Now showing items 1-15 of 15

    • Biomineralization with engineered cellular systems 

      Ergül, Elif (Bilkent University, 2019-08)
      Hydroxyapatite (HAP) is the final product of bone biomineralization process and HAP formation is controlled by proteins, enzymes and small molecules secreted to extracellular matrix (ECM). Among these molecules, alkaline ...
    • Developing synthetic biology enabled whole cell biosensors 

      Saraylı, Side Selin Su (Bilkent University, 2017-12)
      Main causative agent for environmental pollution is human activities. Especially with accelerated industrial improvements, many inorganics such as heavy metals or hazardous organic toxic materials are released to the ...
    • Functional bacterial amyloid nanomaterials 

      Önür, Tuğçe (Bilkent University, 2016-11)
      Mis-folded or unfolded proteins tend to aggregate and aggregated structures are called as amyloids. Amyloid formation contributes to some human diseases and resulting in death in some cases. On the other hand, functional ...
    • Genetically programmed engineered cells for biomaterials synthesis 

      Kırpat, Büşra Merve (Bilkent University, 2021-01)
      Several organisms can process nanomaterials and producing in various sizes and morphologies in mild conditions by utilizing specific proteins. In sea sponges, silicatein proteins play a key role in synthesizing silica ...
    • Glycosylation: a tool for engineering protein based materials 

      Işılak, Musa Efe (Bilkent University, 2019-09)
      Biofilms are bacterial communities formed by adhesion of cells to each other via extracellular matrix. Proteins, one of the components of biofilm matrix, can form fibers and have properties enabling their use as materials. ...
    • Microbial amyloids as functional biomaterials 

      Kehribar, Ebru Şahin (Bilkent University, 2021-02)
      Amyloids are fibrillar aggregations of proteins, dominated by β-sheets in the structure. Although amyloids are historically associated with disorders, they emerged as outstanding biomaterials due to their high mechanical ...
    • Multiplexed cell-based diagnostic devices for the detection of kidney disease pathological markers 

      Köse, Sıla (Bilkent University, 2021-01)
      Development of accurate, inexpensive and fast-screening devices has been a big vacancy in the field of medical diagnostics. Close monitoring and diagnosis of various diseases are generally conducted by typical analytical ...
    • Peptide based ligand discovery to prevent protein aggregation in neurodegenerative disease conditions 

      Beğli, Özge (Bilkent University, 2019-09)
      Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease are cognitively and physically debilitating and progressive diseases due to the gradual and irreversible loss of discrete ...
    • Peptide drug candidates for pathogenic amyloids 

      Özçelik, Cemile Elif (Bilkent University, 2020-01)
      Amyloid fibrils are very stable, ordered cross-β structured, resistant to protease degradation, proteinaceous composits. All amyloids have different peptide/protein sequences although they express similar structural ...
    • A self-actuated cellular protein delivery machinery 

      Ahan, Recep Erdem (Bilkent University, 2018-08)
      Owing to increase the knowledge on biology and available tools for genetic manipulations, biological systems are engineered to perform complex tasks. They can be designed to degrade toxic molecules in environment, produce ...
    • A synthetic biology approach for engineered functional biofilm 

      Kalyoncu, Ebuzer (Bilkent University, 2018-01)
      Extracellular polymeric substances consist of molecules, DNAs, carbohydrates, and proteins that are secreted by microbial biofilms. These molecules assist in the synthesis of bacterial biofilms as highly ordered, complex ...
    • A synthetic biology approach for nanomaterial design, synthesis and functionalization 

      Ölmez, Tolga Tarkan (Bilkent University, 2017-11)
      Biological formation of inorganic material occurs in most organisms in nature. Various biomolecules such as polypeptides, lipids and metabolites are responsible for biomineralization in cells and tissues. Biological synthesis ...
    • Synthetic cellular systems for whole cell biocatalysis 

      Apaydın, Onur (Bilkent University, 2017-10)
      Synthetic biology is a field utilizing basic science and engineering approaches to create novel synthetic systems. Biocatalysis is one of those already existing processes which was reviewed intensely due to its advantages ...
    • Synthetic genetic circuits to monitor nanomaterial triggered toxicity 

      Saltepe, Behide (Bilkent University, 2020-08)
      In the past decades, nanomaterial (NM) usage in various fields has been of great interest because of their unique properties that show tuneable optical and physical properties depending on their size. Yet, safety ...
    • A theranostic bio-device for biomedical applications 

      Hacıosmanoğlu, Nedim (Bilkent University, 2019-08)
      Biological systems are programmable by their nature. With using the abilities of these systems, scientists have designed, engineered and repurposed living machines for various tasks including biological sensing, recording ...