Now showing items 1-5 of 5

    • Double bond configuration of palmitoleate is critical for atheroprotection 

      Çimen, I.; Yıldırım, Zehra; Doğan, Aslı Ekin; Yıldırım, Aslı Dilber; Tufanlı, Ö.; Onat, Umut İnci; Nguyen, U.; Watkins, S.; Weber, C.; Erbay, Ebru (Elsevier, 2019)
      Objective Saturated and trans fat consumption is associated with increased cardiovascular disease (CVD) risk. Current dietary guidelines recommend low fat and significantly reduced trans fat intake. Full fat dairy can ...
    • Inflammasome induction and immunostimulatory effects of CpG-ODN loaded liposomes containing DC-cholesterol 

      Bayyurt, B.; Gürsel I. (Turkish Society of Immunology, 2013)
      Objectives: This study aims to investigate the effects of cholesterol content and cationic property of liposomes on immune response. Materials and methods: Liposomes containing high amounts of 3β-[N-(N',N'-dimethylaminoe ...
    • Intercepting the lipid-induced integrated stress response reduces atherosclerosis 

      Onat, Umut I.; Yıldırım, Aslı D.; Tufanlı, Özlem; Çimen, İsmail; Kocatürk, Begüm; Veli, Zehra; Hamid, S.; Shimada, K.; Chen, S.; Sin, J.; Shah, P.; Gottlieb, R.; Arditi, M.; Erbay, Ebru (Elsevier, 2019)
      Background Eukaryotic cells can respond to diverse stimuli by converging at serine-51 phosphorylation on eukaryotic initiation factor 2 alpha (eIF2α) and activate the integrated stress response (ISR). This is a key step ...
    • The role of IRE1 in metaflammation and atherosclerosis 

      Tufanlı, Özlem (Bilkent University, 2017-05)
      Chronic metabolic overloading of anabolic and catabolic organelles such as the endoplasmic reticulum (ER) and mitochondria is a major cause of inflammation in obesity. ER serves as a critical metabolic center for protein, ...
    • The role of lipid-induced integrated stress response in metaflammation and atherosclerosis 

      Onat, Umut İnci (Bilkent University, 2019-07)
      Chronic inflammation resulting from metabolic overloading of organelles (such as the endoplasmic reticulum (ER) and mitochondria that control cellular homeostasis) is a major cause of metabolic disorders including diabetes, ...