Now showing items 1-6 of 6
Identification and characterization of two endoplasmic reticulum protein isoforms encoded by senescence-associated FAM134B gene
(Bilkent University, 2008)
Liver cancer is the fifth most common cancer in the world. Until recently, tumor cells were known to have the capacity to proliferate indefinitely. In a previous study, we showed the spontaneous induction of replicative ...
Molecular analysis of senescence-associated protein phosphatases DUSP10 and MTMR11
(Bilkent University, 2009)
Liver cancer is the fifth most common cancer in the world. Until recently, tumor cells were thought to proliferate indefinitely. In a previous study, our group showed spontaneous induction of replicative senescence in ...
Identification of the role of p33ING1 protein in the cellular activities of p53 tumor suppressor protein
(Bilkent University, 1999)
p53 is a tumor suppressor gene which is mutated in about 50% of human cancers. The product of p53 gene encodes a sequence-specific transcription factor. The genes are transactivated by p53 code for proteins that are ...
Identification of the interacting domain of p53 family members with P33ING1 protein
(Bilkent University, 2002)
p53 is a tumor suppressor gene, which is mutated, in about 50% of human cancers. The product of p53 gene encodes a sequence specific transcription factor. The genes transactivated by p53 code for proteins that are ...
The role of Protein Kinase R in lipotoxicity
(Bilkent University, 2013)
Endoplasmic reticulum (ER) is a central organelle for cellular homeostasis through its myriad of functions including protein and lipid biosynthesis, protein folding and secretion and calcium homeostasis. When protein ...
Characterization of FAM134B in the context of hepatocellular carcinoma and endoplasmic reticulum protein stress
(Bilkent University, 2011)
Family with sequence similarity 134, member B (FAM134B) is a replicative senescence associated gene, previously identified in studies of our group as a result of microarray analysis in spontaneously senescent clones of ...