Browsing Theses - Department of Molecular Biology and Genetics by Title
Now showing items 54-73 of 224
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E2F1-Induced expression of transactivating and dominant-negative forms of p73 transcripts
(Bilkent University, 2002)Cell cycle, one of the most important life processes, is controlled by a regulated balance between proliferative and anti-proliferative signals. Dysregulation of these signals leads to tumor development. Retinoblastoma ... -
Early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair
(Bilkent University, 2014)Characterizing the patterns and rate of de novo mutations is crucial for our perception of evolution and genetic basis of human disease. Direct observation of de novo single nucleotide variation (SNV) rate in healthy ... -
Effect of estrogen on apoptotic regulatory mechanisms in mesenchymal stem cell maintenance
(Bilkent University, 2006)Mesenchymal Stem Cells (MSCs) can both self-renew and differentiate into fat, bone, cartilage, and muscle. They have a high therapeutic value due to their differentiation potential and nonimmunogenic characteristics, ... -
The effect of interleukin 7 on CD8+T cell accumulation and differentiation in the presence of adenosine signaling
(Bilkent University, 2020-01)Cytotoxic T cells are important cytotoxic adaptive immune cells. Their role is to check every single cell for protecting the body against microbial infections. They are also the main players for antigen-specific recognition ... -
Effects of biological compound Turkish propolis extract on breast cancer cells
(Bilkent University, 2013)Propolis is a resinous compound which is collected from various plants then combined with wax and bee enzymes by worker bees. There are many studies conducted on propolis or its active components aiming to find new ... -
Effects of Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi on apoptosis, DNA damage response, drug sensitivity, and HSA-MIR-495-3P overexpression in breast cancer
(Bilkent University, 2018-12)Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is associated with nicotine addiction and it has an important role in the prognosis of lung cancer. Despite its important cellular functions, its role in breast cancer remains ... -
Effects of miR-376 family miRNAs on CHRNA5 depleted MCF7 cell line model and co-culture competition studies
(Bilkent University, 2019-07)Cholinergic receptor nicotinic alpha 5 (CHRNA5) is a ligand-gated ion channel and one of the subunits of nicotinic acetylcholine receptors. Role of CHRNA5 in tumorigenesis has been initially shown in the lung tissue in ... -
Effects of PI3K/AKT/MTOR and VEGFR pathway inhibitors on liver cancer stem cells and bioactivities of novel pyrazolic chalcone derivatives on liver cancer
(Bilkent University, 2017-12)Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality, such that it the second most frequent cause of cancer death worldwide. Due to its heterogeneous composition and aggressive behavior, ... -
Effects of rapamycin on the early development of zebrafish (Danio rerio)
(Bilkent University, 2004)Rapamycin, isolated from the soil bacteria Streptomyces hygroscopicus as an antibiotic, previously was shown to have negative effects on the immune system, cancer development, and cell cycle using different model organisms. ... -
Elucidating immunomodulatory effects of telomeric repeat mimicking synthetic A151 oligodeoxynucleotide on immune cell transcriptome
(Bilkent University, 2019-09)Recent evidence revealed that DNA is beyond just the blueprint of life; it is also involved in immunomodulation. Unmethylated Cytosine-phosphate-Guanine (CpG) motifs of prokaryotic DNA stimulate immune response by ... -
Elucidation of Sorafenib resistance mechanisms in hepatocellular carcinoma
(Bilkent University, 2018-07)Hepatocellular Carcinoma (HCC) is the sixth most common type of cancer and the second leading cause of cancer-related deaths worldwide. Currently, Sorafenib is the only approved first-line treatment option for unresectable ... -
Enhanced immunomodulatory applications of nucleic acid encapsulating liposomes
(Bilkent University, 2009)Recent studies have demonstrated that innate immune system has great ability to discriminate self from non-self through the action of innate immune receptors. The most extensively studied innate immune receptor family ... -
Epigenetic regulation of cancer-testis gene expression
(Bilkent University, 2008)Cancer-testis (CT) genes are composed of mostly X-linked gene families that are widely expressed in cancer, in a coordinate manner, with ideally no expression in normal tissues except spermatogonia, oogonia and trophoblasts. ... -
Epigenetic regulation of SLIT-ROBO pathway in hepatocellular carcinoma
(Bilkent University, 2009)Hepatocellular carcinoma is an aggressive, chemotherapy-resistant cancer and the prognosis of affected patients is very poor. Therefore, unraveling molecular components of hepatocarcinogenesis not only leads to the ... -
Establishment of a rapid mutation detection technique for screening of BRCA1 and BRCA2 genes
(Bilkent University, 1997)People bearing germline mutations in either BRCAl or BRCA2 genes are more prone to breast cancer than other people. These two recently identified genes account for nearly 90% of the hereditary cancer cases. This number ... -
Establishment of an experimental system to study p53 effects in Saccharomyces cerevisiae
(Bilkent University, 1997)The aim of this vv^ork was to establish an experimental model to study human wild type and mutant p53 protein effects in yeast Saccharomyces cerevisiae cells. Wild type p53 was previously shown to be a DNA damage response ... -
Evaluation of C/EBP(formula) as a candidate tumor suppressor gene in hepatocellular carcinoma
(Bilkent University, 2004)Hepatocellular carcinoma (HCC) is the fifth common type of cancer and third leading cause of cancer deaths in the world. HCC is a genetically heterogeneous disease and multiple pathways and molecules are identified to ... -
Evaluation of TAGLN as a diagnostic marker in breast cancer
(Bilkent University, 2018-08)Silecing of tumor suppressor genes via CpG hypermethylation in promoter regions is one of the frequent events occurring in different types of cancers. These genes have the potential as a diagnostic or a prognostic ... -
Evidence for a novel bacteriophage from moraxella catarrhalis
(Bilkent University, 2005)Moraxella catarrhalis is one of the major causes of RTI and otitis media, which was known as a harmless inhabitant of upper respiratory tract until 1980s. The knowledge on virulence factors, pathogenesis of this bacterium ... -
Expression and purification of the hepatitis C virus core protein in Ecoli and testing of human sera with this core antigen
(Bilkent University, 1998)The hepatitis C virus (HCV) infection is an important cause of morbidity and mortality world wide. Infection with HCV becomes chronic in more than 80% of the cases and it accounts for 20%of all cases of acute hepatitis. ...
