Browsing Theses - Department of Molecular Biology and Genetics by Title
Now showing items 77-96 of 224
-
Functional analysis of Erbin gene in breast cancer drug resistance
(Bilkent University, 2021-02)Erbin is an ERBB2 interacting protein with roles in many signaling pathways. Breast cancer is one of the types of cancer that is affected by Erbin regulation. However, it is unclear how Erbin regulates the biological ... -
Functional analysis of transgelin in breast cancer
(Bilkent University, 2018-06)Transgelin (TAGLN) is an actin-binding protein. It is highly expressed in fibroblasts and smooth muscle cells. In smooth muscle cells, it takes part in processes including motility and differentiation and also it has a ... -
Functional characterization of LOC115098:A novel gene conserved in eukaryotic genomes
(Bilkent University, 2007)Loc115098 is a newly identified gene in our laboratory. The gene was firstly discovered in an unrelated study in which the cis-acting regulatory elements of a neighboring gene NIS (Sodium-Iodide Symporter) were investigated. ... -
Functional effects of ATAD2 gene expression in breast cancer
(Bilkent University, 2016-08)The ATAD2 gene is a newly investigated gene of which the expression levels are associated with the disease prognosis in many types of cancer and especially breast cancer and that is known to be overexpressed usually through ... -
Functional identification of RASGEF1 family of exchange factors as activators of RAP2, and as interacting partners of CCDC124
(Bilkent University, 2009)Coiled coil domain-124 gene is highly conserved among eukaryotes and the human counterpart encodes a protein with no domain similarities with any previously characterized eukaryotic proteins. In this study, we aimed to ... -
Gene expression profiling of hedgehog pathway genes in epithelial cancers
(Bilkent University, 2006)The Hedgehog (Hh) signaling pathway has been investigated in many cancer types and shown to have important effects, but not effectively studied in breast, colon and liver cancers. In this study, gene expression profile ... -
Genetic analysis of Smad2 gene in hepatocellular carcinoma
(Bilkent University, 1998)Hepatocellular carcinoma is one of the most malignant cancers and is the most frequent one in some regions in the world. Although it is a multistage disease, its genetic composition is not well understood. TGF(3 is shown ... -
Genetic analysis of Smad4 gene in TGF-Beta signalling pathway in human liver cancer
(Bilkent University, 1998)HCC is a multistep genetic disease in which many genomic changes occur as a result of uncontrolled proliferation of hepatocytes. Molecular events leading to HCC is still unclear. Until now, neither an oncogene nor a tumor ... -
Genetic and epigenetic analysis of immortal and senescence arrested liver cancer cells
(Bilkent University, 2009)Genetic and epigenetic aspects of cellular senescence and immortality in hepatocellular carcinoma (HCC) are poorly elucidated. The aim of our thesis was to characterize senescence and immortality gene network (SIGN) ... -
Genetic and epigenetic effect of estrogen on mesenchymal stem cell maintenance and differentiation
(Bilkent University, 2013)Mesenchymal stem cells (MSCs) have the potential to differentiate into multiple cell types and immune privileged characteristics. These features make MSCs a hope in tissue engineering and cell based treatment ... -
Genetic and epigenetic evaluation of the candidate genes in human hepatocellular carcinomas
(Bilkent University, 2010)Hepatocellular carcinoma (HCC) is the fifth most-common cancer and the third most common cause of cancer related mortality worldwide. HCC is also the most common type of liver cancer. Hepatocarcinogenesis is a multistep ... -
Genetic and epigenetic targets in liver cancer
(Bilkent University, 2010)Hepatocellular carcinoma (HCC) kills nearly 600.000 people each year and the only effective therapy for this cancer is liver transplantation or tumor ablation only when the tumor is small enough. These tumors are surprisingly ... -
Hanein-1, a novel conserved eukaryotic protein ubiquitously expressed in human tissues
(Bilkent University, 2008)HANEIN-1 was first identified in a study investigating 3’ transcriptional regulatory elements of the Na+ /I- symporter gene. The protein is highly conserved among eukaryotes and bears no domain similarities with any ... -
Hepatocellular carcinoma viral etiology and molecular mechanisms
(Bilkent University, 2003)Hepatocellular carcinoma (HCC) is one of the most frequent carcinomas throughout the world, being responsible for more than 1 million deaths annually and has a strong association with several etiological factors including ... -
Heterogeneity of hepatocellular malignant phenotype
(Bilkent University, 2006)Hepatocellular carcinoma (HCC) is one of the most wide-spread carcinomas throughout the world - responsible for more than 600,000 deaths annually - and is strongly associated with several etiological factors; including ... -
Histone methylation and methyltransferase enzyme Set8 in hepatocellular carcinoma
(Bilkent University, 2010)Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers worldwide. The epigenetic modifications, which are involved in virtually all cellular processes are also involved in the carcinogenic process, ... -
hsa-miR-497 as a modulator of the expression in the presence or absence of chrna5 in breast cancer
(Bilkent University, 2017-06)CHRNA5 is an important ligand-gated receptor with roles in addiction and in cancer. In lung cancer, CHRNA5 dysregulation is well known. There is also expression of CHRNA5 in breast cancer cell lines. microRNAs regulate ... -
Identification and characterization of two endoplasmic reticulum protein isoforms encoded by senescence-associated FAM134B gene
(Bilkent University, 2008)Liver cancer is the fifth most common cancer in the world. Until recently, tumor cells were known to have the capacity to proliferate indefinitely. In a previous study, we showed the spontaneous induction of replicative ... -
Identification and the characterization of small molecules with potential anticancer activity against solid tumors
(Bilkent University, 2011)The ultimate goal of our project was to investigate candiate small molecules with a potential anticancer activity and characterize their mode of action. Cardiac glycosides are important group of molecules for both their ... -
Identification and utilization of autologous anti-tumor antibodies for the diagnosis and prognosis of cancer
(Bilkent University, 2015-12)Lung cancer is the leading cause of cancer related death worldwide. Current diagnostic methods have limited power and unable to extend patient life significantly. SCLC; the most aggressive subtype of lung cancer is an ...
