Now showing items 1-8 of 8

    • Aging alters the molecular dynamics of synapses in a sexually dimorphic pattern in zebrafish (Danio rerio) 

      Karoglu, E. T.; Halim, D. O.; Erkaya, B.; Altaytas, F.; Arslan-Ergul, A.; Konu, O.; Adams, M. M. (Elsevier, 2017-06)
      The zebrafish has become a popular model for studying normal brain aging due to its large fecundity, conserved genome, and available genetic tools; but little data exists about neurobiological age-related alterations. The ...
    • Algorithms for effective querying of compound graph-based pathway databases 

      Dogrusoz, U.; Cetintas, A.; Demir, E.; Babur, O. (BioMed Central Ltd., 2009)
      Background: Graph-based pathway ontologies and databases are widely used to represent data about cellular processes. This representation makes it possible to programmatically integrate cellular networks and to investigate ...
    • Discovering modulators of gene expression 

      Babur, Ö.; Demir, E.; Gönen, M.; Sander, C.; Dogrusoz, U. (Oxford University Press, 2010)
      Proteins that modulate the activity of transcription factors, often called modulators, play a critical role in creating tissue- and context-specific gene expression responses to the signals cells receive. GEM (Gene Expression ...
    • Identification of relative protein bands in polyacrylamide gel electrophoresis (PAGE) using a multi-resolution snake algorithm 

      Gürcan, M. N.; Koyutürk, M.; Yildiz, H. S.; Çetin-Atalay R.; Çetin, A. E. (Informa Healthcare, 1999-06)
      In polyacrylamide gel electrophoresis (PAGE) image analysis, it is important to determine the percentage of the protein of interest of a protein mixture. This study presents reliable computer software to determine this ...
    • Laminin mimetic peptide nanofibers regenerate acute muscle defect 

      Cimenci, C. E.; Uzunalli, G.; Uysal, O.; Yergoz, F.; Umay, E. K.; Guler, M. O.; Tekinay, A. B. (Acta Materialia Inc, 2017)
      Skeletal muscle cells are terminally differentiated and require the activation of muscle progenitor (satellite) cells for their regeneration. There is a clinical need for faster and more efficient treatment methods for ...
    • Oligonucleotide-based label-free detection with optical microresonators: strategies and challenges 

      Toren, P.; Ozgur E.; Bayindir, M. (Royal Society of Chemistry, 2016)
      This review targets diversified oligonucleotide-based biodetection techniques, focusing on the use of microresonators of whispering gallery mode (WGM) type as optical biosensors mostly integrated with lab-on-a-chip systems. ...
    • Regulation of Homer and group I metabotropic glutamate receptors by nicotine 

      Kane, J. K.; Hwang, Y.; Konu, O.; Loughlin, S. E.; Leslie, F. M.; Li, M. D. (Wiley-Blackwell Publishing Ltd., 2005)
      The present study focuses on the nicotine-induced modulation of mRNA and protein expression of a number of genes involved in glutamatergic synaptic transmission in rat brain over different time periods of exposure. A ...
    • Retinal proteins as model systems for membrane protein folding 

      Tastan, O.; Dutta, A.; Booth, P.; Klein-Seetharaman, J. (Elsevier BV, 2014)
      Experimental folding studies of membrane proteins are more challenging than water-soluble proteins because of the higher hydrophobicity content of membrane embedded sequences and the need to provide a hydrophobic milieu ...