Theses - Graduate Program in Neuroscience
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Peptide therapeutics to prevent protein aggregation in Huntington’s disease
(Bilkent University, 2022-09)Huntington’s disease is a progressive, autosomal dominant neurodegenerative disease caused by dramatic CAG repeat expansion in exon 1 of the Huntington (HTT) gene. More than 36 CAG repeats lead to the generation of mutant ... -
Cortical processes underlying attentional modulations of dynamic vision
(Bilkent University, 2022-09)Visual attention is one of the most fundamental cognitive functions guiding and influencing a various number of processes. However, how different neural mechanisms are modulated by selective attention to process information ... -
Neural underpinnings of biological motion perception under attentional load
(Bilkent University, 2022-06)Humans can detect and differentiate biological motion from non-biological motion stimuli effortlessly, even if the stimuli were shown as simplistic as a composition of moving dots (i.e. point-light displays [PLD]). Considering ... -
Effects of recreational cannabis use and subclinical psychosis risk on brain white matter integrity and structural connectivity in adolescence
(Bilkent University, 2022-06)The impact of cannabis use on the psychosis risk in the healthy population has been less examined in the literature. Furthermore, previous diffusion tensor imag-ing and structural connectivity studies investigating the ... -
Explicit and implicit measurement of mind perception in social robots through individual differences modulation
(Bilkent University, 2022-06)The attribution of mental states to the object or subject that an individual interacts with according to its appearance or behavior is called mind perception (Gray et al., 2007). Recent research on human-robot interaction ... -
Modulation of the neuroinflammatory response following genetic and environmental manipulations in the zebrafish (Danio Rerio)
(Bilkent University, 2022-05)Aging is an inevitable process through which organisms experience functional and physical decline. Cellular changes such as mitochondrial dysfunction, telomere attrition, and loss of proteostasis constitute the main ... -
Structural connectivity alters in pediatric systemic lupus erythematosus prior to neuropsychiatric manifestations
(Bilkent University, 2022-02)Systemic lupus erythematosus (SLE) is an autoimmune multi-system disorder affecting the central nervous system which may exhibit neuropsychiatric manifestations. Pediatric-onset SLE is rare and although there is an ... -
Transcriptomic alterations in the aged brain with and without dietary and dietary- mimetic manipulations
(Bilkent University, 2021-12)Aside from many genetic and environmental influences on the brain, aging itself is a significant risk factor for accelerated cognitive decline, making aging research crucial due to the increasing population age in our era. ... -
Spatially informed voxelwise modeling and dynamic scene category representation in the human brain
(Bilkent University, 2021-12)Humans have an impressive ability to rapidly process global information in natural scenes to infer their category. Yet, it remains unclear whether and how scene categories observed dynamically in the natural world are ... -
Identification of modulatory functions of TP53, estrogen signaling, and 14q32.31 miRNA cluster on CHRNA5 knock-down expression profile and development of syneRgy APP
(Bilkent University, 2021-09)Cholinergic receptor subunit alpha 5 (CHRNA5) is a ligand-gated ion channel expressed in not only the nervous system but also other tissues. Differential expression and the polymorphisms of CHRNA5 have been associated with ... -
Natural speech representations in the human brain during a cocktail party
(Bilkent University, 2021-08)Humans are remarkably adept in selectively listening to a desired speaker in a crowded environment, while filtering out non-target speakers in the background. Attention is key to solving this difficult cocktail-party task, ... -
Neurophysiological investigation of contrast ratio effects on metacontrast masking
(Bilkent University, 2021-08)Visual masking has been used as an investigative tool to understand the dynam-ics of sensory and perceptual processing. Given that masking can also cause aware and unaware visual conditions, it has also found applications ... -
Investigating motion detection of aging zebrafish with optomotor response
(Bilkent University, 2021-07)Various aspects of visual functioning including motion perception have been shown to be significantly altered throughout aging. Contrary to the traditional view focusing on structural changes in the eye and retina, ... -
Characterizing surround suppression in motion direction perception
(Bilkent University, 2021-06)Visual perception is often achieved by surround modulation mechanisms, which help us pool individual information in our visual field. This mechanism is also prominent in motion perception, namely motion discrimination. A ... -
Genetic and environmental interventions altering the course of brain aging: evidence from the zebrafish (Danio Rerio) model
(Bilkent University, 2021-04)Age-related cognitive decline occurs during normal aging, although there is no prominent neural loss in the brain. Subtle molecular alterations in synaptic and cellular dynamics are likely underlying these cognitive ... -
Behavioral and computational investigation of the effect of prior knowledge on visual perception
(Bilkent University, 2021-01)Visual perception results from the dynamic interaction of bottom-up and topdown processes. Top-down prior knowledge and expectations can guide us to predict upcoming events and even determine what we see in an ambiguous ... -
Effects of aging on gene expression levels of inflammatory, cytoskeletal and microglial markers in the brain using the zebrafish (Danio Rerio) model organism
(Bilkent University, 2021-01)Age-related cognitive decline burdens the elderly population, limiting their abil-ity to socialize and be independent. To be able to develop proper treatments, healthy aging should be examined. Previous studies focusing ... -
Mineralocorticoid and glucocorticoid receptors as novel targets in breast and liver cancer therapies
(Bilkent University, 2020-12)Cell signaling is a complex phenomenon and is maintained through intertwined signal transmissions within and in-between the cells. Anti-cancer therapies are often challenged by this fact due to crosstalk-associated ... -
Spatial attention and paracontrast masking
(Bilkent University, 2021-01)Visual masking is a powerful methodological tool to investigate the dynamics of sensory processing associated with object visibility and identity. Previous paracontrast masking studies revealed three distinct components ... -
Investigating the effects of perceptual learning on the function and microstructure of the visual cortex
(Bilkent University, 2020-12)Perceptual learning is the long-term improvement of the ability to process sensory stimuli through experience. Although an extensively studied field, the mechanism and locus of plasticity underlying visual perceptual ...
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