Semi-automatic segmentation of subcutaneous tumours from micro-computed tomography images
Gunduz Demir, C.
Graves, E. E.
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/12952
Physics in Medicine and Biology
Institute of Physics
This paper outlines the first attempt to segment the boundary of preclinical subcutaneous tumours, which are frequently used in cancer research, from micro-computed tomography (microCT) image data. MicroCT images provide low tissue contrast, and the tumour-to-muscle interface is hard to determine, however faint features exist which enable the boundary to be located. These are used as the basis of our semi-automatic segmentation algorithm. Local phase feature detection is used to highlight the faint boundary features, and a level set-based active contour is used to generate smooth contours that fit the sparse boundary features. The algorithm is validated against manually drawn contours and micro-positron emission tomography (microPET) images. When compared against manual expert segmentations, it was consistently able to segment at least 70% of the tumour region (n = 39) in both easy and difficult cases, and over a broad range of tumour volumes. When compared against tumour microPET data, it was able to capture over 80% of the functional microPET volume. Based on these results, we demonstrate the feasibility of subcutaneous tumour segmentation from microCT image data without the assistance of exogenous contrast agents. Our approach is a proof-of-concept that can be used as the foundation for further research, and to facilitate this, the code is open-source and available from www.setuvo.com. © 2013 Institute of Physics and Engineering in Medicine.
Ali, R., Gunduz-Demir, C., Szilágyi, T., Durkee, B., & Graves, E. E. (2013). Semi-automatic segmentation of subcutaneous tumours from micro-computed tomography images. Physics in medicine and biology, 58(22), 8007.
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