Browsing Theses - Department of Molecular Biology and Genetics by Title
Now showing items 203-222 of 224
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Senescence and immortality genes as markers of hepatocellular carcinogenesis
(Bilkent University, 2009)Cellular senescence is a tumor-suppression mechanism, and immortalization facilitates neoplastic transformation. Both mechanisms may be highly relevant to hepatocellular carcinoma (HCC) development. We worked on two major ... -
Skewed x-chromosome inactivation in juvenile idiopathic arthritis and rheumatoid arthritis
(Bilkent University, 2012)There is a female predominance in most of the autoimmune diseases, and it is thought to play an important role in identifying the etiological factors. Sex hormones, microchimerism and environmental factors are thought ... -
Smoking and nicotine alter UGT1A expression
(Bilkent University, 2011)The expression and activity of enzymes taking role in drug metabolism are important as in the case of phase II glucuronidation enzymes; namely UDPglucuronosyltransferases (UGTs). Previously, it has been identified that ... -
An SSX4 knock-in cell line model and in silico analysis of gene expression data as two approaches for investigating mechanisms of cancer
(Bilkent University, 2009)Cancer/testis (CT) genes mapping to the X chromosome (CT-X) are normally expressed in male germ cells but not in adult somatic tissues, with rare exception of oogonia and trophoblast cells; whereas they are aberrantly ... -
Stem cell-like protein expression in breast cancer cell lines
(Bilkent University, 2003)Breast cancer is the most common type of cancer and the second leading cause of cancer deaths among women. Most of breast carcinoma arises from the breast ductal epithelium. Recent studies in the past decade have displayed ... -
Studies on estradiol dependent transcriptional regulation of human Sodium Iodide Symporter gene in mammary glands
(Bilkent University, 2002)Sodium Iodide Symporter (NIS) is a transmembrane protein, which is expressed in thyroid, mammary gland (mg), stomach, and salivary gland. NIS’s transcriptional regulation in terms of cis-and trans-acting elements in ... -
Suppressive oligodeoxynucleotides as a TLR antagonist : efforts to treat autoimmune diseases
(Bilkent University, 2007)Synthetic oligodeoxynucleotides (ODN) expressing suppressive TTAGGG motifs effectively down-regulate the production of proinflammatory and Th1 cytokines elicited by a variety of Toll-Like Receptor (TLR) dependent or ... -
Systems biology approach for targeted therapy of liver cancer P13K/AKT/MTOR pathway inhibitors : an ally or rival for sorafenib'e
(Bilkent University, 2014)Hepatocellular carcinoma (HCC) is one of the leading causes of cancerrelated mortality worldwide. It is the second most frequent cause of cancer death in men, and the sixth in women due to its aggressive behavior and ... -
Targeting adenosine receptors to improve vaccine efficacy
(Bilkent University, 2016-12)Vaccination is the major protection method against many diseases caused by pathogens through creating acquired immunity. Vaccines can be classified in two major groups, which are subunit vaccines and attenuated vaccines. ... -
Therapeutic approaches to the prevention of liver fibrosis and cancer progression
(Bilkent University, 2015-08)In our previous studies on liver regeneration, we demonstrated that following partial hepatectomy (PH) FLT3 contributes cellular proliferation that provides a basis for liver regeneration. Moreover, we were able to suggest ... -
Therapeutic potential of an immunosuppressive oligodeoxynucleotide encapsulated within liposomes on bleomycin-induced mouse model of lung inflammation and fibrosis
(Bilkent University, 2019-05)Systemic sclerosis (SSc) is an autoimmune/autoinflammatory disease with unknown etiology. It is characterized by vascular dysfunction, inflammation and disseminated fibrosis of skin or internal organs. Although its prevalence ... -
Tissue specific transcriptome of zebrafish in ache mutant embryos
(Bilkent University, 2019-06)Differential expression of specific genes in certain tissues provides information about tissue specificity which might define phenotypes of various tissues. It is possible to understand the tissue-specific effects of ... -
TLR agonists on autoimmunity, cancer and M1/M2 macrophage polarization
(Bilkent University, 2019-07)Macrophages play an important role in the initiation of immune responses and the maintenance of immune homeostasis. Alterations in their phenotype, function and activation state have been implicated in the pathogenesis ... -
Tumor suppressor functions of p53 gene
(Bilkent University, 2000) -
Unfolded protein response regulated mirnas in lipotoxic endoplasmic reticulum stress in macrophages
(Bilkent University, 2014-07)The proper functioning and the development of the cell is essential to the fitness of the multicellular organisms - any significant disturbances in cellular mechanisms can lead to a multitude of diseases or death. Among ... -
Unmasking of epigenetically silenced genes and identification of transgelin as a potential methylation biomarker in breast cancer
(Bilkent University, 2015-11)Tumor suppressor genes (TSG) are frequently silenced in cancer by epigenetic mechanisms, including promoter DNA hypermethylation and repressive chromatin formation by means of histone deacetylation. 5-aza-2'-deoxycytidine ... -
The use of nanoparticle labeling in cellular tracking
(Bilkent University, 2015-09)Adult stem cells (ASCs) are a population of multipotent cells which have ability of self-renewal and tissue regeneration. Due to their protective and restorative roles, ASCs become candidate for cellular therapies. Some ... -
Validation of prognostic biomarkers for overall survival in melanoma patients undergoing autologous vaccination
(Bilkent University, 2014)Malignant Melanoma is deadliest type of skin cancer, seen with low frequency. Lack of diagnostic and prognostic markers are important obstacles during early detection and selection of appropriate adjuvant therapy for ... -
WNT/(formula)-Catenin signaling pathway activation in epithelial cancers
(Bilkent University, 2006)Wnt signaling is involved in a large set of cellular and developmental processes, and when mis-regulated can lead to both degenerative diseases and many types of cancer. The involvement of Wnt signaling was already well ... -
X chromosome inactivation in female predisposition to autoimmunity
(Bilkent University, 2008)The high female preponderance is thought to be important in identifying the etiological factors. Sex hormones, pregnancy related microchimerism, and environmental factors are investigated as likely candidates. Disturbed ...
