Now showing items 1-6 of 6
Mesenchymal stem cell mechanics on osteoinductive peptide nanofibers
(Bilkent University, 2017-08)
In this thesis, changes in Young's modulus of mesenchymal stem cells (MSCs) were investigated during their osteogenic differentiation on bioactive peptide nanofibers that bear triple glutamic acid sequence (EEE), a ...
Self-assembled peptide nanostructure delivery sytems for oligonucleotide therapy
(Bilkent University, 2014-06)
Oligonucleotides are potent therapeutic agents in the treatment of cancer, metabolic, cardiovascular and various hereditary diseases. Despite their great potential, oligonucleotide-based drugs have failed in clinical and ...
Bioactive peptide nanofibers for tissue regeneration
(Bilkent University, 2016-01)
Defects in the tissues or organs caused by trauma or diseases can have detrimental effects on all aspects of patients’ life quality. During the last three decades, considerable developments have been made in tissue engineering ...
Self-assembled peptide based biomaterials for drug delivery and regenerative medicine
(Bilkent University, 2016-06)
Self-assembly is a nature inspired novel engineering tool to build functional new generation of adaptable and complex biomaterials with variety of chemical and physical properties based on recent discoveries at the ...
Boronic acid conjugated peptide amphiphile systems for controlled drug release
(Bilkent University, 2017-09)
Targeted cancer drug delivery is still under investigation and scientists have been focusing on major differences between healthy and cancer tissue to develop novel effective therapies. The cancer microenvironment has ...
Bioinspired organic-inorganic composite materials
(Bilkent University, 2016-05)
Nature has been an inspiration and information source for scientists over centuries, for developing new materials. A great e ort has been spent in order to understand biological materials. The biomineralization process ...