Browsing Theses - Department of Molecular Biology and Genetics by Title
Now showing items 217-224 of 224
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Unfolded protein response regulated mirnas in lipotoxic endoplasmic reticulum stress in macrophages
(Bilkent University, 2014-07)The proper functioning and the development of the cell is essential to the fitness of the multicellular organisms - any significant disturbances in cellular mechanisms can lead to a multitude of diseases or death. Among ... -
Unmasking of epigenetically silenced genes and identification of transgelin as a potential methylation biomarker in breast cancer
(Bilkent University, 2015-11)Tumor suppressor genes (TSG) are frequently silenced in cancer by epigenetic mechanisms, including promoter DNA hypermethylation and repressive chromatin formation by means of histone deacetylation. 5-aza-2'-deoxycytidine ... -
The use of nanoparticle labeling in cellular tracking
(Bilkent University, 2015-09)Adult stem cells (ASCs) are a population of multipotent cells which have ability of self-renewal and tissue regeneration. Due to their protective and restorative roles, ASCs become candidate for cellular therapies. Some ... -
Validation of prognostic biomarkers for overall survival in melanoma patients undergoing autologous vaccination
(Bilkent University, 2014)Malignant Melanoma is deadliest type of skin cancer, seen with low frequency. Lack of diagnostic and prognostic markers are important obstacles during early detection and selection of appropriate adjuvant therapy for ... -
WNT/(formula)-Catenin signaling pathway activation in epithelial cancers
(Bilkent University, 2006)Wnt signaling is involved in a large set of cellular and developmental processes, and when mis-regulated can lead to both degenerative diseases and many types of cancer. The involvement of Wnt signaling was already well ... -
X chromosome inactivation in female predisposition to autoimmunity
(Bilkent University, 2008)The high female preponderance is thought to be important in identifying the etiological factors. Sex hormones, pregnancy related microchimerism, and environmental factors are investigated as likely candidates. Disturbed ... -
Zebrafish as a model for analysis of signaling pathways involved in cell growth, proliferation and development
(Bilkent University, 2011)Zebrafish is an emerging and promising model organism to study cancer formation, organogenesis, development, cell signaling, and drug screening applications. Cellular signaling driven by E2F and TOR proteins regulate ... -
Zebrafish as an in vivo model of drug screens for liver cancer: the role of phenothiazines
(Bilkent University, 2021-08)Hepatocellular carcinoma (HCC) is one of the most dangerous cancer types and sorafenib (SFB) is a commonly used drug against HCC, being the only FDA-approved medication until 2018. However, its limited efficacy and severe ...
