Now showing items 1-6 of 6
Identification and characterization of two endoplasmic reticulum protein isoforms encoded by senescence-associated FAM134B gene
(Bilkent University, 2008)
Liver cancer is the fifth most common cancer in the world. Until recently, tumor cells were known to have the capacity to proliferate indefinitely. In a previous study, we showed the spontaneous induction of replicative ...
Identification of the role of p33ING1 protein in the cellular activities of p53 tumor suppressor protein
(Bilkent University, 1999)
p53 is a tumor suppressor gene which is mutated in about 50% of human cancers. The product of p53 gene encodes a sequence-specific transcription factor. The genes are transactivated by p53 code for proteins that are ...
Establishment of an experimental system to study p53 effects in Saccharomyces cerevisiae
(Bilkent University, 1997)
The aim of this vv^ork was to establish an experimental model to study human wild type and mutant p53 protein effects in yeast Saccharomyces cerevisiae cells. Wild type p53 was previously shown to be a DNA damage response ...
In silico analysis of mutant p53(R249S) oncogenicity in hepatocellular carcinoma
(Bilkent University, 2007)
Oncogenic properties of mutant p53 proteins still stand as an ill-known subject, and the mechanism responsible for this phenomenon remains to be uncovered. This thesis aims to uncover the effect of p53 codon R249S ...
Identification of the interacting domain of p53 family members with P33ING1 protein
(Bilkent University, 2002)
p53 is a tumor suppressor gene, which is mutated, in about 50% of human cancers. The product of p53 gene encodes a sequence specific transcription factor. The genes transactivated by p53 code for proteins that are ...
Characterization of FAM134B in the context of hepatocellular carcinoma and endoplasmic reticulum protein stress
(Bilkent University, 2011)
Family with sequence similarity 134, member B (FAM134B) is a replicative senescence associated gene, previously identified in studies of our group as a result of microarray analysis in spontaneously senescent clones of ...