Browsing by Keywords "Photodynamic therapy"
Now showing items 1-20 of 33
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Activatable photosensitizers: agents for selective photodynamic therapy
(Wiley-VCH Verlag, 2017)Recent developments in the design of bifunctional and activatable photosensitizers rejuvenate the aging field of photodynamic sensitization and photodynamic therapy. While systematic studies have uncovered new dyes that ... -
A bifunctional photosensitizer for enhanced fractional photodynamic therapy: singlet oxygen generation in the presence and absence of light
(Wiley-VCH Verlag, 2016)The photosensitized generation of singlet oxygen within tumor tissues during photodynamic therapy (PDT) is self-limiting, as the already low oxygen concentrations within tumors is further diminished during the process. In ... -
Chiral Bodipy dyes & photosensitizers for photodynamic therapy and dye-sensitized solar cells
(Bilkent University, 2013)Bodipy is a molecule with many superior properties. After its discovery in 1968, most of the features were not recognized until mid 1990s. Thereafter, many research papers and patents have been produced and the number ... -
Controlled singlet oxygen generation via plasmonic heating of gold nanorods
(Bilkent University, 2015-08)Photodynamic therapy (PDT) is the up-and-coming and developing methodology in order to treat various cancer tissues. The success of therapeutic action is directly related to the presence of cytotoxic singlet oxygen (SO) ... -
Covalently functionalized MSNs as potential photosensitizing agents for PDT
(Bilkent University, 2011)Photodynamic therapy (PDT) is a novel approach for the treatment of some cancers and other non-malignant diseases. PDT aims to kill cancer tissue by the generation of singlet oxygen as a result of excitation of the ... -
Cytotoxicity of multifunctional surfactant containing capped mesoporous silica nanoparticles
(Royal Society of Chemistry, 2016)This paper reports the synthesis of silica capped surfactant (cetyltrimethylammonium bromide; CTAB) and dye (Rose Bengal; RB) containing mesoporous silica nanoparticles (MSNs). Capping the pores of the surfactant containing ... -
Design, synthesis and characterization of activatable photosensitizers for photodynamic therapy
(Bilkent University, 2012)Search for new noninvasive methods for diseases has been significant question for years. Therapeutic properties of light are combined with proper chromophore in order to create fundamentals of photodynamic therapy which ... -
Design, synthesis and characterization of orthogonal bodipy trimers and progress tpwards a singlet oxygen probe
(Bilkent University, 2015-08)Several methods of fighting cancer have been proposed over the years after it was discovered. Photodynamic therapy (PDT) has been part of these methods for many years therefore; too much financial effort has been spent ... -
Designing excited states: theory-guided access to efficient photosensitizers for photodynamic action
(2011)The in silico design of tetraradical S 1 states was validated experimentally through synthesis, followed by characterization including phosphorescence measurements, use of trap molecules, and cell culture studies, leading ... -
Energy transfer, photosensitization and sensing with novel bodipy compounds and their supramolecular assemblies
(Bilkent University, 2017-06)Fluorescent dyes have been used for decades in many applications due to their versatility, sensitivity and many other useful properties. Since their discovery in 1968, BODIPY dyes have come forward and have been used in ... -
An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapy
(TÜBİTAK, 2019)A series of novel BODIPY-bearing electron-withdrawing groups at the meso position are reported here. According to the optical measurements, it may be clearly seen that the introduction of electron-donating groups into ... -
Fluorescence detection of biological thiols and axially chiral bodipy derivatives and alternative methodologies for singlet oxygen generation for photodynamic action
(Bilkent University, 2014)Calorimetric and luminescent detection of biological thiols namely cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) have attracted great interest due to the their biological significance. There are many reported ... -
Generation, storage and delivery of singlet oxygen by a multifunctional agent
(Bilkent University, 2017-04)Photodynamic therapy (PDT) relies on thephoto sensitized generation of sin- glet oxygen (by consuming dissolved oxygen) within tumortissues whose oxygen level is already low enough to make this treatment self-limiting. In ... -
Glycosylated conjugated oligomer and chlorophyll based nanoparticles for photodynamic therapy
(Bilkent University, 2023-01)Nanomaterial-based therapeutic agents are drawing a lot of attention because numerous capabilities, including drugs, targeting groups, and photoactive units, can be combined on one platform to treat infectious diseases and ... -
Imaging of intracellular singlet oxygen with bright BODIPY dyes
(Elsevier Ltd, 2021-04)Singlet oxygen is a cytotoxic reactive species which is involved in the photodynamic therapy of cancer. It is also known to be produced endogenously in most eukaryotic cells and implicated in many biochemical processes, ... -
Molecular logic gates in the activity modulation of potential PDT agents & rational design of selective chloride sensors
(Bilkent University, 2013)Considering the time arrow of science, things are getting smaller and smarter as the information grows immensely. More is known about the molecular and genetic basis of diseases, and therapies become more personalized ... -
Nanostructured materials for biological imaging and chemical sensing
(Bilkent University, 2014-11)In the recent years, the design and synthesis of fluorescent nanoparticles for biological and chemical sensing applications have received considerable attention due to the excellent photostability and emission intensity ... -
Near IR absorbing bodipy-functionalized SPIONs: a potential magnetic nanoplatform for diagnosis and therapy
(De Gruyter, 2014)Photodynamic therapy (PDT), especially with the recent advances in photosensitizer (PS) design, has already been established as a noninvasive technique for cancer treatment. Recently, near-IR-based absorbing PSs that have ... -
Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action
(Wiley-VCH Verlag, 2014)Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high ... -
Non-covalent functionalized SWNTs as delivery agents for novel Bodipy-based potential PDT sensitizers
(2009)Pyrenyl-functionalized distyryl-Bodipy sensitizer attached non-covalently to SWNTs was shown to generate singlet oxygen when excited at 660 nm with a red LED array; this work emphasizes the potential of SWNT as a viable ...
