Search
Now showing items 1-10 of 15
Investigation of resistance mechanisms in response to PIK3CA inhibition in breast cancer
(Bilkent University, 2020-12)
Breast cancer is the most frequently diagnosed cancer type, accounting for 25% of
total cancer cases. PI3K pathway is the most deregulated pathway in breast cancer.
Therefore, many inhibitors have been developed for ...
Analysis of the ATAD2 gene effect on the genes involved in epithelial mesenchymal transition in estrogen positive and negative breast cancers
(Bilkent University, 2021-02)
ATAD2 is overexpressed in many distinct cancer types including breast cancer. Its elevated expression is an indicator of poor prognosis. High ATAD2 expression correlates with short overall survival, disease-free survival ...
Effects of miR-376 family miRNAs on CHRNA5 depleted MCF7 cell line model and co-culture competition studies
(Bilkent University, 2019-07)
Cholinergic receptor nicotinic alpha 5 (CHRNA5) is a ligand-gated ion channel and one
of the subunits of nicotinic acetylcholine receptors. Role of CHRNA5 in tumorigenesis has
been initially shown in the lung tissue in ...
Transcript variants of CELF2 gene as unique prognostic indicators in breast cancer
(Bilkent University, 2022-08)
Breast cancer (BC) is the most common malignant tumor in women around the world. Aside from finding a cure for this disease, it is also critical to identify prognostic biomarkers that can help clinicians intervene with the ...
Functional effects of ATAD2 gene expression in breast cancer
(Bilkent University, 2016-08)
The ATAD2 gene is a newly investigated gene of which the expression levels are associated with the disease prognosis in many types of cancer and especially breast cancer and that is known to be overexpressed usually through ...
Regulation of mineralocorticoid receptor and its downstream targets by estrogen and aldosterone in breast cancer
(Bilkent University, 2016-11)
Many women suffer from breast cancer worldwide thus accurate diagnosis of this disease has become an important issue for treatment options and improved clinical outcomes. Members of steroid hormone receptors, are a subfamily ...
Characterization of chemosensitivity profiles of breast cancer cell lınes, with and without stem cell like features = Kök-hücre özelliği olan ve olmayan meme kanseri hücre hatlarının ilaç hassasiyet profillerinin tanımlanması
(Bilkent University, 2014)
Breast cancer is the second most common cause of death worldwide from cancer due to
complications with its diagnosis and resistance to therapy. Recent studies have shown that
breast tumors when compared with other solid ...
Identification of long non-coding RNAs overcoming tamoxifen resistance in estrogen receptor alpha positive breast cancer
(Bilkent University, 2017-09)
Most of the breast cancer incidences all over the world fall into Estrogen Receptor alpha
(ERα)-positive breast cancer subtype, which are treated with endocrine therapy. Tamoxifen, a
selective ER modulator drug, is the ...
Analysis of CHRNA5 expression in breast cancer cell lines in response to serum starvation and estrogen treatment
(Bilkent University, 2013)
Breast cancer is a complex disease that can be classified into distinct molecular
subtypes including Basal, Luminal A, Luminal B and HER2 positive.
These molecular subtypes mainly differ in their hormone receptor ...
Functional analysis of Erbin gene in breast cancer drug resistance
(Bilkent University, 2021-02)
Erbin is an ERBB2 interacting protein with roles in many signaling pathways. Breast cancer is one of the types of cancer that is affected by Erbin regulation. However, it is unclear how Erbin regulates the biological ...