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      Bimodal interventional instrument markers for magnetic particle imaging and magnetic resonance imaging—a proof-of-concept study

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      Author(s)
      Wegner, Franz
      Lüdtke-Buzug, Kerstin
      Cremers, Sjef
      Friedrich, Thomas
      Sieren, Malte M.
      Haegele, Julian
      Koch, Martin A.
      Borm, Paul
      Buzug, Thorsten M.
      Barkhausen, Joerg
      Ahlborg, Mandy
      Sarıtaş, Emine Ülkü
      Date
      2022-05-02
      Source Title
      Nanomaterials
      Print ISSN
      20794991
      Publisher
      MDPI
      Volume
      12
      Issue
      10
      Pages
      1 - 11
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      The purpose of this work was to develop instrument markers that are visible in both magnetic particle imaging (MPI) and magnetic resonance imaging (MRI). The instrument markers were based on two different magnetic nanoparticle types (synthesized in-house KLB and commercial Bayoxide E8706). Coatings containing one of both particle types were fabricated and measured with a magnetic particle spectrometer (MPS) to estimate their MPI performance. Coatings based on both particle types were then applied on a segment of a nonmetallic guidewire. Imaging experiments were conducted using a commercial, preclinical MPI scanner and a preclinical 1 tesla MRI system. MPI image reconstruction was performed based on system matrices measured with dried KLB and Bayoxide E8706 coatings. The bimodal markers were clearly visible in both methods. They caused circular signal voids in MRI and areas of high signal intensity in MPI. Both the signal voids as well as the areas of high signal intensity were larger than the real marker size. Images that were reconstructed with a Bayoxide E8706 system matrix did not show sufficient MPI signal. Instrument markers with bimodal visibility are essential for the perspective of monitoring cardiovascular interventions with MPI/MRI hybrid systems. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
      Keywords
      Endovascular Interventions
      Hybrid Imaging
      Interventional Devices
      Magnetic Particle Imaging
      Magnetic Resonance Imaging
      Nanoparticles
      Permalink
      http://hdl.handle.net/11693/112028
      Published Version (Please cite this version)
      https://dx.doi.org/10.3390/nano12101758
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