Search
Now showing items 1-10 of 38
Molecular mechanisms of PI3K isoform dependence in carcinogenesis
(Bilkent University, 2020-12)
PI3K pathway is important for cellular proliferation, survival and metabolism. PTENloss and activating mutations of PIK3CA are most frequently seen PI3K related
alterations in various cancer types. Activating mutations ...
Investigation of resistance mechanisms in response to PIK3CA inhibition in breast cancer
(Bilkent University, 2020-12)
Breast cancer is the most frequently diagnosed cancer type, accounting for 25% of
total cancer cases. PI3K pathway is the most deregulated pathway in breast cancer.
Therefore, many inhibitors have been developed for ...
Analysis of the ATAD2 gene effect on the genes involved in epithelial mesenchymal transition in estrogen positive and negative breast cancers
(Bilkent University, 2021-02)
ATAD2 is overexpressed in many distinct cancer types including breast cancer. Its elevated expression is an indicator of poor prognosis. High ATAD2 expression correlates with short overall survival, disease-free survival ...
Deciphering IKBKE involvement in hepatocellular cancer HEPG2 cells
(Bilkent University, 2020-06)
Hepatocellular carcinoma (HCC) is the second leading cause of cancer related deaths worldwide. The reasons behind high mortality in HCC patients include late diagnosis and lack of therapeutic option. Sorafenib is the only ...
The primary cilia of the gastrointestinal tract in homeostasis and disease at the single-cell level
(Bilkent University, 2021-07)
The gastrointestinal tract is regularly renewed by stem cells which divide and differentiate into functionally and morphologically distinct cell types. Several key pathways, such as Wnt, Hedgehog and Bmp, regulate the cell ...
Class IA PI3K isoforms lead to differential signaling downstream of PKB/AKT
(Bilkent University, 2020-12)
PI3K pathway has been deregulated in one third of human cancers. All Class IA PI3Ks,
which are composed of catalytic and regulatory subunits, catalyze convertion of PIP2 to
PIP3 on plasma membrane. The catalytic subunits ...
Identification of the fibrogenic cells in the liver
(Bilkent University, 2022-03)
The liver is an important multitasking organ with diverse functions to maintain body
homeostasis. Adjustment of glucose level, detoxification, secretion of blood proteins, and
synthesis of bile acids are the among these ...
Identifying TBK1-specific roles in colorectal cancer
(Bilkent University, 2022-06)
Colorectal cancer (CRC) is the second most lethal cancer type, with a high incidence rate among adults. The CRC is a highly heterogenic disease with a high rate of mutations in different molecular pathways. Moreover, ...
BRCA:Cohort-vs-TCGA: a webtool for comprehensive exploration and comparison of mutational landscape of breast cancer cohorts with TCGA-BRCA
(Bilkent University, 2022-08)
Comparisons of mutational landscapes between independent breast cancer (BRCA) cohorts in a comprehensive and statistical manner using online tools are likely to help advance our understanding of the diversity of somatic ...
Transcript variants of CELF2 gene as unique prognostic indicators in breast cancer
(Bilkent University, 2022-08)
Breast cancer (BC) is the most common malignant tumor in women around the world. Aside from finding a cure for this disease, it is also critical to identify prognostic biomarkers that can help clinicians intervene with the ...