Theses - Graduate Program in Neuroscience
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Effects of varying levels and differing durations of calorie restriction on cellular and synaptic proteins, as well as the inflammatory state of the female mouse brain
(Bilkent University, 2020-10)Aging is an inevitable and complicated process leading to functional decline. Regarding brain aging, cognitive decline takes place in multiple domains, including learning, memory, executive functions, motor coordination, ... -
Identification of preclinical implications for novel indole-benzimidazoles and phenothiazines using in vitro cancer cell line and in vivo zebrafish models
(Bilkent University, 2020-09)Breast cancer (BC) and hepatocellular carcinoma (HCC) are two major health problems with significant mortality rates. Although drug therapies are available, therapeutic success remains limited. Because of low bioavailability, ... -
Effects of aging, diet and potential genetic interventions on the levels of Smurf2 and its interacting partners in Zebrafish (Danio Rerio) brain
(Bilkent University, 2020-10)Aging is a natural process that is ultimate combination of numerous intrinsic and extrinsic changes in an organism. Contrary the common belief, brain aging is not a loss of neurons while it has been shown that subtle ... -
Probing sensory plasticity with rapid forms of motion adaptation
(Bilkent University, 2020-09)Perception is shaped by both immediate pattern of sensory inputs and previous experience with the external environment. Visual adaptation, a temporary change in perception following exposure to a stimulus, has been widely ... -
Age-dependent effects of short-term intermittent fasting and rapamycin treatment in Zebrafish (Danio Rerio) brain
(Bilkent University, 2020-05)World populations are rapidly aging, and there is an urgent need to develop interventions that prevent or reverse age-related deterioration of health. To date, several approaches have been developed to extend health span. ... -
Functional changes in the human cortex over the course of visual perceptual learning
(Bilkent University, 2020-04)In this study we assessed functional changes through visual perceptual learning with bisection discrimination task. Before learning, after third session of learning and after learning ended, behavioral threshold and fMRI ... -
Investigating the mechanisms of telomere maintenance in zebrafish tissues and human brain cancer cell lines
(Bilkent University, 2019-09)Telomeres are nucleoprotein complexes formed at each end of the chromosomes to protect these ends from deterioration. In each round of cellular division, telomeric sequences shorten due to the end replication problem of ... -
Age related alterations of adult neurogenesis and astrocytes in Zebrafish (Danio Rerio)
(Bilkent University, 2019-09)Brain aging is marked by a decline in cognitive abilities and associated with neurodegenerative disorders. In order to identify appropriate interventions to change the course of brain aging and age-related neurological ... -
Comparing the performance of humans and 3D-convolutional neural networks in material perception using dynamic cues
(Bilkent University, 2019-08)There are numerous studies on material perception in humans. Similarly, there are various deep neural network models that are trained to perform different visual tasks such as object recognition. However, the intersection ... -
Effect of visual stimuli with fearful emotional cue on population receptive field estimates
(Bilkent University, 2019-07)Previous studies showed that the content of stimulus might affect the results of population receptive field (pRF) estimation method [1, 2, 3]. In addition, emotion might modulate visual processing in humans by increasing ... -
Temporal and spatial nonlinearities in FMRI BOLD response in human primary visual cortex
(Bilkent University, 2019-08)It is generally assumed that fMRI BOLD response (i.e., functional magnetic resonance imaging blood-oxygen-level-dependent signal) is linear and time-invariant. In this study, we investigated spatial and temporal ... -
Mapping human visual cortex with population receptive field model: tuning FMRI and stimulus parameters, and exploring receptive field sizes
(Bilkent University, 2019-07)Human visual cortex has been studied extensively since blood oxygen-level dependent (BOLD) signal was discovered by magnetic resonance imaging (MRI) researchers in 1990's [1]. It was not long after that, the researchers ... -
Task difficulty and expertise mediate the effects of roving on perceptual performance
(Bilkent University, 2019-02)Experience-dependent improvement of perception, known as perceptual learning, is possible in the absence of feedback, but feedback enables faster progress as demonstrated by both unsupervised and supervised learning ... -
EEG correlates of audiovisual associations in motion perception
(Bilkent University, 2018-12)The process of associative learning has been considered to be one of the promising research areas in neuroscience to understand human perception, sensory plasticity, and multisensory integration that affects the way of ... -
Reciprocal influences of interpretation and attentional biases to health-related information
(Bilkent University, 2018-10)Cognitive processing biases to health-related information have been endorsed to be present in patients who are su ering from medical diseases. Attentional bias is one of the cognitive processes which facilitates the ... -
The role of contrast and size in motion perception: behavioral and neuroimaging study of center-surround interactions in primary visual cortex (V1) and middle temporal area (MT+)
(Bilkent University, 2018-10)Behavioral experiments have demonstrated that observers' ability to discriminate the drift direction of a grating improves as its size increases if the grating has a low contrast, and deteriorates if it has a high contrast ... -
Co-expression pairs and modules (CoEX-PM): a shiny application and an example case study on chromogranins
(Bilkent University, 2018-09)Gene expression signatures have been proved to be effective biomarkers of tumorigenesis and metastasis especially when alternative methods are inconvenient or ineffective. Nevertheless, handling very large datasets obtained ... -
Arithmetic and temporal transformations of working memory activation in subjects prone to psychosis
(Bilkent University, 2018-09)Working memory (WM) deficit is a well-studied cognitive impairment in psychosis which is stemming from various developmental abnormalities containing neurobiological heterogeneity. Recently, many studies have concluded ... -
Analysis of movement disorder-related genes following knockdowns of ANO10, WDR81, and VLDLR in zebrafish (DANIO RERIO)
(Bilkent University, 2018-07)Movement Disorders are the neurological symptoms that cause alterations in normal motility, posture and muscle tone. Certain brain areas, such as the cerebellum, mediate correct motor control and functioning. When defects ... -
Genetic influences on cortical structure and function
(Bilkent University, 2018-07)Structure and function of the human central nervous system is determined by both genetic and environmental in uences. One of the fundamental quests in neuroscience studies is to determine to what degree each of these ...
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