Browsing Theses - Department of Molecular Biology and Genetics by Title
Now showing items 1-20 of 224
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The ability to generate differentiated and senescent progeny is a major determinant of breast cancer heterogeneity
(Bilkent University, 2009)Breast cancer displays distinct subtypes, such as luminal A, luminal B, and basallike. The prognosis and therapeutic response of each subtype is different. The mechanisms involved in the generation of these tumor types ... -
Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells
(Bilkent University, 2002)P53 gene is the most common mutated tumor suppressor gene during tumorigenesis. From its description till 1997, p53 gene was thought to stand alone in the human genome. In 1997, p73 gene and in 1998, p63 gene was identified ... -
Acquired tolerance of hepatocellular carcinoma cells to selenium-deficiency : a selective survival mechanism
(Bilkent University, 2003)Selenium-deficiency causes liver necrosis. Selenium is protective against viral hepatitis and hepatocellular carcinoma (HCC). The underlying molecular mechanisms of selenium effects are ill-known. In this study in vitro ... -
Adenosine regulation of danger signaling
(Bilkent University, 2017-07)Metabolic and immune related activities converge as main triggers of adenosine accumulation in extracellular space. Adenosine by engaging adenosine A2A and A2B receptors strongly suppresses innate and adaptive immune ... -
Analyses and web interfaces for protein subcellular localization and gene expression data
(Bilkent University, 2007)In order to benefit maximally from large scale molecular biology data generated by recent developments, it is important to proceed in an organized manner by developing databases, interfaces, data visualization and data ... -
Analysis of 45S rDNA promoter methylation and expression of rRNA transcripts in breast cancer
(Bilkent University, 2015-06)Ribosome biogenesis has a central role in cell growth and proliferation that is usually disrupted in tumor cells by the inactivation of tumor suppressor genes and activation of oncogenes. Ribosomal RNA (rRNA) gene expression ... -
Analysis of BRCA1 and BRCA2 genes in Turkish breast cancer patients
(Bilkent University, 2000)Breast cancer is the most frequent cancer type and the second cause of death among women. It is estimated that 10 to 15% of breast cancer cases are hereditary. The majority of hereditary breast cancers can be attributed ... -
Analysis of candidate molecular targets in adult (CML) and childhood (AML, ALL) Leukemias
(Bilkent University, 2004)Candidate molecular targets were investigated in three different types of leukemias, chronic myeloid leukemia (CML), acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL). The first group of these molecular ... -
Analysis of CHRNA5 expression in breast cancer cell lines in response to serum starvation and estrogen treatment
(Bilkent University, 2013)Breast cancer is a complex disease that can be classified into distinct molecular subtypes including Basal, Luminal A, Luminal B and HER2 positive. These molecular subtypes mainly differ in their hormone receptor ... -
Analysis of differentially expressed geExpression of notch signaling pathway recenes in breast cancer : BRCA1- induced gene expression profiles and meta-analysis gene signature
(Bilkent University, 2009)The aim of the first part of this study was to find out the expression profiles of the genes, which were selected from the former BRCA1-induced gene list (OVCA1, OVCA2, ERBIN, RAD21, XRN2, RENT2, SMG1 and MAC30) in ... -
Analysis of GSTM1, GSTT1, GSTP1, and TP53 polymorphisms as genetic risk factors for bladder cancer in the Turkish population
(Bilkent University, 2001)The effect of the GSTM1 and GSTT1 null genotypes, the GSTP1 Ile105Val, and TP53 Arg72Pro polymorphism on bladder cancer susceptibility was investigated in a case control study of 121 bladder cancer patients, and 121 ... -
Analysis of hMLH1 germline mutations in three Turkish hereditary nonpolyposis colorectal cancer kindreds
(Bilkent University, 1998)Hereditary nonpolyposis colorectal cancer (HNPCC) is one of the most common genetic diseases in Western world. It is a clinical syndrome characterized by an inherited predisposition to early onset colorectal and an increased ... -
Analysis of LSAMP gene as a tumor suppressor in neuroblastoma
(Bilkent University, 2009)Neuroblastoma constitutes approximately 10 % of all childhood tumors with a worldwide considerable morbidity and mortality. Frequently, in children under the age of 1, it can spontaneously regress and transform into a ... -
Analysis of MECP2 gene mutations in Rett syndrome patients
(Bilkent University, 2001)Rett Syndrome (RTT) is a progressive X-linked dominant childhood neurodevelopmental disorder, affecting 1/10,000-15,000 girls. The disease-causing gene was identified as MECP2 on chromosome Xq28, and mutations have been ... -
Analysis of members of the SLIT-ROBO pathway as diagnostic and prognostic tools in hepatocellular carcinoma with special focus on ROBO2-associated cellular phenotype
(Bilkent University, 2009)Hepatocellular carcinoma is the sixth most common cancer in the world, with an annual incidence exceeding half a million. It is associated mainly with hepatitis B and C viral infections; and is the main cause of death ... -
Analysis of p73 gene in hepatocellular carcinoma
(Bilkent University, 1998)Hepatocellular carcinoma (HCC) is the eighth most frequent cancer worldwide, iipidemiologically-studied risk factors include hepatitis B virus (greater than 80%), hepatitis C virus and aflatoxins. Molecular mechanisms of ... -
Analysis of the ATAD2 gene effect on the genes involved in epithelial mesenchymal transition in estrogen positive and negative breast cancers
(Bilkent University, 2021-02)ATAD2 is overexpressed in many distinct cancer types including breast cancer. Its elevated expression is an indicator of poor prognosis. High ATAD2 expression correlates with short overall survival, disease-free survival ... -
Analysis of the function of the nuclear matrix-associated protein C1D
(Bilkent University, 1999)DNA Double-strand breaks (DSBs) are generated as intermediate stnictures during V(D)J recombination, as a consequence of oxidative metabolism, or can be induced by exogenous factors such as gamma irradiation and radiomimetic ... -
Analysis of tumor suppressor genes in testis cancer
(Bilkent University, 1998)At least two classes of genes are involved directly or indirectly in the regulation of cell growth and differentiation. One group of these genes, known as tumor suppressor genes, is involved in cellular regulation by ... -
Analysis of X chromosome inactivation in primary and secondary Sjogren syndrome
(Bilkent University, 2008)Sjogren Syndrome is an autoimmune disease with one of the highest prevalences and unknown etiology. The majority of the patients (~90%) are female similar to several other autoimmune diseases. Based on this observation, ...
