Recent Submissions

  • From your nose to your toes: a review of severe acute respiratory syndrome coronavirus 2 pandemic‒associated pernio 

    Arkin, L. M.; Moon, J. J.; Tran, J. M.; Asgari, S.; O'Farrelly, C.; Casanova, J. -L.; Cowen, E. W.; Mays, J. W.; Singh, A. M.; Drolet, B. A.; Aiuti, A.; Belot, A.; Bolze, A.; Bondarenko, A.; Sediva, A.; Shcherbina, A.; Planas, A. M.; Condino-Neto, A.; Pujol, A.; Catherine, B.; Flores, C.; Rodríguez-Gallego, C.; Prando, C.; Dalgard, C. L.; Roger, C.; Mansouri, D.; van, de Beek, D.; Vinh, D. C.; Hsieh, E.; Andreakos, E.; Haerynck, F.; Uddin, F.; Casari, G.; Novelli, G.; Pesole, G.; Meyts, I.; Tancevski, I.; Fellay, J.; Tur, J.; Kisand, K.; Okamoto, K.; Mironska, K.; Abel, L.; Renia, L.; Ng, L. F. P.; Shahrooei, M.; Soler-Palacín, P.; Brodin, P.; Pan-Hammarström, Q.; Halwani, R.; Perez, de Diego, R.; Al-Muhsen, S.; Espinosa-Padilla, S.; Okada, S.; Özçelik, Tayfun; Tayoun, A. A.; Karamitros, T.; Mogensen, T. H.; Lau, Y. L. (Elsevier Ltd, 2021)
    Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio ...
  • A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection 

    Andreakos, Evangelos; Abel, Laurent; Vinh, Donald C; Kaja, Elżbieta; Drolet, Beth A.; Zhang, Qian; O'Farrelly, Cliona; Novelli, Giuseppe; Rodríguez-Gallego, Carlos; Haerynck, Filomeen; Prando, Carolina; Pujol, Aurora; Su, Helen C.; Casanova, Jean-Laurent; Spaan, András N; Bastard, Paul; Biggs, Catherine M; Bigio, Benedetta; Boisson, Bertrand; Bolze, Alexandre; Bondarenko, Anastasiia; Brodin, Petter; Chakravorty, Samya; Christodoulou, John; Cobat, Aurelié; Condino-Neto, Antonio; Constantinescu, Stefan N; Feldman, Hagit Baris; Fellay, Jacques; Flores, Carlos; Halwani, Rabih; Jouanguy, Emmanuelle; Lau, Yu-Lung; Meyts, Isabelle; Mogensen, Trine H; Okada, Satoshi; Okamoto, Keisuke; Özçelik, Tayfun; Pan-Hammarström, Qiang; Diego, Rebeca Pérez de; Planas, Anna M; Puel, Anne; Quintana-Murci, Lluis; Renia, Laurent; Resnick, Igor; Sediva, Anna; Shcherbina, Anna; Slaby, Ondrej; Tancevski, Ivan; Turvey, Stuart E; Uddin, K M Furkan; Beek, Diederik van de; Zatz, Mayana; Zawadzki, Pawel (Springer Nature, 2021-10-18)
    SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account ...
  • SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease? 

    Sancho-Shimizu, V.; Brodin, P.; Cobat, A.; Biggs, C. M.; Toubiana, J.; Lucas, C. L.; Henrickson, S. E.; Belot, A.; MIS-C@CHGE; Tangye, S. G.; D. Milner, J.; Levin, M.; Abel, L.; Bogunovic, D.; Casanova, J.-L.; Zhang, S. -Y.; Özçelik, Tayfun (Rockefeller University Press, 2021)
    Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood ...
  • Discovery of cancer-specific and independent prognostic gene subsets of the slit-robo family using TCGA-PANCAN datasets 

    Özhan, Ayşe; Tombaz, Melike; Konu, Özlen (Mary Ann Liebert, 2021-12-08)
    The Slit-Robo family of axon guidance molecules works in concert, playing important roles in organ devel opment and cancer. Expressions of individual Slit-Robo genes have been used in calculating univariable hazard ratios ...
  • Transcriptome profiles associated with selenium-deficiency-dependent oxidative stress identify potential diagnostic and therapeutic targets in liver cancer cells 

    Gözen, D.; Kahraman, D. C.; Narcı, K.; Shehwana, H.; Konu, Özlen; Çetin-Atalay, Rengül (Scientific and Technical Research Council of Turkey - TUBITAK,Turkiye Bilimsel ve Teknik Arastirma Kurumu, 2021-04-20)
    Hepatocellular carcinoma (HCC) is one of the most common cancer types with high mortality rates and displays increased resistance to various stress conditions such as oxidative stress. Conventional therapies have low ...
  • Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET] 

    Fernandez-Checa, J. C.; Bagnaninchi, P.; Ye, H.; Sancho-Bru, P.; Falcon-Perez, J. M.; Royo, F.; Garcia-Ruiz, C.; Konu, Özlen; Miranda, J.; Lunov, O.; Dejneka, A.; Elfick, A.; McDonald, A.; Sullivan, G. J.; Aithal, G. P.; Lucena, M. I.; Andrade, R. J.; Fromenty, B.; Kranendonk, M.; Cubero, F. J.; Nelson, L. J. (Elsevier, 2021-06-24)
    Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF) and one of the leading indications for liver transplantation in Western societies. Given the wide use of both prescribed and over the counter ...
  • Short-term dietary restriction maintains synaptic plasticity whereas short-term overfeeding alters cellular dynamics in the aged brain: evidence from the zebrafish model organism 

    Karoğlu-Eravşar, Elif Tuğçe; Tüz Şaşik, Melek Umay; Adams, Michelle (Elsevier, 2021-06-19)
    Increased caloric intake (OF) impairs quality of life causing comorbidities with other diseases and cognitive deficits, whereas dietary restriction (DR) increases healthspan by preventing age-related deteriorations. To ...
  • The optomotor response of aging zebrafish reveals a complex relationship between visual motion characteristics and cholinergic system 

    Karaduman, Ayşenur; Karoğlu-Eravşar, Elif Tuğçe; Kaya, Utku; Aydın, Alaz; Adams, Michelle; Kafalıgönül, Hulusi (Elsevier, 2020-10-23)
    Understanding the principles underlying age-related changes in motion perception is paramount for improving the quality of life and health of older adults. However, the mechanisms underlying age-related alterations in this ...
  • Role of autophagy and evaluation the effects of microRNAs 214, 132, 34c and prorenin receptor in a rat model of focal segmental glomerulosclerosis 

    Yildirim, D.; Bender, O.; Fırat Karagöz, Zehra; Helvacioglu, F.; Bilgic, M. A.; Akcay, A.; Ruzgaresen, N. B. (Elsevier, 2021-06-01)
    Aims Focal segmental glomerulosclerosis (FSGS) is the common cause of chronic renal disease worldwide. Although there are many etiologic factors which have common theme of podocyte injury conclusive etiology is not clearly ...
  • Epithelial-to-mesenchymal transition is not a major modulating factor in the cytotoxic response to natural products in cancer cell lines 

    Küçükkaraduman, Barş; Çiçek, Ekin Gökçe; Akbar, Muhammad Waqas; Demirkol Canlı, Seçil; Vural, Burçak; Gure, Ali Osmay (MDPI AG, 2021-09-27)
    Numerous natural products exhibit antiproliferative activity against cancer cells by modulating various biological pathways. In this study, we investigated the potential use of eight natural compounds (apigenin, curcumin, ...
  • Reconstitution of Pol II (G) responsive form of the human Mediator complex 

    Cevher, Murat Alper (Scientific and Technical Research Council of Turkey - TUBITAK,Turkiye Bilimsel ve Teknik Arastirma Kurumu, 2021-06-23)
    RNA polymerase II (Pol II) is a 12 subunit protein complex from yeast to human that is required for gene expression. Gdown1 containing Pol II [Pol II (G)] is a special form of Pol II that is catalytically inactive and ...
  • Cortical connectivity in the face of congenital structural changes—A case of homozygous LAMC3 mutation 

    Demirayak, P.; Oğuz, Kader Karlı; Üstün, Fatma Seyhun; Ürgen, Buse Merve; Topaç, Yasemin; Gilani, İrtiza; Kansu, T.; Saygı, S.; Özçelik, Tayfun; Boyacı, Hüseyin; Doerschner, Katja (John Wiley & Sons Ltd., 2021-08)
    The homozygous LAMC3 gene mutation is associated with severe bilateral smoothening and thickening of the lateral occipital cortex . Despite this and further significant changes in gray matter structure, a patient harboring ...
  • Global miRNA expression of bone marrow mesenchymal stem/stromal cells derived from Fanconi anemia patients 

    Cagnan, I.; Keles, M.; Keskus, Ayse Gokce; Tombaz, Melike; Sahan, O. B.; Aerts-Kaya, F.; Uckan-Cetinkaya, D.; Konu, Ozlen; Gunel-Ozcan, A. (Springer, 2022-01)
    Fanconi anemia (FA) is a rare genetic disorder characterized by genomic instability, developmental defects, and bone marrow (BM) failure. Hematopoietic stem cells (HSCs) in BM interact with the mesenchymal stem/stromal ...
  • Prevalence and clinical/molecular characteristics of PTEN mutations in Turkish children with autism spectrum disorders and macrocephaly 

    Kaymakçalan, H.; Kaya, İlyas; Kaya, İ.; Binici, N. C.; Nikerel, E.; Özbaran, B.; Aksoy, M. G.; Erbilen, S.; Özyurt, G.; Jahan, N.; Çelik, D.; Yarabaş, K.; Yalçınkaya, Leyla; Durak, S.; Köse, S.; Şençiçek, A. G. E. (John Wiley & Sons Ltd., 2021-07-16)
    Background Phosphatase and tensin homolog (PTEN) germline mutations are associated with cancer syndromes (PTEN hamartoma tumor syndrome; PHTS) and in pediatric patients with autism spectrum disorder (ASD) and macrocephaly. ...
  • CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer 

    Shehwana, Huma; Keskus, Ayse Gokce; Ozdemir, E. Sila; Acikgöz, Azer Aylin; Biyik-Sit, Rumeysa; Cagnan, I.; Gunes, Damla; Jahja, Ermira; Cingir-Koker, Sahika; Olmezer, Gizem; Sucularli, Ceren; Konu, Ozlen (Springer, 2021-04)
    Cholinergic signals can be important modulators of cellular signaling in cancer. We recently have shown that knockdown of nicotinic acetylcholine receptor subunit alpha 5, CHRNA5, diminishes the proliferative potential of ...
  • Development and preclinical evaluation of virus-like particle vaccine against COVID-19 infection 

    Yılmaz, İsmail Cem; İpekoğlu, E. M.; Bülbül, Artun; Turay, Nilsu; Yıldırım, Muzaffer; Evcili, İrem; Yılmaz, N. S.; Güvençli, N.; Aydın, Y.; Güngör, Bilgi; Saraydar, Berfu; Bartan, Aslı Gülce; İbibik, Bilgehan; Bildik, Tuğçe; Baydemir, İ.; Şanlı, H. A.; Kayaoğlu, B.; Ceylan, Yasemin; Yıldırım, Tuğçe; Abraş, İrem; Ayanoğlu, C.; Cam, S. B.; Dede, E. C.; Gizer, M.; Erganis, O.; Saraç, F.; Uzar, S.; Enul, H.; Adıay, C.; Aykut, Gamze; Polat, H.; Yıldırım, İ. S.; Tekin, S.; Körüklüoğlu, G.; Zeytin, H. E.; Korkusuz, P.; Gürsel, İhsan; Gürsel, M. (Wiley-Blackwell Publishing Ltd., 2021-09-14)
    Background Vaccines that incorporate multiple SARS-CoV-2 antigens can further broaden the breadth of virus-specific cellular and humoral immunity. This study describes the development and immunogenicity of SARS-CoV-2 VLP ...
  • CoVrimer: a tool for aligning SARS-CoV-2 primer sequences and selection of conserved/degenerate primers 

    Vural-Özdeniz, Merve; Aktürk, Aslınur; Demirdizen, Mert; Leka, Ronaldo; Acar, Rana; Konu, Özlen (Academic Press, 2021-07-20)
    As mutations in SARS-CoV-2 virus accumulate rapidly, novel primers that amplify this virus sensitively and specifically are in demand. We have developed a webserver named CoVrimer by which users can search for and align ...
  • Ecto-5′-Nucleotidase (CD73) regulates the survival of CD8+ T cells 

    Rosemblatt, M. V.; Parra-Tello, B.; Briceño, P.; Rivas-Yáñez, E.; Tucer, Suat; Saavedra-Almarza, J.; Hörmann, P.; Martínez, B. A.; Lladser, A.; Rosemblatt, M.; Çekiç, Çağlar; Bono, M. R.; Sauma, D. (Frontiers Media S.A., 2021-04-13)
    Ecto-5′-nucleotidase (CD73) is an enzyme present on the surface of tumor cells whose primary described function is the production of extracellular adenosine. Due to the immunosuppressive properties of adenosine, CD73 is ...
  • DOT1L complex regulates transcriptional initiation in human erythroleukemic cells 

    Wu, A.; Zhi, J.; Tian, T.; Cihan, A.; Cevher, Murat Alper; Liu, Z.; David, Y.; Muir, T. W.; Roeder, R. G.; Yu, M. (National Academy of Sciences, 2021-06-29)
    DOT1L, the only H3K79 methyltransferase in human cells and a homolog of the yeast Dot1, normally forms a complex with AF10, AF17, and ENL or AF9, is dysregulated in most cases of mixed-lineage leukemia (MLLr), and has been ...
  • The genetic structure of the Turkish population reveals high levels of variation and admixture 

    Kars, Meltem Ece; Başak, A. N.; Onat, Onur Emre; Bilguvar, K.; Choi, J.; Itan, Y.; Çağlar, C.; Palvadeau, R.; Casanova, J.-L.; Cooper, D. N.; Stenson, P. D.; Yavuz, A.; Buluş, H.; Günel, M.; Friedman, J. M.; Özçelik, Tayfun (National Academy of Sciences, 2020-12-18)
    The construction of population-based variomes has contributed substantially to our understanding of the genetic basis of human inherited disease. Here, we investigated the genetic structure of Turkey from 3,362 unrelated ...

View more