Now showing items 1-4 of 4
Investigating the role of the mediator complex in estrogen receptor alpha-mediated transcription
(Bilkent University, 2018-07)
Mediator is the most important coregulator in eukaryotic transcription. It conveys the signals received from transcriptional activators on enhancer sequences to transcription machinery on promoter regions. Although Mediator ...
Identification of general transcription Factor-Two-E and mediator complex interactions in the context of pre-initiation complex formation
(Bilkent University, 2018-06)
Transcription is a multistep process which requires the presence of many different proteins and protein complexes. The minimal protein components enabling transcription to happen are identified to execute the event in ...
Revealing the role of Med14 in Pol-II transcription regulation
(Bilkent University, 2017-08)
Transcription of protein coding genes by RNA polymerase II (Pol II) is a multi-step process each of which requires a series of factors including coactivators. 30-subunit (the subunits are organized into discrete modules ...
Reconstitution of RNA Polymerase II subunits and analysis of their interaction with PIC components
(Bilkent University, 2018-08)
Mediator Complex is a global coactivator of RNA Pol II transcription machinery. It transmits the regulatory signals from enhancer to promoter region. In the absence of Mediator Complex, Pol II transcription is defected. ...