Recent Submissions

  • SIK2 attenuates proliferation and survival of breast cancer cells with simultaneous perturbation of MAPK and PI3K/Akt pathways 

    Zohrap, N.; Saatci, Özge; Özeş, B.; Çoban, İ.; Atay, H. M.; Battaloğlu, E.; Şahin, Özgür; Buğra, K. (Impact Journals LLC, 2018)
    Salt Inducible Kinase2 (SIK2) has been shown to contribute to tumorigenesis in multiple tumor types in a dichotomous manner. However, little is known about its contribution to breast malignancies. Here, we report SIK2 as ...
  • Autoantibodies against type I IFNs in patients with life-threatening COVID-19 

    Bastard, P.; Rosen, L. B.; Zhang, Q.; Michailidis, E.; Hoffmann, H.-H.; Zhang, Y.; Dorgham, K.; Philippot, Q.; Rosain, J.; Béziat, V.; Manry, J.; Shaw, E.; Haljasmägi, L.; Peterson, P.; Lorenzo, L.; Bizien, L.; Trouillet-Assant, S.; Dobbs, K.; Almeida de Jesus, A.; Belot, A.; Kallaste, A.; Catherinot, E.; Tandjaoui-Lambiotte, Y.; Le Pen, J.; Kerner, G.; Bigio, B.; Seeleuthner, Y.; Yang, R.; Bolze, A.; Spaan, A. N.; Delmonte, O. M.; Abers, M. S.; Aiuti, A.; Casari, G.; Lampasona, V.; Piemonti, L.; Ciceri, F.; Bilguvar, K.; Lifton, R. P.; Vasse, M.; Smadja, D. M.; Migaud, M.; Hadjadj, J.; Terrier, B.; Duffy, D.; Quintana-Murci, L.; van de Beek, D.; Roussel, L.; Vinh, D. C.; Tangye, S. G.; Haerynck, F.; Dalmau, D.; Martinez-Picado, J.; Brodin, P.; Nussenzweig, M. C.; Boisson-Dupuis, S.; Rodríguez-Gallego, C.; Vogt, G.; Mogensen, T. H.; Oler, A. J.; Gu, J.; Burbelo, P. D.; Cohen, J. I.; Biondi, A.; Bettini, L. R.; D'Angio, M.; Bonfanti, P.; Rossignol, P.; Mayaux, J.; Rieux-Laucat, F.; Husebye, E. S.; Fusco, F.; Ursini, M. V.; Imberti, L.; Sottini, A.; Paghera, S.; Quiros-Roldan, E.; Rossi, C.; Castagnoli, R.; Montagna, D.; Özçelik, Tayfun; Licari, A.; Marseglia, G. L.; Duval, X.; Ghosn, J.; Tsang, J. S.; Goldbach-Mansky, R.; Kisand, K.; Lionakis, M. S.; Puel, A.; Zhang, S.- Y.; Holland, S. M.; Gorochov, G.; Jouanguy, E.; Rice, C. M.; Cobat, A.; Notarangelo, L. D.; Abel, L.; Su, H. C.; Casanova, J. L.; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort (2020)
    Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease ...
  • Discovering competing endogenous RNA interactions in breast cancer molecular subtypes 

    Olgun, Gülden; Şahin, Özgür; Taştan, Öznur (Springer, 2018)
    Background: Long non-coding RNAs (lncRNAs) can indirectly regulate mRNAs expression levels by sequestering microRNAs (miRNAs), and act as competing endogenous RNAs (ceRNAs) or as sponges. Previous studies identified ...
  • A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection 

    Casanova, J.-L.; Su, H. C.; Abel, L.; Aiuti, A.; Almuhsen, S.; Arias, A. A.; Bastard, P.; Biggs, C.; Bogunovic, D.; Boisson, B.; Boisson-Dupuis, S.; Bolze, A.; Bondarenko, A.; Bousfiha, A.; Brodin, P.; Bustamante, J.; Butte, M.; Casari, G.; Ciancanelli, M.; Cobat, A.; Condino-Neto, A.; Cooper, M.; Dalgard, C.; Espinosa, S.; Feldman, H.; Fellay, J.; Franco, J. L.; Hagin, D.; Itan, Y.; Jouanguy, E.; Lucas, C.; Mansouri, D.; Meyts, I.; Milner, J.; Mogensen, T.; Morio, T.; Ng, L.; Notarangelo, L. D.; Okada, S.; Özçelik, Tayfun; Palacín, P. S.; Planas, A.; Prando, C.; Puel, A.; Pujol, A.; Redin, C.; Renia, L.; Gallego, J. C. R.; Quintana-Murci, L.; Sancho-Shimizu, V.; Sankaran, V.; Seppänen, M. R. J.; Shahrooei, M.; Snow, A.; Spaan, A.; Tangye, S.; Tur, J. P.; Turvey, S.; Vinh, D. C.; von Bernuth, H.; Wang, X.; Zawadzki, P.; Zhang, Q.; Zhang, S. (Elsevier, 2020)
    SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies ...
  • Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 

    Zhang, Q.; Liu, Z.; Moncada-Velez, M.; Chen, J.; Ogishi, M.; Bigio, B.; Yang, R.; Arias, A. A.; Zhou, Q.; Han, J. E.; Özçelik, Tayfun; Uğurbil, A. C.; Zhang, P.; Rapaport, F.; Li, J.; Spaan, A. N. (American Association for the Advancement of Science, 2020)
    Clinical outcomes of human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus disease 2019 (COVID-19). Epidemiological studies have identified three ...
  • Expression levels of SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) and its interacting partners show region-specific alterations during brain aging 

    Tüz-Şaşik, Melek Umay; Karoğlu-Eravşar, Elif Tuğce; Kınalı, M.; Arslan-Ergül, A.; Adams, Michelle Marie (Elsevier, 2020)
    Aging occurs due to a combination of several factors, such as telomere attrition, cellular senescence, and stem cell exhaustion. The telomere attrition-dependent cellular senescence is regulated by increased levels of SMAD ...
  • Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging 

    Erbaba, Begün; Burhan, Özge Pelin; Şerifoğlu, Naz; Muratoğlu, B.; Kahveci, Fatma; Adams, Michelle M.; Arslan-Ergül, A. (Elsevier, 2020)
    Brain aging is a complex process, which involves multiple pathways including various components from cellular to molecular. This study aimed to investigate the gene expression changes in zebrafish brains through young-adult ...
  • Ankaferd Hemostat affects etoposide resistance of the malignant melanoma cells 

    Ghasemi, M.; Okay, M.; Malkan, Ü. Y.; Türk, S.; Jabbar, Javaid; Hocaoğlu, H.; Haznedaroğlu, İ. C. (Akademi Doktorlar Yayınevi, 2020)
    The development of resistance towards chemotherapeutic drugs has become an obstacle in treatment of cancer. Ankaferd Hemostat [ABS] has shown to suppress the proliferation of melanoma cells, but little is known about its’ ...
  • Could individuals from countries using BCG vaccination be resistant to SARS-CoV-2 induced infections? 

    Ayanoğlu, İ. C.; İpekoğlu, E. M.; Yazar, Volkan; Yılmaz, İ. C.; Gürsel, İhsan; Gürsel, M. (Turkish Society of Immunology, 2020)
    The lower than expected number of SARS-CoV-2 cases in countries with fragile health systems is puzzling. Herein, we hypothesize that BCG vaccination policies and vaccine strain preferences adopted by different countries ...
  • Universality of dissipative self-assembly from quantum dots to human cells 

    Makey, Ghaith; Galioğlu, Sezin; Ghaffari, Roujin; Engin, E. D.; Yıldırım, Gökhan; Yavuz, Özgün; Bektaş, O.; Nizam, Ü. S.; Akbulut, Özge; Şahin, Özgür; Güngör, Kıvanç; Dede, Didem; Demir, Hilmi Volkan; İlday, Fatih Ömer; İlday, Serim (Nature Research, 2020)
    An important goal of self-assembly research is to develop a general methodology applicable to almost any material, from the smallest to the largest scales, whereby qualitatively identical results are obtained independently ...
  • A highly potent TACC3 inhibitor as a novel anticancer drug candidate 

    Akbulut, Özge; Lengerli, D.; Saatci, Özge; Duman, Elif; Şeker, Urartu Özgür Şafak; Işık, A.; Akyol, A.; Çalışkan, B.; Banoğlu, E.; Şahin, Özgür (NLM (Medline), 2020)
    TACC3, a transforming acidic coiled-coil (TACC) family member, is frequently upregulated in a broad spectrum of cancers, including breast cancer. It plays critical roles in protecting microtubule stability and centrosome ...
  • Author correction: CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation (Scientific Reports, (2020), 10, 1, (5971), 10.1038/s41598-020-62912-0) 

    Ayaz, G.; Razizadeh, N.; Yaşar, P.; Kars, G.; Kahraman, D. C.; Saatci, Ö.; Şahin, Özgür; Çetin-Atalay, R.; Muyan, M. (Nature Research, 2020)
  • ZenoFishDb v1.1: a database for xenotransplantation studies in zebrafish 

    Targen, Seniye; Kaya, Tuğberk; Avcı, M. E.; Güneş, Damla; Keşküş, Ayşe Gökçe; Konu, Özlen (Mary Ann Liebert, 2020)
    Rapidly accumulating literature has proven feasibility of the zebrafish xenograft models in cancer research. Nevertheless, online databases for searching the current zebrafish xenograft literature are in great demand. ...
  • Dietary and pharmacological interventions that inhibit mammalian target of rapamycin activity alter the brain expression levels of neurogenic and glial markers in an age-and treatment-dependent manner 

    Çelebi-Birand, Dilan; Ardıç, Narin İlgim; Karoğlu-Eravşar, Elif Tuğçe; Şengül, Göksemin Fatma; Kafalıgönül, Hulusi; Adams, Michelle M. (Mary Ann Liebert, 2020)
    Intermittent fasting (IF) and its mimetic, rapamycin extend lifespan and healthspan through mechanisms that are not fully understood. We investigated different short-term durations of IF and rapamycin on cellular and ...
  • Mesenchymal stem cell derived extracellular vesicles: promising immunomodulators against autoimmune, autoinflammatory disorders and SARS-CoV-2 infection 

    Bulut, Özlem; Gürsel, İhsan (Scientific and Technical Research Council of Turkey, 2020)
    Discovery of novel and broad-acting immunomodulators is of critical importance for the prevention and treatment of disorders occurring due to overexuberant immune responseincluding SARS-CoV-2 triggered cytokine storm leading ...
  • Renin angiotensin system genes are biomarkers for personalized treatment of acute myeloid leukemia with Doxorubicin as well as etoposide 

    Türk, S.; Türk, C.; Akbar, Muhammad Waqas; Küçükkaraduman, Barış; İşbilen, Murat; Demirkol-Canlı, S.; Malkan, Ü. Y.; Okay, M.; Uçar, G.; Sayınalp, N.; Haznedaroğlu, İ. C.; Güre, Ali Osmay (Public Library of Science, 2020)
    Despite the availability of various treatment protocols, response to therapy in patients with Acute Myeloid Leukemia (AML) remains largely unpredictable. Transcriptomic profiling studies have thus far revealed the presence ...
  • A novel 20-gene prognostic score in pancreatic adenocarcinoma 

    Demirkol-Canlı, S.; Dedeoğlu, Ege; Akbar, Muhammad Waqas; Küçükkaraduman, Barış; İşbilen, Murat; Şükrüoğlu-Erdoğan, Ö.; Kılıç-Erciyas, S.; Yazıcı, H.; Vural, B.; Güre, Ali Osmay (Public Library of Science, 2020)
    Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Known risk factors for this disease are currently insufficient in predicting mortality. In order to better prognosticate patients with PDAC, we ...
  • CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation 

    Ayaz, G.; Razizadeh, N.; Yaşar, P.; Kars, G.; Kahraman, D. C.; Saatci, Ö.; Şahin, Özgür; Çetin-Atalay, R.; Muyan, M. (Nature Research, 2020)
    Evidence suggests that the CXXC type zinc finger (ZF-CXXC) protein 5 (CXXC5) is a critical regulator/integrator of various signaling pathways that include the estrogen (E2)-estrogen receptor α (ERα). Due to its ZF-CXXC ...
  • Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics 

    Layeghi-Ghalehsoukhteh, S.; Choudhuri, S. P.; Öcal, Özhan; Zolghadri, Y.; Pashkov, V.; Niederstrasser, H.; Posner, B. A.; Kantheti, H. S.; Azevedo-Pouly, A. C.; Huang, H.; Girard, L.; MacDonald, R. J.; Brekken, R. A.; Wilkie, T. M. (Nature Research, 2020)
    PDA is a major cause of US cancer-related deaths. Oncogenic Kras presents in 90% of human PDAs. Kras mutations occur early in pre-neoplastic lesions but are insufficient to cause PDA. Other contributing factors early in ...
  • Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer 

    Saatçi, Ö.; Kaymak, A.; Raza, Umar; Ersan, Pelin G.; Akbulut, Özge; Banister, C. E.; Sikirzhytski, V.; Tokat, Ünal Metin; Aykut, Gamze; Ansari, Suhail A.; Tatlı-Doğan, H.; Doğan, M.; Jandaghi, P.; Işık, A.; Gündoğdu, F.; Kösemehmetoğlu, K.; Dizdar, Ö.; Aksoy, S.; Akyol, A.; Üner, A.; Buckhaults, P. J.; Riazalhosseini, Y.; Şahin, Özgür (Nature Research, 2020)
    Chemoresistance is a major obstacle in triple negative breast cancer (TNBC), the most aggressive breast cancer subtype. Here we identify hypoxia-induced ECM re-modeler, lysyl oxidase (LOX) as a key inducer of chemoresistance ...

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