Browsing Theses - Department of Molecular Biology and Genetics by Title
Now showing items 44-63 of 224
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Deciphering IKBKE involvement in hepatocellular cancer HEPG2 cells
(Bilkent University, 2020-06)Hepatocellular carcinoma (HCC) is the second leading cause of cancer related deaths worldwide. The reasons behind high mortality in HCC patients include late diagnosis and lack of therapeutic option. Sorafenib is the only ... -
Development and validation of methods for the diagnosis of lung cancer via serological biomarkers
(Bilkent University, 2019-02)Over 10% of all new cancer cases are lung cancer. Moreover, estimates till 2030 indicate that already increasing lung cancer incidences will keep increasing, especially in developing countries like Turkey. Lung cancer, the ... -
Development of a non-immunological system for the study of the cellular localization of BRCA1 gene product in living cells
(Bilkent University, 1997)BRCAl, is a familial breast and ovarian cancer susceptibility gene that has been cloned and shown to be either lost or mutated in families with breast and ovarian cancer. BRCAl, has been postulated to encode a tumor ... -
Development of a non-radioactive diagnostic test for the detection of microsatellite instability in colorectal cancer
(Bilkent University, 1997)Stepwise accumulation o f mutations in the human genome is the initial step in carcinogenesis. Microsatellites are the regions which are first hit by the mutations resulting from mismatch repair deficiency. Until today ... -
Development of a specialized zebrafish xenotransplantation database and establishment of ALU-based tumor DNA quantification method in zebrafish: focus on models of overexpression and microenvironment
(Bilkent University, 2020-09)Successful xenotransplantation of human cancer cells into zebrafish host marked a new era in cancer research enabling high throughput in vivo screens. Zebrafish xenotransplantation literature continues to rapidly accumulate, ... -
Development of a WEB application
(Bilkent University, 2011)microRNAs, small non-coding RNA molecules with important roles in cellular machinery, target mRNAs for silencing by binding generally to their 3’ UTR sequences via partial base complementation. Thus, microRNAs with ... -
Development of methods for identification and characterization of autologous antibody responses in Small Cell Lung Cancer and Behcet’s Disease
(Bilkent University, 2016-08)Autologous antibodies are known to be elicited in Behçet’s Disease (BD) and Small Cell Lung Cancer (SCLC). SCLC consists 15-20% of all lung cancer cases. It is follows a most aggressive course and generally patients are ... -
Development of novel tools for cancer diagnosis, prognosis and treatment using intra- or inter-species transcriptome metaanalysis
(Bilkent University, 2017-08)In the past decades, a considerable number of studies have performed meta-analysis on large data collections to prioritize sets of genes, pathways or types/categories of disease focusing on either differential expression, ... -
Differentiation of hepatocyte like cells from immortalized mouse embryonic fibroblasts harboring large T antigen
(Bilkent University, 2015)Genetic and acquired liver diseases are generally progressive and life threatening with limited curative therapy options. Although organ transplantation is the most potent treatment, number of patients waiting for organ ... -
Discovery of novel agents for liver cancer therapeutics and characterization of their bioactivities on cellular pathways
(Bilkent University, 2015-12)Hepatocellular carcinoma is the second deadliest and fifth most common cancer type worldwide. Due to the limited therapy options, it is crucial to develop novel targeted therapeutic agents that provide better prognosis ... -
E2F1-Induced expression of transactivating and dominant-negative forms of p73 transcripts
(Bilkent University, 2002)Cell cycle, one of the most important life processes, is controlled by a regulated balance between proliferative and anti-proliferative signals. Dysregulation of these signals leads to tumor development. Retinoblastoma ... -
Early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair
(Bilkent University, 2014)Characterizing the patterns and rate of de novo mutations is crucial for our perception of evolution and genetic basis of human disease. Direct observation of de novo single nucleotide variation (SNV) rate in healthy ... -
Effect of estrogen on apoptotic regulatory mechanisms in mesenchymal stem cell maintenance
(Bilkent University, 2006)Mesenchymal Stem Cells (MSCs) can both self-renew and differentiate into fat, bone, cartilage, and muscle. They have a high therapeutic value due to their differentiation potential and nonimmunogenic characteristics, ... -
The effect of interleukin 7 on CD8+T cell accumulation and differentiation in the presence of adenosine signaling
(Bilkent University, 2020-01)Cytotoxic T cells are important cytotoxic adaptive immune cells. Their role is to check every single cell for protecting the body against microbial infections. They are also the main players for antigen-specific recognition ... -
Effects of biological compound Turkish propolis extract on breast cancer cells
(Bilkent University, 2013)Propolis is a resinous compound which is collected from various plants then combined with wax and bee enzymes by worker bees. There are many studies conducted on propolis or its active components aiming to find new ... -
Effects of Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi on apoptosis, DNA damage response, drug sensitivity, and HSA-MIR-495-3P overexpression in breast cancer
(Bilkent University, 2018-12)Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is associated with nicotine addiction and it has an important role in the prognosis of lung cancer. Despite its important cellular functions, its role in breast cancer remains ... -
Effects of miR-376 family miRNAs on CHRNA5 depleted MCF7 cell line model and co-culture competition studies
(Bilkent University, 2019-07)Cholinergic receptor nicotinic alpha 5 (CHRNA5) is a ligand-gated ion channel and one of the subunits of nicotinic acetylcholine receptors. Role of CHRNA5 in tumorigenesis has been initially shown in the lung tissue in ... -
Effects of PI3K/AKT/MTOR and VEGFR pathway inhibitors on liver cancer stem cells and bioactivities of novel pyrazolic chalcone derivatives on liver cancer
(Bilkent University, 2017-12)Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality, such that it the second most frequent cause of cancer death worldwide. Due to its heterogeneous composition and aggressive behavior, ... -
Effects of rapamycin on the early development of zebrafish (Danio rerio)
(Bilkent University, 2004)Rapamycin, isolated from the soil bacteria Streptomyces hygroscopicus as an antibiotic, previously was shown to have negative effects on the immune system, cancer development, and cell cycle using different model organisms. ... -
Elucidating immunomodulatory effects of telomeric repeat mimicking synthetic A151 oligodeoxynucleotide on immune cell transcriptome
(Bilkent University, 2019-09)Recent evidence revealed that DNA is beyond just the blueprint of life; it is also involved in immunomodulation. Unmethylated Cytosine-phosphate-Guanine (CpG) motifs of prokaryotic DNA stimulate immune response by ...
