Now showing items 1-5 of 5

    • The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity 

      Sag, D.; Cekic, C.; Wu, R.; Linden J.; Hedrick, C.C. (Nature Publishing Group, 2015)
      ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of tumour immunity. Abcg1-/- mice ...
    • Cytotoxic activities of some benzothiazole-piperazine derivatives 

      Gurdal, E.E.; Durmaz I.; Cetin-Atalay, R.; Yarim, M. (Taylor and Francis Ltd, 2015)
      Synthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and ...
    • Identification of novel neutralizing single-chain antibodies against vascular endothelial growth factor receptor 2 

      Erdag, B.; Koray Balcioglu, B.; Ozdemir Bahadir, A.; Serhatli, M.; Kacar O.; Bahar, A.; Seker, U.O.S.; Akgun, E.; Ozkan, A.; Kilic, T.; Tamerler, C.; Baysal, K. (2011)
      Human vascular endothelial growth factor (VEGF) and its receptor (VEGFR-2/kinase domain receptor [KDR]) play a crucial role in angiogenesis, which makes the VEGFR-2 signaling pathway a major target for therapeutic applications. ...
    • MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling 

      Cinar, B.; Collak F.K.; Lopez, D.; Akgul, S.; Mukhopadhyay, N.K.; Kilicarslan, M.; Gioeli, D.G.; Freeman, M.R. (2011)
      The MST1 serine - threonine kinase, a component of the RASSF1-LATS tumor suppressor network, is involved in cell proliferation and apoptosis and has been implicated in cancer. However, the physiologic role of MST1 in ...
    • Phenotype-based variation as a biomarker of sensitivity to molecularly targeted therapy in melanoma 

      Senses, K. M.; Ghasemi M.; Akbar, M. W.; Isbilen, M.; Fallacara, A. L.; Frankenburg, S.; Schenone, S.; Lotem, M.; Botta, M.; Gure, A. O. (Royal Society of Chemistry, 2017)
      Transcriptomic phenotypes defined for melanoma have been reported to correlate with sensitivity to various drugs. In this study, we aimed to define a minimal signature that could be used to distinguish melanoma sub-types ...