Design of a Gd-DOTA-Phthalocyanine Conjugate Combining MRI Contrast Imaging and Photosensitization Properties as a Potential Molecular Theranostic
Tekdas, D. A.
Tekinay, A. B.
Chernonosov, A. A.
Guler, M. O.
Gurek, A. G.
Journal of Photochemistry and Photobiology A: Chemistry
Aydın Tekdaş, D., Garifullin, R., Şentürk, B., Zorlu, Y., Gundogdu, U., Atalar, E., ... & Guler, M. O. (2014). Design of a Gd‐DOTA‐Phthalocyanine Conjugate Combining MRI Contrast Imaging and Photosensitization Properties as a Potential Molecular Theranostic. Photochemistry and photobiology, 90(6), 1376-1386.
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/12769
The design and synthesis of a phthalocyanine - Gd-DOTA conjugate is presented to open the way to novel molecular theranostics, combining the properties of MRI contrast imaging with photodynamic therapy. The rational design of the conjugate integrates isomeric purity of the phthalocyanine core substitution, suitable biocompatibility with the use of polyoxo water-solubilizing substituents, and a convergent synthetic strategy ended by the use of click chemistry to graft the Gd-DOTA moiety to the phthalocyanine. Photophysical and photochemical properties, contrast imaging experiments and preliminary in vitro investigations proved that such a combination is relevant and lead to a new type of potential theranostic agent. © 2014 The American Society of Photobiology.