Browsing by Keywords "Metabolomics"
Now showing items 1-12 of 12
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DORMAN: Database of reconstructed MetAbolic networks
(IEEE, 2021)Genome-scale reconstructed metabolic networks have provided an organism specific understanding of cellular processes and their relations to phenotype. As they are deemed essential to study metabolism, the number of organisms ... -
High-resolution magic anglespinning ¹H nuclear magnetic resonance spectroscopy metabolomics of hyperfunctioning parathyroid glands
(Mosby, Inc., 2016)Background Primary hyperparathyroidism (PHPT) may be related to a single gland disease or multiglandular disease, which requires specific treatments. At present, an operation is the only curative treatment for PHPT. ... -
Identification and targeting of deregulated metabolic pathways in metastatic prostate cancer cells
(Bilkent University, 2023-01)Prostate cancer is the most diagnosed cancer type and the second leading cause of death in men globally. The pathogenesis of prostate cancer mainly relies on the androgen signaling axis. Therefore, androgen deprivation ... -
An integrated genomic and metabolomic approach for defining survival time in adult oligodendrogliomas patients
(Springer, 2019)Introduction The identification of frequent acquired mutations shows that patients with oligodendrogliomas have divergent biology with differing prognoses regardless of histological classification. A better understanding ... -
Matrix Metalloproteinase-11 promotes early mouse mammary gland tumor growth through metabolic reprogramming and increased IGF1/AKT/FoxO1 signaling pathway, enhanced ER stress and alteration in mitochondrial UPR
(MDPI AG, 2020-08)Matrix metalloproteinase 11 (MMP11) is an extracellular proteolytic enzyme belonging to the matrix metalloproteinase (MMP11) family. These proteases are involved in extracellular matrix (ECM) remodeling and activation of ... -
Metabolomic characterization of human hippocampus from drug-resistant epilepsy with mesial temporal seizure
(Wiley-Blackwell Publishing, 2018-03)Within a complex systems biology perspective, we wished to assess whether hippocampi with established neuropathological features have distinct metabolome. Apparently normal hippocampi with no signs of sclerosis (noHS), ... -
Metabolomics approaches in experimental allergic encephalomyelitis
(Elsevier, 2018)A myelin basic protein (MBP)-induced experimental allergic encephalomyelitis (EAE) involves paraplegia due to a reversible thoracolumbar spinal cord impairment. The aims of this study were thus to find significant ... -
Metabolomics approaches in pancreatic adenocarcinoma: Tumor metabolism profiling predicts clinical outcome of patients
(BioMed Central Ltd., 2017)Pancreatic adenocarcinomas (PAs) have very poor prognoses even when surgery is possible. Currently, there are no tissular biomarkers to predict long-term survival in patients with PA. The aims of this study were to (1) ... -
Metabolomics of small intestine neuroendocrine tumors and related hepatic metastases
(MDPI AG, 2019-12)To assess the metabolomic fingerprint of small intestine neuroendocrine tumors (SI-NETs) and related hepatic metastases, and to investigate the influence of the hepatic environment on SI-NETs metabolome. Ninety-four tissue ... -
Predicting carbon spectrum in Heteronuclear Single Quantum Coherence Spectroscopy for online feedback during surgery
(IEEE, 2020)1H High-Resolution Magic Angle Spinning (HRMAS) Nuclear Magnetic Resonance (NMR) is a reliable technology used for detecting metabolites in solid tissues. Fast response time enables guiding surgeons in real time, for ... -
Predicting carbon spectrum in heteronuclear single quantum coherence spectroscopy for online feedback during surgery
(Bilkent University, 2020-09)1H High-Resolution Magic Angle Spinning (HRMAS) Nuclear Magnetic Resonance (NMR) is a reliable technology used for detecting metabolites in solid tissues. Fast response time enables guiding surgeons in real time, for ... -
What does reduced FDG uptake mean in high-grade gliomas?
(NLM (Medline), 2019)Purpose: As well as in many others cancers, FDG uptake is correlated with the degree of malignancy in gliomas, that is, commonly high FDG uptake in high-grade gliomas. However, in clinical practice, it is not uncommon to ...
