Browsing Theses - Department of Molecular Biology and Genetics by Title
Now showing items 180-199 of 224
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qPCR validation of in vivo diagnostic importance and regulation by estrogen for CHRNA5 isoform expression in breast cancer
(Bilkent University, 2014)Breast cancer has multiple molecular subtypes; normal-like, basal-like, luminal A, luminal B and HER2 positive depending on receptor status of tumor cells. Cancer therapy is tailored according to the type of cancer; hence ... -
Quadrupedal gait in humans : identification and partial characterization of a novel gene WD repeat domain 81 (WDR81)
(Bilkent University, 2011)Identi cation of disease genes responsible for cerebellar phenotypes provides mechanistic insights into the development of cerebellum. Neural pathways involved in bipedal gait in humans is not completely understood. ... -
Reactivation of telomerase reverse transcriptase gene in liver cancer
(Bilkent University, 2014-09)Hepatocellular Carcinoma (HCC) is one of the major causes of cancer related deaths worldwide and its incidence has been increasing drastically, especially in western countries. HCC has a heterogeneous molecular and ... -
Reconstitution of RNA Polymerase II subunits and analysis of their interaction with PIC components
(Bilkent University, 2018-08)Mediator Complex is a global coactivator of RNA Pol II transcription machinery. It transmits the regulatory signals from enhancer to promoter region. In the absence of Mediator Complex, Pol II transcription is defected. ... -
Reconstitution of the partial tail module of the human mediator complex
(Bilkent University, 2021-09)RNA Polymerase II (Pol II) regulates and maintains every aspect of the cell through the act of transcription of protein coding genes. Transcription of protein coding genes depends on extrinsic and intrinsic signals to the ... -
Regulation of human monocyte differentiation into m1- and m2-like macrophages
(Bilkent University, 2016-05)Myeloid-derived suppressor cells (MDSC) play a key role in down-regulating activated T and NK cells. MDSC are emerging as targets for cancer immunotherapy since they protect tumor cells from immune elimination. We ... -
Regulation of mineralocorticoid receptor and its downstream targets by estrogen and aldosterone in breast cancer
(Bilkent University, 2016-11)Many women suffer from breast cancer worldwide thus accurate diagnosis of this disease has become an important issue for treatment options and improved clinical outcomes. Members of steroid hormone receptors, are a subfamily ... -
Revealing the role of Med14 in Pol-II transcription regulation
(Bilkent University, 2017-08)Transcription of protein coding genes by RNA polymerase II (Pol II) is a multi-step process each of which requires a series of factors including coactivators. 30-subunit (the subunits are organized into discrete modules ... -
RNA based biomarkers for prediction of the endometrial window of implantation
(Bilkent University, 2020-12)Early reproductive failure is the most common issue related to successful pregnancies, as around 30% of all conceptions reach live birth. The path to a successful pregnancy is reliant on the successful implantation of the ... -
RNASEL G1385A variant and breast cancer susceptibility
(Bilkent University, 2003)RNASEL (MIM# 180435) encodes for the ubiquitously expressed ribonuclease L (RNase L), which mediates the antiviral and pro-apoptotic activities of the 2-5A system. Recently, RNASEL Arg462Gln (G1385A) variant is shown to ... -
Role of dietary ethiological factors in the molecular pathogenesis of liver cancer
(Bilkent University, 2011)Hepatocellular carcinoma is ranked third foremost cause of cancer deaths. Dietary factors play a crucial role in the molecular pathogenesis of liver cancer. Oxidative stress is usually coupled with the malignancy and ... -
Role of environmental factors in mesenchymal stem cell biology
(Bilkent University, 2009)Mesenchymal Stem Cells (MSCs) have the abilities of self-renewal and differentiation into fat, bone, cartilage, and muscle tissues. Besides intrinsic mechanisms that control the fate of the MSCs, extrinsic physiological ... -
Role of estrogen on the maintenance and homing capacity of bone marrow derived rat mesenchymal stem cells
(Bilkent University, 2011)Mesenchymal Stem Cells (MSCs) can self renew and differentiate into different cell types like, adipocytes, osteoblasts, chondrocytes, neurons, hepatocytes and endothelial cells. Their ability to differentiate into wide ... -
Role of FAM134B in liver cancer
(Bilkent University, 2013)The family with sequence similarity 134, member B (FAM134B) protein initially caught attention in our laboratory through demonstrating elevated levels possibly associated with senescent, cirrhotic, and mesenchymal-like ... -
The role of FLT3 in hepatocellular carcinogenesis
(Bilkent University, 2010)Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types and it has a high mortality rate. Its high incidence is a consequence of lack of biomarkers that could track the progression of the disease. ... -
Role of histone variant H3.3 in transcription and mitotic progression
(Bilkent University, 2017-04)Chromatin structure needs to be dynamic and flexible in order for the eukaryotic cellular processes to function correctly. Incorporation of histone variants into chromatin serves to increase epigenetic plasticity by ... -
The role of IRE1 in metaflammation and atherosclerosis
(Bilkent University, 2017-05)Chronic metabolic overloading of anabolic and catabolic organelles such as the endoplasmic reticulum (ER) and mitochondria is a major cause of inflammation in obesity. ER serves as a critical metabolic center for protein, ... -
Role of JMJD5 in liver cancer
(Bilkent University, 2013)Being one of the most common cancer types in human population, hepatocellular carcinoma (HCC) has high rate of deaths due to the challenges in its diagnosis and treatment. In recent years, epigenetic regulators have come ... -
The role of lipid-induced integrated stress response in metaflammation and atherosclerosis
(Bilkent University, 2019-07)Chronic inflammation resulting from metabolic overloading of organelles (such as the endoplasmic reticulum (ER) and mitochondria that control cellular homeostasis) is a major cause of metabolic disorders including diabetes, ... -
The role of mediator complex in tamoxifen resistance of ER-positive breast cancer
(Bilkent University, 2022-01)Breast cancer is the most prevalent cancer type and the leading cause of cancer mortality among women worldwide. Estrogen receptor-positive (ER+) breast cancer is the most common clinical subtype with an incidence rate ...
