Now showing items 1-5 of 5
Effects of miR-376 family miRNAs on CHRNA5 depleted MCF7 cell line model and co-culture competition studies
(Bilkent University, 2019-07)
Cholinergic receptor nicotinic alpha 5 (CHRNA5) is a ligand-gated ion channel and one of the subunits of nicotinic acetylcholine receptors. Role of CHRNA5 in tumorigenesis has been initially shown in the lung tissue in ...
qPCR validation of in vivo diagnostic importance and regulation by estrogen for CHRNA5 isoform expression in breast cancer
(Bilkent University, 2014)
Breast cancer has multiple molecular subtypes; normal-like, basal-like, luminal A, luminal B and HER2 positive depending on receptor status of tumor cells. Cancer therapy is tailored according to the type of cancer; hence ...
Analysis of CHRNA5 expression in breast cancer cell lines in response to serum starvation and estrogen treatment
(Bilkent University, 2013)
Breast cancer is a complex disease that can be classified into distinct molecular subtypes including Basal, Luminal A, Luminal B and HER2 positive. These molecular subtypes mainly differ in their hormone receptor ...
hsa-miR-497 as a modulator of the expression in the presence or absence of chrna5 in breast cancer
(Bilkent University, 2017-06)
CHRNA5 is an important ligand-gated receptor with roles in addiction and in cancer. In lung cancer, CHRNA5 dysregulation is well known. There is also expression of CHRNA5 in breast cancer cell lines. microRNAs regulate ...
Effects of depletion of CHRNA5 and/or TP53, and transient and stable overexpression of wildtype or mutant TP53 on expression of DLK1-MEG3 locus in MCF7 cells
(Bilkent University, 2022-09)
The expression of CHRNA5 has a prominent role in lung cancer and nicotine addiction. Besides, depletion of CHRNA5 has been identified as being tumour suppressive in breast cancer. Moreover, CHRNA5 depletion causes increases ...