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Deciphering IKBKE involvement in hepatocellular cancer HEPG2 cells
(Bilkent University, 2020-06)
Hepatocellular carcinoma (HCC) is the second leading cause of cancer related deaths worldwide. The reasons behind high mortality in HCC patients include late diagnosis and lack of therapeutic option. Sorafenib is the only ...
Elucidation of Sorafenib resistance mechanisms in hepatocellular carcinoma
(Bilkent University, 2018-07)
Hepatocellular Carcinoma (HCC) is the sixth most common type of cancer and the second leading cause of cancer-related deaths worldwide. Currently, Sorafenib is the only approved first-line treatment option for unresectable ...
Immunomodulatory effects of exosomes: promising candidates in immunotherapy
(Bilkent University, 2018-08)
Exosomes are type of extracellular vesicles secreted from almost all cell types and
carry numerous biological molecules such as nucleic acids, protein and lipids. They
mediate many cellular processes including cellular ...
Identification of the roles played by IKKε in hepatocellular and colorectal carcinogenesis
(Bilkent University, 2018-07)
Hepatocellular carcinomas (HCC) and colorectal carcinomas (CRC) are among the most common cancers worldwide with high mortality rates. While HCC affecting mostly underdeveloped countries, CRC is a disease that mainly occur ...
Genetic analysis of Smad4 gene in TGF-Beta signalling pathway in human liver cancer
(Bilkent University, 1998)
HCC is a multistep genetic disease in which many genomic changes occur as a result of
uncontrolled proliferation of hepatocytes. Molecular events leading to HCC is still
unclear. Until now, neither an oncogene nor a tumor ...
Identification of genes involved in hepatocellular carcinoma : evaluation of hCdc4 and B-Raf genes
(Bilkent University, 2003)
Hepatocellular carcinoma (HCC), the major type of primary liver cancer, is one of the
most common cancers worldwide. Development and progression of HCC occur as a
multistep process, requiring the activation of oncogenes ...