Recent Submissions

  • Oncogenic kinase-induced PKM2 tyrosine 105 phosphorylation converts nononcogenic PKM2 to a tumor promoter and induces cancer stem-like cells 

    Zhou, Z.; Li, M.; Zhang, L.; Zhao, H.; Sahin, Ö.; Chen, J.; Zhao, J. J.; Songyang, Z.; Yu, D. (American Association for Cancer Research, 2018)
    The role of pyruvate kinase M2 isoform (PKM2) in tumor progression has been controversial. Previous studies showed that PKM2 promoted tumor growth in xenograft models; however, depletion of PKM2 in the Brca1-loss–driven ...
  • Early detection and staging of colorectal cancer using a panel of micro RNAs 

    Shapira, R.; Ilyayev, N.; Attali, R.; Westrich, G.; Halle, D.; Speter, C.; Stavropoulos, A. V.; Roistacher, M.; Pavlov, V.; Grinbaum, R.; Protic, P.; Gure, A. O.; Bilchik, A. J.; Stojadinovic, A.; Mitrani-Rosenbaum, S.; Nissan, A. (OMICS, 2018)
    Purpose: To improve lymph node (LN) staging in patients with colon cancer (CC). The present study describes the selection of CC-specific miRNAs and assesses their utility as a micro metastases detection assay. Methods: ...
  • PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors 

    Cagnan, I.; Cosgun, E.; Konu, O.; Uckan, D.; Gunel-Ozcan, A. (Springer Netherlands, 2018)
    HOX and TALE transcription factors are important regulators of development and homeostasis in determining cellular identity. Deregulation of this process may drive cancer progression. The aim of this study was to investigate ...
  • Abnormal subcortical activity in congenital mirror movement disorder with RAD51 mutation 

    Demirayak, P.; Onat, O. E.; Gevrekci, A. Ö.; Gülsüner, S.; Uysal, H.; Bilgen, R.; Doerschner, K.; Özçelik, T.; Boyacı, H. (Turkish Society of Radiology, 2018)
    PURPOSE Congenital mirror movement disorder (CMMD) is characterized by unintended, nonsuppressible, homologous mirroring activity contralateral to the movement on the intended side of the body. In healthy controls, unilateral ...
  • IKBKE inhibits TSC1 to activate the mTOR/S6K pathway for oncogenic transformation 

    Göktuna, S. İ. (Scientific and Technical Research Council of Turkey - TUBITAK,Turkiye Bilimsel ve Teknik Arastirma Kurumu, 2018)
    IKBKE (IKKε) has emerged as a key modulator of multiple substrates, controlling oncogenic pathways in various malignancies. mTOR signaling, required for cellular growth, proliferation, and vascular angiogenesis in cancer, ...
  • SIK2 attenuates proliferation and survival of breast cancer cells with simultaneous perturbation of MAPK and PI3K/Akt pathways 

    Zohrap, N.; Saatci, Ö.; Ozes, B.; Coban, I.; Atay, H. M.; Battaloglu, E.; Şahin, Ö.; Bugra, K. (Impact Journals LLC, 2018)
    Salt Inducible Kinase2 (SIK2) has been shown to contribute to tumorigenesis in multiple tumor types in a dichotomous manner. However, little is known about its contribution to breast malignancies. Here, we report SIK2 as ...
  • Cholinergic receptor nicotinic alpha 5 (CHRNA5) RNAi is associated with cell cycle inhibition, apoptosis, DNA damage response and drug sensitivity in Breast cancer 

    Koker, S. C.; Jahja, E.; Shehwana, H.; Keskus, A. G.; Konu, O. (Public Library of Science, 2018)
    Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is an important susceptibility locus for nicotine addiction and lung cancer. Depletion of CHRNA5 has been associated with reduced cell viability, increased apoptosis and ...
  • Discovering lncRNA mediated sponge interactions in breast cancer molecular subtypes 

    Olgun, G.; Sahin, O.; Tastan, O. (BioMed Central, 2018)
    Background: Long non-coding RNAs (lncRNAs) can indirectly regulate mRNAs expression levels by sequestering microRNAs (miRNAs), and act as competing endogenous RNAs (ceRNAs) or as sponges. Previous studies identified ...
  • A case report of syndromic multinodular goitre in adolescence: Exploring the phenotype overlap between cowden and DICER1 syndromes 

    Soglio, D. B.; Kock, L.; Gauci, R.; Sabbaghian, N.; Thomas, E.; Atkinson, H. C.; Pachter, N.; Ryan, S.; Walsh, J. P.; Kumarasinghe, M. P.; Carpenter, K.; Aydoğan, A.; Stewart, C. J. R.; Foulkes, W. D.; Choong, C. S. (S. Karger AG, 2018)
    Background: Hereditary tumour predisposition syndromes may increase the risk for development of thyroid nodules at a young age. We present the case of an adolescent female with Cowden syndrome who had some atypical phenotypic ...
  • Polyol pathway links glucose metabolism to the aggressiveness of cancer cells 

    Schwab, A.; Siddiqui, A.; Vazakidou, M. E.; Napoli, F.; Bottcher, M.; Menchicchi, B.; Raza, U.; Saatci, O.; Krebs, A. M.; Ferrazzi, F.; Rapa, I.; Wilde, K. D.; Waldner, M. J.; Ekici, A. B.; Rasheed, S. A. K.; Mougiakakos, D.; Oefner, P. J.; Sahin, O.; Volante, M.; Greten, F. R.; Brabletz, T.; Ceppi, P. (American Association for Cancer Research, 2018)
    Cancer cells alter their metabolism to support their malignant properties. In this study, we report that the glucose-transforming polyol pathway (PP) gene aldo-keto-reductase-1-member-B1 (AKR1B1) strongly correlates with ...
  • Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant 

    Boisson-Dupuis, S.; Ramirez-Alejo, N.; Li, Z.; Patin, E.; Rao, G.; Kerner, G.; Lim, C. K.; Krementsov, D. N.; Hernandez, N.; Ma, C. S.; Zhang, Q.; Markle, J.; Martinez-Barricarte, R.; Payne, K.; Fisch, R.; Deswarte, C.; Halpern, J.; Bouaziz, M.; Mulwa, J.; Sivanesan, D.; Lazarov, T.; Naves, R.; Garcia, P.; Itan, Y.; Boisson, B.; Checchi, A.; Jabot-Hanin, F.; Cobat, A.; Guennoun, A.; Jackson, C. C.; Pekcan, S.; Caliskaner, Z.; Inostroza, J.; Costa-Carvalho, B. T.; de, Albuquerque, J. A. T.; Garcia-Ortiz, H.; Orozco, L.; Ozcelik, T.; Abid, A.; Rhorfi, I. A.; Souhi, H.; Amrani, H. N.; Zegmout, A.; Geissmann, F.; Michnick, S. W.; Muller-Fleckenstein, I.; Fleckenstein, B.; Puel, A.; Ciancanelli, M. J.; Marr, N.; Abolhassani, H.; Balcells, M. E.; Condino-Neto, A.; Strickler, A.; Abarca, K.; Teuscher, C.; Ochs, H. D.; Reisli, I.; Sayar, E. H.; El-Baghdadi, J.; Bustamante, J.; Hammarström, L.; Tangye, S. G.; Pellegrini, S.; Quintana-Murci, L.; Abel, L.; Casanova, J. -L. (NLM (Medline), 2018)
    Inherited IL-12Rβ1 and TYK2 deficiencies impair both IL-12- and IL-23-dependent IFN-γ immunity and are rare monogenic causes of tuberculosis, each found in less than 1/600,000 individuals. We show that homozygosity for the ...
  • IKKs and tumor cell plasticity 

    Göktuna, S. I.; Diamanti, M. A.; Chau, T. L. (Wiley-Blackwell Publishing Ltd., 2018)
    Nuclear factor κB (NF-κB) transcription factors are the central hubs of signaling pathways connecting proinflammatory signals to cell survival, proliferation and cytokine production. In cancers, NF-κB signaling influences ...
  • Modules of correlated genes in a gene expression regulatory network of CDDP-resistant cancer cells 

    Vargas, D. J.; Acón, M. S.; Sahin, Ö.; Eyüpoğlu, E.; Riazalhosseini, Y.; Mora, J. M.; Coto, J. G.; Rodriguez, R. M. (Institute of Electrical and Electronics Engineers, 2018)
    Chemotherapeutic drugs have been used as important strategies in cancer treatment. However, chemotherapy-resistant tumors arise especially in relapsing and progressive disease. Understanding of mechanisms underlaying ...
  • Heterodoped manoparticles as dual-mode contrast agent for MRI 

    Alipour, A.; Sharma, V. K.; Soran-Erdem, Z.; Kelestemur, Y.; Aykut, Z. G.; Demir, H. V. (Institute of Electrical and Electronics Engineers, 2018)
    The purpose of this work is to synthesize Mn-Fe heterodoped ZnSe tetrapod nanocrystals (NCs) as dualmode MRI contrast agent to offer synergetic beneficial over the single contrast tracer. Also, in vivo feasibility of the ...
  • Contrast enhancement of microscopy images using image phase information 

    Cakir, S.; Kahraman, D. C.; Cetin-Atalay, R.; Cetin, A. E. (Institute of Electrical and Electronics Engineers, 2018)
    Contrast enhancement is an important preprocessing step for the analysis of microscopy images. The main aim of contrast enhancement techniques is to increase the visibility of the cell structures and organelles by modifying ...
  • Development of a novel zebrafish xenograft model in ache mutants using liver cancer cell lines 

    Avci, M. E.; Keskus, A. G.; Targen, S.; Isilak, M. E.; Ozturk, M.; Atalay, R. C.; Adams, M. M.; Konu, O. (Nature Publishing Group, 2018)
    Acetylcholinesterase (AChE), an enzyme responsible for degradation of acetylcholine, has been identified as a prognostic marker in liver cancer. Although in vivo Ache tumorigenicity assays in mouse are present, no established ...
  • Regulation of macrophage immunometabolism in atherosclerosis 

    Koelwyn, G. J.; Corr, E. M.; Erbay, E.; Moore, K. J. (Nature Publishing Group, 2018)
    After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as discrete epigenetic changes, that can dictate both ongoing and future inflammatory responses. In atherosclerosis, in which ...
  • Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer 

    Saatci, Ö.; Borgoni, S.; Akbulut, Ö.; Durmuş, S.; Raza, U.; Eyüpoğlu, E.; Alkan, C.; Akyol, A.; Kütük, Ö.; Wiemann, S.; Şahin, Ö. (Nature Publishing Group, 2018)
    Trastuzumab-refractory, HER2 (human epidermal growth factor receptor 2)-positive breast cancer is commonly treated with trastuzumab emtansine (T-DM1), an antibody-drug conjugate of trastuzumab and the microtubule-targeting ...
  • Autonomous synthesis of fluorescent silica biodots using engineered fusion proteins 

    Olmez, T. T.; Yuca, E.; Eyupoglu, E.; Catalak, H. B.; Sahin, O.; Seker, U. O. S. (American Chemical Society, 2018)
    Formation of biological materials is a well-controlled process that is orchestrated by biomolecules such as proteins. Proteins can control the nucleation and mineralization of biomaterials, thereby forming the hard tissues ...
  • A temperature sensor implant for active implantable medical devices for in vivo subacute heating tests under MRI 

    Silemek, B.; Acikel, V.; Oto, C.; Alipour, A.; Aykut, Z. G.; Algin, O.; Atalar, E. (John Wiley and Sons, 2018)
    Purpose: To introduce a temperature sensor implant (TSI) that mimics an active implantable medical device (AIMD) for animal testing of MRI heating. Computer simulations and phantom experiments poorly represent potential ...

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