• About
  • Policies
  • What is openaccess
  • Library
  • Contact
Advanced search
      View Item 
      •   BUIR Home
      • Scholarly Publications
      • Faculty of Science
      • Department of Physics
      • View Item
      •   BUIR Home
      • Scholarly Publications
      • Faculty of Science
      • Department of Physics
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging

      Thumbnail
      View / Download
      698.3 Kb
      Author
      Sharma, V. K.
      Gokyar, S.
      Kelestemur, Y.
      Erdem, T.
      Unal, E.
      Demir, Hilmi Volkan
      Date
      2014
      Source Title
      Small
      Print ISSN
      1613-6810
      Electronic ISSN
      1613-6829
      Publisher
      Wiley-VCH Verlag
      Volume
      10
      Issue
      23
      Pages
      4961 - 4966
      Language
      English
      Type
      Article
      Item Usage Stats
      151
      views
      163
      downloads
      Abstract
      In this work, dual-modal (fluorescence and magnetic resonance) imaging capabilities of water-soluble, low-toxicity, monodisperse Mn-doped ZnSe nanocrystals (NCs) with a size (6.5 nm) below the optimum kidney cutoff limit (10 nm) are reported. Synthesizing Mn-doped ZnSe NCs with varying Mn2+ concentrations, a systematic investigation of the optical properties of these NCs by using photoluminescence (PL) and time resolved fluorescence are demonstrated. The elemental properties of these NCs using X-ray photoelectron spectroscopy and inductive coupled plasma-mass spectroscopy confirming Mn2+ doping is confined to the core of these NCs are also presented. It is observed that with increasing Mn2+ concentration the PL intensity first increases, reaching a maximum at Mn2+ concentration of 3.2 at% (achieving a PL quantum yield (QY) of 37%), after which it starts to decrease. Here, this high-efficiency sample is demonstrated for applications in dual-modal imaging. These NCs are further made water-soluble by ligand exchange using 3-mercaptopropionic acid, preserving their PL QY as high as 18%. At the same time, these NCs exhibit high relaxivity (≈2.95 mM-1 s-1) to obtain MR contrast at 25°C, 3 T. Therefore, the Mn2+ doping in these water-soluble Cd-free NCs are sufficient to produce contrast for both fluorescence and magnetic resonance imaging techniques.
      Keywords
      Fluorescence Imaging
      Low-toxicity
      Magnetic Resonance Imaging
      Nanocrystals
      Water-solubility
      Permalink
      http://hdl.handle.net/11693/12486
      Published Version (Please cite this version)
      http://dx.doi.org/10.1002/smll.201401143
      Collections
      • Department of Electrical and Electronics Engineering 3624
      • Department of Physics 2364
      • Institute of Materials Science and Nanotechnology (UNAM) 1873
      Show full item record

      Browse

      All of BUIRCommunities & CollectionsTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsThis CollectionTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartments

      My Account

      Login

      Statistics

      View Usage StatisticsView Google Analytics Statistics

      Bilkent University

      If you have trouble accessing this page and need to request an alternate format, contact the site administrator. Phone: (312) 290 1771
      © Bilkent University - Library IT

      Contact Us | Send Feedback | Off-Campus Access | Admin | Privacy