Theses - Graduate Program in Neuroscience
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Analysis of movement disorder-related genes following knockdowns of ANO10, WDR81, and VLDLR in zebrafish (DANIO RERIO)
(Bilkent University, 2018-07)Movement Disorders are the neurological symptoms that cause alterations in normal motility, posture and muscle tone. Certain brain areas, such as the cerebellum, mediate correct motor control and functioning. When defects ... -
Genetic influences on cortical structure and function
(Bilkent University, 2018-07)Structure and function of the human central nervous system is determined by both genetic and environmental in uences. One of the fundamental quests in neuroscience studies is to determine to what degree each of these ... -
The effect of context-dependent lightness on contrast detection and identification, and its neural correlates
(Bilkent University, 2017-11)Perceived contrast of a grating varies with its background (or mean) luminance: of the two gratings with the same photometric contrast the one on higher luminance background appears to have higher contrast. On the other ... -
Haptic and visual dimensions of perceived softness
(Bilkent University, 2017-10)Exploring the environment with our senses is a prerequisite to successfully and efficiently interact with it. Our senses provide information about what material objects and surfaces are made of and help us to stay clear ... -
Development of bioactive peptide nanofibers for intervertebral disc regeneration
(Bilkent University, 2017-08)Lower back pain (LBP) and neck problems are the most common orthopedic diseases worldwide, and the main reason behind LBP is intervertebral disc degeneration (IVDD). Therefore, specialized therapeutic applications to induce ... -
Investigation of spontaneous differentiation of neural stem cells on synthetic scaffolds
(Bilkent University, 2017-08)Despite the increasing incidents of brain injuries and neurodegenerative diseases, a definitive clinical therapy for these conditions has not been found yet. Nervous system injuries result in loss of neural cells, causing ... -
Identification and characterization of exonic variants related with familial essential tremor
(Bilkent University, 2017-07)Essential tremor (ET) is the most common movement disorder in humans. Despite its high heritability and frequency, the genetic basis and pathophysiology of ET is not well understood. In this study, whole exome sequencing ... -
Investigating the effects of bioactive peptide nanofibers on the growth and differentiation behaviour of nervous system cells
(Bilkent University, 2017-08)Peripheral nerve regeneration is a tightly regulated process that entails the degeneration, proliferation, alignment and remyelination of Schwann cells. Tuning the bioactivity is important to support all of these processes ... -
Age and gender alter synaptic proteins in zebrafish (Danio Rerio) models of normal and delayed aging
(Bilkent University, 2017-07)Cognitive decline occurs during normal aging in some specific domains of cognitive abilities including but not limited to episodic memory, divided attention and executive functions, however, it is not a unitary decline ... -
Eliciting immune response by using nanostructures
(Bilkent University, 2017-07)The ability of dendritic cells to coordinate innate and adaptive immune responses makes them essential targets for vaccination strategies. Presentation of specific antigens by dendritic cells is required for the activation ... -
Alterations in the molecular properties of neural stem cells from aged brains and brain tumors
(Bilkent University, 2017-07)It is known that new neuron formation in the brain continues throughout the life of an organism. In the adult human brain, it was proven that neurogenesis in the hippocampus is higher than expected, almost 700 new neurons ... -
Behavioral display of lumbar curvature in response to the opposite sex
(Bilkent University, 2017-06)The aim of this thesis was to investigate the hypothesis that women adjust their lumbar curvature to approach the suggested biomechanical optimum of 45.5 degrees in response to the presence of an attractive member of the ... -
The effect of task on cue usefulness for visual scene classification
(Bilkent University, 2017-06)Detecting objects in the environment is one of the most fundamental functions of the visual system. Humans are highly effective at this, and past studies have shown that we can process things like whether or not an animal ... -
A self assembled nanofibrous structure as a novel vaccine adjuvant
(Bilkent University, 2017-02)Vaccination is the most effective and cost-efficient way of protection against the major infectious diseases but ideal vaccine formulation has not been found. Recent vaccine systems are mainly composed of two major substitutes ... -
Expression of key synaptic proteins in Zebrafish (Danio Rerio) brain following caloric restriction and its mimetic and their relationship with gender
(Bilkent University, 2017-01)Aging is a progressive decline of physiological functioning and metabolic processes. Among all the organs, the brain seems to be the most vulnerable part of the body to the age-related changes because of the relatively ... -
Audiovisual interactions in time and spatial grouping principles of vision
(Bilkent University, 2016-11)Multisensory integration is often studied with intermodal con ict where either visual input dominates and alters the percept of simultaneous auditory input or the other way around. For instance, when put in con ict, visual ... -
Design and application of nerve growth factor-β binding peptide nanofibers for neural regeneration
(Bilkent University, 2016-11)Promotion of neurite outgrowth is an important limiting step for the regeneration of nerve injury and depends strongly on the local expression of nerve growth factor (NGF). Rational design of bioactive materials is a ... -
Effects of aging and short-term dietary restriction on neurogenesis and cellular senescence in the zebrafish (Danio Reio) brain
(Bilkent University, 2016-09)Currently we know from rodent and fish studies that adult neuron generation is reduced but still continues in old animals with a dynamic change throughout aging. This process occurs mainly in hippocampal region, which is ... -
Identification of candidate genes for familial essential tremor
(Bilkent University, 2016-09)Essential tremor (ET) is one of the most common movement disorders in humans and is characterized by action tremors that occur during voluntary motion. However, due to the strong heterogeneity exhibited by ET patients at ... -
Changes in FMRI resting state networks due to audiovisual association induced effects on visual motion perception
(Bilkent University, 2016-08)Associative learning, the process by which an association between two stimuli or a behavior and a stimulus is learned, is one of today's exciting and important topics of neuroscience. The in uence of multisensory ...
