Now showing items 1-8 of 8

    • Biosystems engineering of prokaryotes with tumor-killing capacities 

      Kalyoncu, E.; Olmez, T. T.; Ozkan, A. D.; Sarioglu, O. F. (Bentham Science Publishers Ltd., 2016)
      Certain bacteria selectively attack tumor tissues and trigger tumor shrinkage by producing toxins and modulating the local immune system, but their clinical utility is limited because of the dangers posed by systemic ...
    • Cellular biocatalysts using synthetic genetic circuits for prolonged and durable enzymatic activity 

      Ahan, Recep Erdem; Şaltepe, Behide; Apaydın, Onur; Şeker, Urartu Özgür Şafak (Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim, 2019)
      Cellular biocatalysts hold great promise for the synthesis of difficult to achieve compounds, such as complex active molecules. Whole‐cell biocatalysts can be programmed through genetic circuits to be more efficient, but ...
    • Cellular biosensors with engineered genetic circuits 

      Saltepe, Behide; Kehribar, Ebru Şahin; Yirmibeşoǧlu, Side Selin Su; Şeker, Urartu Özgür Şafak (American Chemical Society, 2018)
      An increasing interest in building novel biological devices with designed cellular functionalities has triggered the search of innovative tools for biocomputation. Utilizing the tools of synthetic biology, numerous genetic ...
    • Genetic circuits to detect nanomaterial triggered toxicity through engineered heat shock response mechanism 

      Saltepe, Behide; Bozkurt, Eray Ulaş; Hacıosmanoğlu, Nedim; Şeker, Urartu Özgür Şafak (American Chemical Society, 2019)
      Biocompatibility assessment of nanomaterials has been of great interest due to their potential toxicity. However, conventional biocompatibility tests fall short of providing a fast toxicity report. We developed a whole ...
    • Peptide based ligand discovery to prevent protein aggregation in neurodegenerative disease conditions 

      Beğli, Özge (Bilkent University, 2019-09)
      Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease are cognitively and physically debilitating and progressive diseases due to the gradual and irreversible loss of discrete ...
    • A synthetic biology approach for nanomaterial design, synthesis and functionalization 

      Ölmez, Tolga Tarkan (Bilkent University, 2017-11)
      Biological formation of inorganic material occurs in most organisms in nature. Various biomolecules such as polypeptides, lipids and metabolites are responsible for biomineralization in cells and tissues. Biological synthesis ...
    • Synthetic genetic circuits for self-actuated cellular nanomaterial fabrication devices 

      Ölmez, Tolga Tarkan; Şahin-Kehribar, Ebru; Işılak, Musa Efe; Lu, T. K.; Şeker, Urartu Özgür Şafak (American Chemical Society, 2019)
      Genetically controlled synthetic biosystems are being developed to create nanoscale materials. These biosystems are modeled on the natural ability of living cells to synthesize materials: many organisms have dedicated ...
    • A theranostic bio-device for biomedical applications 

      Hacıosmanoğlu, Nedim (Bilkent University, 2019-08)
      Biological systems are programmable by their nature. With using the abilities of these systems, scientists have designed, engineered and repurposed living machines for various tasks including biological sensing, recording ...