Near-IR Absorbing BODIPY Derivates as Glutathione-Activated Photosensitizers for Selective Photodynamic Action
Turan, I. S.
Cakmak, F. P.
Yildirim, D. C.
Cetin Atalay, R.
Akkaya, E. U.
Chemistry - A European Journal
Turan, I. S., Cakmak, F. P., Yildirim, D. C., Cetin‐Atalay, R., & Akkaya, E. U. (2014). Near‐IR Absorbing BODIPY Derivatives as Glutathione‐Activated Photosensitizers for Selective Photodynamic Action. Chemistry–A European Journal, 20(49), 16088-16092.
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/12596
Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high intracellular glutathione concentrations within cancer cells, a series of BODIPY-based sensitizers that can generate cytotoxic singlet oxygen only after glutathione-mediated cleavage of the electron-sink module were designed and synthesized. Cell culture studies not only validate our design, but also suggest an additional role for the relatively hydrophobic quencher module in the internalization of the photosensitizer.
- Department of Chemistry