated
mortality worldwide. It is the second most frequent cause of cancer death in
men, and the sixth in women due to its aggressive behavior and ...
Investigation of PI3K functional compensation VIA activated tyrosine kinases
(Bilkent University, 2020-12)
Protein tyrosine kinases and serine-threonine kinases have crucial functions in cell
signaling, differentiation, motility, and proliferation. PI3K is the most deregulated
pathway in human cancers and an essential regulator ...
Targeted metabolomics revealed a key metabolic reprogramming in cholesterol biosynthesis pathway upon PTEN re-expression in PTEN-null, metastatic and castration-resistant prostate cancer
(Bilkent University, 2022-06)
Prostate cancer is the second most diagnosed type of cancer in males worldwide. Androgen signaling is a main driver of prostate cancers progression and androgen-deprivation therapies (ADT) are remained to be main treatment ...
Identification and targeting of deregulated metabolic pathways in metastatic prostate cancer cells
(Bilkent University, 2023-01)
Prostate cancer is the most diagnosed cancer type and the second leading cause of death in men globally. The pathogenesis of prostate cancer mainly relies on the androgen signaling axis. Therefore, androgen deprivation ...