Browsing Theses - Department of Molecular Biology and Genetics by Title
Now showing items 168-187 of 224
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p53 mutations as a source of aberrant Beta-catenin accumulation in cancer cells
(Bilkent University, 2002)β-catenin is involved in both cell-cell interactions and wnt pathway-dependent cell fate determination through its interactions with E-cadherin and TCF/LEF transcription factors, respectively. Cytoplasmic/nuclear levels ... -
Platelet-derived microparticles differentially regulate macrophage polarization
(Bilkent University, 2016-09)Platelet-derived microparticles (PMPs) shed from platelets upon activation and constitute almost 90% of the circulating microparticles. Due to their versatile cargo, PMPs were associated with the generation of immunosuppressive ... -
POLR2A/RPB1 subunit of RNA polymerase II interacts with NTDMED14 containing core mediator complex to facilitate basal and activator driven transcription
(Bilkent University, 2020-06)The Metazoan Mediator is a 2-MDa protein complex that consist of 30 subunits, most of which are evolutionarily conserved from yeast to humans8. The maintenance and regulation of the cell is dependent on spatiotemporal ... -
Polymorphisms in P21 (CODON 31) and P53 (CODON 72) : association with breast cancer susceptibility in the Turkish and Greek populations
(Bilkent University, 2003)The aim of this study was to investigate the potential association of p53 codon 72 and/or p21 codon 31 polymorphisms with increased susceptibility for breast cancer either independently or combined in the Turkish and ... -
Polymorphisms of Glutathione S- transferase genes (GSTM1, GSTP1, and GSTT1) and breast cancer susceptibility in the Turkish population
(Bilkent University, 2002)The potential association between the Glutathione S- transferase genes GSTM1, GSTT1, GSTP1 and breast cancer susceptibility was investigated in a case control study of 264 female patients and 233 age-matched controls in ... -
Prediction of prognosis and chemosensitivity in breast cancer
(Bilkent University, 2020-09)Breast cancer (BC) is responsible for the highest mortality and morbidity out of all the cancers in women which is primarily due to both inter and intra-tumoral molecular heterogeneity. This heterogeneity arises from ... -
Prediction of prognosis and chemosensitivity in gastrointestinal cancers
(Bilkent University, 2017-12)Colon and gastric cancers are the third and fifth cancer types with the poorest survival. Surgery is considered the primary treatment option, which can be curative. However the decision as to whether chemotherapy ... -
Prevention of fatty acid-induced inflammasome activation by a bioactive lipokine
(Bilkent University, 2014) -
The primary cilia of the gastrointestinal tract in homeostasis and disease at the single-cell level
(Bilkent University, 2021-07)The gastrointestinal tract is regularly renewed by stem cells which divide and differentiate into functionally and morphologically distinct cell types. Several key pathways, such as Wnt, Hedgehog and Bmp, regulate the cell ... -
Production of recombinant human beta-catenin protein in Ecoli and screening for anti-beta-catenin
(Bilkent University, 2000)The p-catenin gene is a component of wnt pathway involved in developmental pattern formation. The protein product is involved in both cell-cell interaction through E- cadherin and gene regulation through Tcf transcription ... -
Production of recombinant human BRCA1 encoded proteins in E coli
(Bilkent University, 1997)Among the risk factors that cause breast cancer, heredity emerges as the major determinant. BRCAl is the first gene which was found to be associated with inherited early-onset breast cancer. BRCAl is spread over a 100 kb ... -
Production of recombinant human BRCA2 encoded proteins in Ecoli
(Bilkent University, 1997)Breast cancer is known to be the most common cancer among women in the world. It is assumed that one in ten women will develop breast cancer till the age 80. Heredity is the major risk determinant in breast cancer. 30% of ... -
qPCR validation of in vivo diagnostic importance and regulation by estrogen for CHRNA5 isoform expression in breast cancer
(Bilkent University, 2014)Breast cancer has multiple molecular subtypes; normal-like, basal-like, luminal A, luminal B and HER2 positive depending on receptor status of tumor cells. Cancer therapy is tailored according to the type of cancer; hence ... -
Quadrupedal gait in humans : identification and partial characterization of a novel gene WD repeat domain 81 (WDR81)
(Bilkent University, 2011)Identi cation of disease genes responsible for cerebellar phenotypes provides mechanistic insights into the development of cerebellum. Neural pathways involved in bipedal gait in humans is not completely understood. ... -
Reactivation of telomerase reverse transcriptase gene in liver cancer
(Bilkent University, 2014-09)Hepatocellular Carcinoma (HCC) is one of the major causes of cancer related deaths worldwide and its incidence has been increasing drastically, especially in western countries. HCC has a heterogeneous molecular and ... -
Reconstitution of RNA Polymerase II subunits and analysis of their interaction with PIC components
(Bilkent University, 2018-08)Mediator Complex is a global coactivator of RNA Pol II transcription machinery. It transmits the regulatory signals from enhancer to promoter region. In the absence of Mediator Complex, Pol II transcription is defected. ... -
Reconstitution of the partial tail module of the human mediator complex
(Bilkent University, 2021-09)RNA Polymerase II (Pol II) regulates and maintains every aspect of the cell through the act of transcription of protein coding genes. Transcription of protein coding genes depends on extrinsic and intrinsic signals to the ... -
Regulation of human monocyte differentiation into m1- and m2-like macrophages
(Bilkent University, 2016-05)Myeloid-derived suppressor cells (MDSC) play a key role in down-regulating activated T and NK cells. MDSC are emerging as targets for cancer immunotherapy since they protect tumor cells from immune elimination. We ... -
Regulation of mineralocorticoid receptor and its downstream targets by estrogen and aldosterone in breast cancer
(Bilkent University, 2016-11)Many women suffer from breast cancer worldwide thus accurate diagnosis of this disease has become an important issue for treatment options and improved clinical outcomes. Members of steroid hormone receptors, are a subfamily ... -
Revealing the role of Med14 in Pol-II transcription regulation
(Bilkent University, 2017-08)Transcription of protein coding genes by RNA polymerase II (Pol II) is a multi-step process each of which requires a series of factors including coactivators. 30-subunit (the subunits are organized into discrete modules ...
