Now showing items 1-5 of 5
Analysis of the ATAD2 gene effect on the genes involved in epithelial mesenchymal transition in estrogen positive and negative breast cancers
(Bilkent University, 2021-02)
ATAD2 is overexpressed in many distinct cancer types including breast cancer. Its elevated expression is an indicator of poor prognosis. High ATAD2 expression correlates with short overall survival, disease-free survival ...
Deciphering IKBKE involvement in hepatocellular cancer HEPG2 cells
(Bilkent University, 2020-06)
Hepatocellular carcinoma (HCC) is the second leading cause of cancer related deaths worldwide. The reasons behind high mortality in HCC patients include late diagnosis and lack of therapeutic option. Sorafenib is the only ...
Identifying TBK1-specific roles in colorectal cancer
(Bilkent University, 2022-06)
Colorectal cancer (CRC) is the second most lethal cancer type, with a high incidence rate among adults. The CRC is a highly heterogenic disease with a high rate of mutations in different molecular pathways. Moreover, ...
Identification of the roles played by IKKε in hepatocellular and colorectal carcinogenesis
(Bilkent University, 2018-07)
Hepatocellular carcinomas (HCC) and colorectal carcinomas (CRC) are among the most common cancers worldwide with high mortality rates. While HCC affecting mostly underdeveloped countries, CRC is a disease that mainly occur ...
Analysis of the effect of Erbin on the epithelial to mesenchymal transition related genes in breast cancer
(Bilkent University, 2022-09)
Breast cancer is a heterogeneous disease and has complex mechanisms, which brings the need to come up with different approaches for its various types. Erbin is a member of the LAP family and directly interacts with ErbB2 ...