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Schizophrenia polygenic risk score influence on white matter microstructure
Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide ...
Intelligence, educational attainment, and brain structure in those at familial high‐risk for schizophrenia or bipolar disorder
First‐degree relatives of patients diagnosed with schizophrenia (SZ‐FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First‐degree relatives of ...
Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study
(Springer Nature, 2020)
The burden of large and rare copy number genetic variants (CNVs) as well as certain specific CNVs increase the risk of developing schizophrenia. Several cognitive measures are purported schizophrenia endophenotypes and may ...