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dc.contributor.authorUzunalli, G.en_US
dc.contributor.authorSoran, Z.en_US
dc.contributor.authorErkal, T. S.en_US
dc.contributor.authorDagdas, Y. S.en_US
dc.contributor.authorDinc, E.en_US
dc.contributor.authorHondur, A. M.en_US
dc.contributor.authorBilgihan, K.en_US
dc.contributor.authorAydin, B.en_US
dc.contributor.authorGuler, M. O.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.date.accessioned2015/07/28en_US
dc.date.accessioned2015-07-28T11:58:39Z
dc.date.available2015-07-28T11:58:39Z
dc.date.issued2014-12-12en_US
dc.identifier.citationUzunalli, G., Soran, Z., Erkal, T. S., Dagdas, Y. S., Dinc, E., Hondur, A. M., ... & Tekinay, A. B. (2014). Bioactive self-assembled peptide nanofibers for corneal stroma. Acta Biomaterialia, 10, 1156-1166.en_US
dc.identifier.issn1742-7061en_US
dc.identifier.urihttp://hdl.handle.net/11693/11753
dc.descriptionCataloged from PDF version of article.en_US
dc.description.abstractDefects in the corneal stroma caused by trauma or diseases such as macular corneal dystrophy and keratoconus can be detrimental for vision. Development of therapeutic methods to enhance corneal regeneration is essential for treatment of these defects. This paper describes a bioactive peptide nanofiber scaffold system for corneal tissue regeneration. These nanofibers are formed by self-assembling peptide amphiphile molecules containing laminin and fibronectin inspired sequences. Human corneal keratocyte cells cultured on laminin-mimetic peptide nanofibers retained their characteristic morphology, and their proliferation was enhanced compared with cells cultured on fibronectin-mimetic nanofibers. When these nanofibers were used for damaged rabbit corneas, laminin-mimetic peptide nanofibers increased keratocyte migration and supported stroma regeneration. These results suggest that laminin-mimetic peptide nanofibers provide a promising injectable, synthetic scaffold system for cornea stroma regeneration.en_US
dc.language.isoEnglishen_US
dc.source.titleActa Biomaterialiaen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.actbio.2013.12.002en_US
dc.rightsCopyright © 2013 Elsevier Ltd.en_US
dc.subjectCorneal stroma regeneration, peptide amphiphile, RGD, self-assembly, YIGSRen_US
dc.titleBioactive self-assembled peptide nanofibers for corneal stromaen_US
dc.typeArticleen_US
dc.departmentInstitute of Materials Science and Nanotechnologyen_US
dc.citation.spage1156en_US
dc.citation.epage1166en_US
dc.citation.volumeNumber10en_US
dc.citation.issueNumber3en_US
dc.instituteInstitute of Materials Science and Nanotechnologyen_US
dc.identifier.doi10.1016/j.actbio.2013.12.002en_US
dc.publisherElsevieren_US


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