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Transcript variants of CELF2 gene as unique prognostic indicators in breast cancer
(Bilkent University, 2022-08)
Breast cancer (BC) is the most common malignant tumor in women around the world. Aside from finding a cure for this disease, it is also critical to identify prognostic biomarkers that can help clinicians intervene with the ...
Analysis of the effect of Erbin on the epithelial to mesenchymal transition related genes in breast cancer
(Bilkent University, 2022-09)
Breast cancer is a heterogeneous disease and has complex mechanisms, which brings the need to come up with different approaches for its various types. Erbin is a member of the LAP family and directly interacts with ErbB2 ...
Development of a shiny application for comparative transcriptomics and differential gene expression analysis
(Bilkent University, 2022-09)
RNA sequencing has proven to be an effective technique for divulging information about the transcriptome in molecular biology research. Compared to microarrays and early methods of cDNA sequencing, high-throughput RNA ...
Effects of depletion of CHRNA5 and/or TP53, and transient and stable overexpression of wildtype or mutant TP53 on expression of DLK1-MEG3 locus in MCF7 cells
(Bilkent University, 2022-09)
The expression of CHRNA5 has a prominent role in lung cancer and nicotine addiction. Besides, depletion of CHRNA5 has been identified as being tumour suppressive in breast cancer. Moreover, CHRNA5 depletion causes increases ...