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A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains
(John Wiley & Sons, Inc., 2018)
This large multi‐center study investigates the relationships between genetic risk for schizophrenia and bipolar disorder, and multi‐modal endophenotypes for psychosis. The sample included 4,242 individuals; 1,087 patients ...
Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders
Background There is increasing evidence for shared genetic susceptibility between schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases in risk individually, their combination into a ...
Associations between psychosis endophenotypes across brain functional, structural, and cognitive domains
(Cambridge University Press, 2018)
Background A range of endophenotypes characterise psychosis, however there has been limited work understanding if and how they are inter-related.Methods This multi-centre study includes 8754 participants: 2212 people with ...
The impact of psychosis genome-wide associated ZNF804A variation on verbal fluency connectivity
Schizophrenia (SCZ) and bipolar disorder (BD) have high heritability. Genome-wide association studies (GWAS) have identified ZNF804A as a significant risk gene for both illnesses. A validation of this finding at the brain ...