Now showing items 1-16 of 16

    • Biosystems engineering of prokaryotes with tumor-killing capacities 

      Kalyoncu, E.; Olmez, T. T.; Ozkan, A. D.; Sarioglu, O. F. (Bentham Science Publishers Ltd., 2016)
      Certain bacteria selectively attack tumor tissues and trigger tumor shrinkage by producing toxins and modulating the local immune system, but their clinical utility is limited because of the dangers posed by systemic ...
    • Cellular biocatalysts using synthetic genetic circuits for prolonged and durable enzymatic activity 

      Ahan, Recep Erdem; Şaltepe, Behide; Apaydın, Onur; Şeker, Urartu Özgür Şafak (Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim, 2019)
      Cellular biocatalysts hold great promise for the synthesis of difficult to achieve compounds, such as complex active molecules. Whole‐cell biocatalysts can be programmed through genetic circuits to be more efficient, but ...
    • Cellular biosensors with engineered genetic circuits 

      Saltepe, Behide; Kehribar, Ebru Şahin; Yirmibeşoǧlu, Side Selin Su; Şeker, Urartu Özgür Şafak (American Chemical Society, 2018)
      An increasing interest in building novel biological devices with designed cellular functionalities has triggered the search of innovative tools for biocomputation. Utilizing the tools of synthetic biology, numerous genetic ...
    • Combating infectious diseases with synthetic biology 

      Khan, Anooshay; Ostaku, Julian; Aras, Ebru; Safak Seker, Urartu Ozgur (American Chemical Society, 2022-01-25)
      Over the past decades, there have been numerous outbreaks, including parasitic, fungal, bacterial, and viral infections, worldwide. The rate at which infectious diseases are emerging is disproportionate to the rate of ...
    • Design and applications of self-assembled soft living materials using synthetic biology 

      Özkul, Gökçe; Yavuz, Merve; Hacıosmanoğlu, Nedim; Kırpat, Büşra Merve; Şeker, Urartu Özgür Şafak (Elsevier, 2022-01-01)
      In nature, the cells are unique biofactories of various kinds of macroscale structures. These biofactories are as old as the earth. However, as technology developed and new areas of research fields developed these cellular ...
    • Design of synthetic biological devices for detection and targeting human diseases 

      Hacıosmanoğlu, Nedim; Köse, Sıla; Ostaku, Julian; Köksaldi, İlkay Çisil; Saltepe, Behide; Şeker, Urartu Özgür Şafak (Elsevier, 2022-01-01)
      Interpreting signals coming from the surrounding environment and responding to these stimuli by adjusting physical or metabolic state is the most fundamental ability of living organisms. Repurposing these natural abilities ...
    • Engineered bacteria with genetic circuits accumulating nanomagnets as MRI contrast agents 

      Yavuz, Merve; Ütkür, Mustafa; Kehribar, Ebru Şahin; Yağız, Ecrin; Sarıtaş, Emine Ülkü; Şeker, Urartu Özgür Şafak (Wiley, 2022-01-25)
      The demand for highly efficient cancer diagnostic tools increases alongside the high cancer incidence nowadays. Moreover, there is an imperative need for novel cancer treatment therapies that lack the side effects of ...
    • Engineering of probiotic Saccharomyces boulardii as a host for living therapeutic applications 

      Kurt, Orhan Nedim (Bilkent University, 2022-09)
      Therapeutic molecules or biologically active agents used in the treatments of disorders have been manufactured employing chemical synthesis methods with high costs and limited accessibility. Even though this approach to ...
    • Genetic circuits combined with machine learning provides fast responding living sensors 

      Saltepe, Behide; Bozkurt, Eray Ulaş; Güngen, Murat Alp; Çiçek, A. Ercüment; Şeker, Urartu Özgür Şafak (Elsevier BV, 2021-04-15)
      Whole cell biosensors (WCBs) have become prominent in many fields from environmental analysis to biomedical diagnostics thanks to advanced genetic circuit design principles. Despite increasing demand on cost effective and ...
    • Genetic circuits to detect nanomaterial triggered toxicity through engineered heat shock response mechanism 

      Saltepe, Behide; Bozkurt, Eray Ulaş; Hacıosmanoğlu, Nedim; Şeker, Urartu Özgür Şafak (American Chemical Society, 2019)
      Biocompatibility assessment of nanomaterials has been of great interest due to their potential toxicity. However, conventional biocompatibility tests fall short of providing a fast toxicity report. We developed a whole ...
    • A living material platform for the biomineralization of biosilica 

      Kırpat Konak, Büşra Merve; Bakar, Mehmet Emin; Ahan, Recep Erdem; Özyürek, Emel Uzunoğlu; Dökmeci, Serap; Şafak Şeker, Urartu Özgür (Elsevier B.V., 2022-12-15)
      Nature has a vast array of biomineralization mechanisms. The commonly shared mechanism by many living organisms to form hardened tissues is the nucleation of mineral structures via proteins. Living materials, thanks to ...
    • Peptide based ligand discovery to prevent protein aggregation in neurodegenerative disease conditions 

      Beğli, Özge (Bilkent University, 2019-09)
      Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease are cognitively and physically debilitating and progressive diseases due to the gradual and irreversible loss of discrete ...
    • A recombinase-based genetic circuit for heavy metal monitoring 

      Akboğa, Doğuş; Saltepe, Behide (MDPI, 2022-02-16)
      Rapid progress in the genetic circuit design enabled whole-cell biosensors (WCBs) to become prominent in detecting an extensive range of analytes with promise in many fields, from medical diagnostics to environmental ...
    • A synthetic biology approach for nanomaterial design, synthesis and functionalization 

      Ölmez, Tolga Tarkan (Bilkent University, 2017-11)
      Biological formation of inorganic material occurs in most organisms in nature. Various biomolecules such as polypeptides, lipids and metabolites are responsible for biomineralization in cells and tissues. Biological synthesis ...
    • Synthetic genetic circuits for self-actuated cellular nanomaterial fabrication devices 

      Ölmez, Tolga Tarkan; Şahin-Kehribar, Ebru; Işılak, Musa Efe; Lu, T. K.; Şeker, Urartu Özgür Şafak (American Chemical Society, 2019)
      Genetically controlled synthetic biosystems are being developed to create nanoscale materials. These biosystems are modeled on the natural ability of living cells to synthesize materials: many organisms have dedicated ...
    • A theranostic bio-device for biomedical applications 

      Hacıosmanoğlu, Nedim (Bilkent University, 2019-08)
      Biological systems are programmable by their nature. With using the abilities of these systems, scientists have designed, engineered and repurposed living machines for various tasks including biological sensing, recording ...