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miRNA-mRNA interaction network regulating chemotherapy resistance in triple negative breast cancer
(Bilkent University, 2019-06)
Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, lacking the expression of the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). ...
Immunomodulatory potential of human umbilical cord tissue-derived mesenchymal stromal cell (UCX®) exosomes in combination with immunosuppressive “A151” oligodeoxynucleotide
(Bilkent University, 2019-07)
Mesenchymal stromal or stem cells (MSCs) modulate immune responses apart from their regenerative capacities. Accumulating evidence suggests that MSCs exert their paracrine effects through extracellular vesicles known as ...
Effects of miR-376 family miRNAs on CHRNA5 depleted MCF7 cell line model and co-culture competition studies
(Bilkent University, 2019-07)
Cholinergic receptor nicotinic alpha 5 (CHRNA5) is a ligand-gated ion channel and one
of the subunits of nicotinic acetylcholine receptors. Role of CHRNA5 in tumorigenesis has
been initially shown in the lung tissue in ...
Therapeutic potential of an immunosuppressive oligodeoxynucleotide encapsulated within liposomes on bleomycin-induced mouse model of lung inflammation and fibrosis
(Bilkent University, 2019-05)
Systemic sclerosis (SSc) is an autoimmune/autoinflammatory disease with unknown etiology. It is characterized by vascular dysfunction, inflammation and disseminated fibrosis of skin or internal organs. Although its prevalence ...
Development and validation of methods for the diagnosis of lung cancer via serological biomarkers
(Bilkent University, 2019-02)
Over 10% of all new cancer cases are lung cancer. Moreover, estimates till 2030 indicate that already increasing lung cancer incidences will keep increasing, especially in developing countries like Turkey. Lung cancer, the ...
Molecular mechanism for adenosine regulation of dendritic cells
(Bilkent University, 2017-05)
Cell death, inflammation or other cellular stress factors cause accumulation of adenosine in the extracellular space. Adenosine has immunosuppressive effects on antigen presenting cells. However, molecular mechanisms for ...
Effects of biological compound Turkish propolis extract on breast cancer cells
(Bilkent University, 2013)
Propolis is a resinous compound which is collected from various plants then
combined with wax and bee enzymes by worker bees. There are many studies
conducted on propolis or its active components aiming to find new ...
Systems biology approach for targeted therapy of liver cancer P13K/AKT/MTOR pathway inhibitors : an ally or rival for sorafenib'e
(Bilkent University, 2014)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancerrelated
mortality worldwide. It is the second most frequent cause of cancer death in
men, and the sixth in women due to its aggressive behavior and ...
The role of FLT3 in hepatocellular carcinogenesis
(Bilkent University, 2010)
Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types and it
has a high mortality rate. Its high incidence is a consequence of lack of
biomarkers that could track the progression of the disease. ...
Development of methods for identification and characterization of autologous antibody responses in Small Cell Lung Cancer and Behcet’s Disease
(Bilkent University, 2016-08)
Autologous antibodies are known to be elicited in Behçet’s Disease (BD) and Small Cell Lung Cancer (SCLC). SCLC consists 15-20% of all lung cancer cases. It is follows a most aggressive course and generally patients are ...