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miRNA-mRNA interaction network regulating chemotherapy resistance in triple negative breast cancer
(Bilkent University, 2019-06)
Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, lacking the expression of the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). ...
Immunomodulatory potential of human umbilical cord tissue-derived mesenchymal stromal cell (UCX®) exosomes in combination with immunosuppressive “A151” oligodeoxynucleotide
(Bilkent University, 2019-07)
Mesenchymal stromal or stem cells (MSCs) modulate immune responses apart from their regenerative capacities. Accumulating evidence suggests that MSCs exert their paracrine effects through extracellular vesicles known as ...
Molecular mechanisms of PI3K isoform dependence in carcinogenesis
(Bilkent University, 2020-12)
PI3K pathway is important for cellular proliferation, survival and metabolism. PTENloss and activating mutations of PIK3CA are most frequently seen PI3K related
alterations in various cancer types. Activating mutations ...
Investigation of resistance mechanisms in response to PIK3CA inhibition in breast cancer
(Bilkent University, 2020-12)
Breast cancer is the most frequently diagnosed cancer type, accounting for 25% of
total cancer cases. PI3K pathway is the most deregulated pathway in breast cancer.
Therefore, many inhibitors have been developed for ...
Analysis of the ATAD2 gene effect on the genes involved in epithelial mesenchymal transition in estrogen positive and negative breast cancers
(Bilkent University, 2021-02)
ATAD2 is overexpressed in many distinct cancer types including breast cancer. Its elevated expression is an indicator of poor prognosis. High ATAD2 expression correlates with short overall survival, disease-free survival ...
Effects of miR-376 family miRNAs on CHRNA5 depleted MCF7 cell line model and co-culture competition studies
(Bilkent University, 2019-07)
Cholinergic receptor nicotinic alpha 5 (CHRNA5) is a ligand-gated ion channel and one
of the subunits of nicotinic acetylcholine receptors. Role of CHRNA5 in tumorigenesis has
been initially shown in the lung tissue in ...
Deciphering IKBKE involvement in hepatocellular cancer HEPG2 cells
(Bilkent University, 2020-06)
Hepatocellular carcinoma (HCC) is the second leading cause of cancer related deaths worldwide. The reasons behind high mortality in HCC patients include late diagnosis and lack of therapeutic option. Sorafenib is the only ...
Therapeutic potential of an immunosuppressive oligodeoxynucleotide encapsulated within liposomes on bleomycin-induced mouse model of lung inflammation and fibrosis
(Bilkent University, 2019-05)
Systemic sclerosis (SSc) is an autoimmune/autoinflammatory disease with unknown etiology. It is characterized by vascular dysfunction, inflammation and disseminated fibrosis of skin or internal organs. Although its prevalence ...
The primary cilia of the gastrointestinal tract in homeostasis and disease at the single-cell level
(Bilkent University, 2021-07)
The gastrointestinal tract is regularly renewed by stem cells which divide and differentiate into functionally and morphologically distinct cell types. Several key pathways, such as Wnt, Hedgehog and Bmp, regulate the cell ...
Class IA PI3K isoforms lead to differential signaling downstream of PKB/AKT
(Bilkent University, 2020-12)
PI3K pathway has been deregulated in one third of human cancers. All Class IA PI3Ks,
which are composed of catalytic and regulatory subunits, catalyze convertion of PIP2 to
PIP3 on plasma membrane. The catalytic subunits ...