Release and antibacterial activity of allyl isothiocyanate/-cyclodextrin complex encapsulated in electrospun nanofibers
Dogan, S. Y.
Colloids and Surfaces B: Biointerfaces
Aytac, Z., Dogan, S. Y., Tekinay, T., & Uyar, T. (2014). Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers. Colloids and Surfaces B: Biointerfaces, 120, 125-131.
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/13127
Allyl isothiocyanate (AITC) is known as an efficient antibacterial agent but it has a very high volatility. Herein, AITC and AITC/-cyclodextrin (CD)-inclusion complex (IC) incorporated in polyvinyl alcohol (PVA) nanofibers were produced via electrospinning. SEM images elucidated that incorporation of AITC and AITC/-CD-IC into polymer matrix did not affect the bead-free fiber morphology of PVA nanofibers. 1H-NMR and headspace GC-MS analyses revealed that very low amount of AITC was remained in PVA/AITC-NF because of the rapid evaporation of AITC during the electrospinning process. Nevertheless, much higher amount of AITC was preserved in the PVA/AITC/-CD-IC-NF due to the CD inclusion complexation. The sustained release of AITC from nanofibers was evaluated at 30 ◦C, 50 ◦C and 75 ◦C via headspace GC–MS. When compared to PVA/AITC-NF, PVA/AITC/-CD-IC-NF has shown higher antibacterial activity against Escherichia coli and Staphylococcus aureus due to the presence of higher amount of AITC in this sample which was preserved by CD-IC. ©