Now showing items 1-3 of 3
Investigation of resistance mechanisms in response to PIK3CA inhibition in breast cancer
(Bilkent University, 2020-12)
Breast cancer is the most frequently diagnosed cancer type, accounting for 25% of total cancer cases. PI3K pathway is the most deregulated pathway in breast cancer. Therefore, many inhibitors have been developed for ...
Functional analysis of Erbin gene in breast cancer drug resistance
(Bilkent University, 2021-02)
Erbin is an ERBB2 interacting protein with roles in many signaling pathways. Breast cancer is one of the types of cancer that is affected by Erbin regulation. However, it is unclear how Erbin regulates the biological ...
Identification of long non-coding RNAs overcoming tamoxifen resistance in estrogen receptor alpha positive breast cancer
(Bilkent University, 2017-09)
Most of the breast cancer incidences all over the world fall into Estrogen Receptor alpha (ERα)-positive breast cancer subtype, which are treated with endocrine therapy. Tamoxifen, a selective ER modulator drug, is the ...