Browsing Theses - Department of Molecular Biology and Genetics by Title
Now showing items 143-162 of 224
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Large-scale manufacturing and characterization of a Sars Cov-2 virus-like particle vaccine adsorbed onto alhydrogel and adjuvanted with k3 cpg oligodeoxynucleotide for use in phase 1/2 clinical trials
(Bilkent University, 2022-04-28)Emergence of COVID-19 pandemic has been met by an exceptionally fast response from vaccine makers around the globe. Vaccines that elicit excellent immunological responses against SARS-CoV-2 are now widely utilized. ... -
Liposome encapsulation overcomes d-type and k-type CpG ODN dichotomy and induces synergistic immune activation = Lipozoma yüklenmiş D-tipi ve K-tipi ODN'lerin sinerjik immun aktivasyonu
(Bilkent University, 2014)Liposomes are one of the best candidates for the encapsulation of labile bioactive agents due to their safety and high entrapment efficiency. In human, two structurally distinct classes of CpG ODN are capable of activating ... -
Lipotoxic endoplasmic reticulum stress-associated inflammation : molecular mechanisms and modification by a bioactive lipokine
(Bilkent University, 2012)Physiologic or pathologic processes that disturb protein folding in the endoplasmic reticulum (ER) activate a signaling pathway named the unfolded protein response (UPR). UPR promotes cell survival by reducing misfolded ... -
Liver regeneration : potential roles of mesenchymal stem cells and toll like receptors
(Bilkent University, 2008)Akçalı -
Mechanisms of SSX gene expression regulation at the promoter level
(Bilkent University, 2009)Cancer Testis (CT) Antigen Genes are not transcribed in any of the adult tissues except spermatogonia, oogonia and trophoblasts. This tight regulation of expression is reversed resulting in the reactivation of CT ... -
Metastasis suppressor genes and proteins in non-melanoma skin cancers
(Bilkent University, 2014-09)Skin cancers are the most common cancer in human population. They are practically divided into two major group; melanoma and non-melanoma skin cancer (NMSC). NMSC often refers to two common neoplasms; cutaneous squamous ... -
Mirna based identification of prostate cancer by investigation of urinary exosomes
(Bilkent University, 2020-08)Prostate cancer is one of the most incident cancer subtypes with high mortality rate. Currently, diagnosis of prostate cancer is based on rectal examination, Prostate Specific Antigen (PSA) testing and biopsy. Normal range ... -
miRNA-mRNA interaction network regulating chemotherapy resistance in triple negative breast cancer
(Bilkent University, 2019-06)Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, lacking the expression of the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). ... -
Modeling cellular processes with PATİKA
(Bilkent University, 2001)Availability of the sequences of entire genomes shifts the scientific curiosity toward the identification of function of the genomes in large scale as in genome studies. In the near future data produced about cellular ... -
Molecular analyses of hematological malignancies
(Bilkent University, 1998)Normal hematopoiesis is known to be disrupted in hematological malignancies. As research advances, many new treatment techniques are introduced, among which allogeneic transplantation is the most effective. In patients who ... -
Molecular analysis of senescence-associated protein phosphatases DUSP10 and MTMR11
(Bilkent University, 2009)Liver cancer is the fifth most common cancer in the world. Until recently, tumor cells were thought to proliferate indefinitely. In a previous study, our group showed spontaneous induction of replicative senescence in ... -
Molecular characterization of the ATPase component of a putative ABC type transporter in moraxella catarrhalis
(Bilkent University, 2004)Moraxella catarrhalis is one of the major causes of respiratory tract and middle ear infections. Little is known about the pathogenesis of M. catarrhalis infection. A pathogenic bacterium requires adherence, invasion, ... -
Molecular cloning and characterization of the common 1b subtype of HCV from Turkey
(Bilkent University, 1999)Hepatitis C Virus is a major cause of acute and chronic hepatitis worldwide. 80-90% of Hepatitis C Virus infections become chronic and 75% of these cases lead to liver disease, including cirrhosis, liver failure and ... -
Molecular karyotyping of human hepatocellular carcinoma cell lines using single-nucleotide polymorphism arrays
(Bilkent University, 2007)Hepatocellular carcinoma (HCC) etiology is genetically heterogeneous; multiple different mechanisms have been shown to promote hepatocarcinogenesis. However, chromosomal aberrations (CAs) and signaling pathways that they ... -
Molecular mechanism for adenosine regulation of dendritic cells
(Bilkent University, 2017-05)Cell death, inflammation or other cellular stress factors cause accumulation of adenosine in the extracellular space. Adenosine has immunosuppressive effects on antigen presenting cells. However, molecular mechanisms for ... -
Molecular mechanisms of adenosine regulation of helper T cell responses
(Bilkent University, 2017-05)Polarizations of helper T cells into different functional subsets is important in order to influence the progression of immune-related diseases. One of the major outcomes in immune cell activation and generation of immunogenic ... -
Molecular mechanisms of PI3K isoform dependence in carcinogenesis
(Bilkent University, 2020-12)PI3K pathway is important for cellular proliferation, survival and metabolism. PTENloss and activating mutations of PIK3CA are most frequently seen PI3K related alterations in various cancer types. Activating mutations ... -
Molecular mechanisms of senescence response to transforming growth factor-beta in liver cancer
(Bilkent University, 2010)Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. HCC is associated with several etiological factors including infections with hepatitis B and C viruses, heavy alcohol consumption and chronic ... -
Monoclonal antibody production for coiled-coil domain containing-124 (CCDC-124) and its molecular characterization
(Bilkent University, 2010)Coiled-coil-domain-containing-124 (CCDC-124) is a novel protein of unknown function. The Ccdc-124 gene is highly conserved among eukaryotic species and is predicted to encode a 223 amino acids long protein. Yeast-two-hybrid ... -
Multiomics approaches to overcome drug resistance in cancer
(Bilkent University, 2021-09)Chemotherapy resistance remains one of the major challenges in cancer treatment. Most of the studies on drug resistance have focused on genetic evolution of cancer cells; however, this focus has shifted to non-genetic and ...
