Browsing by Keywords "Immune response"
Now showing items 1-11 of 11
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Biosystems engineering of prokaryotes with tumor-killing capacities
(Bentham Science Publishers Ltd., 2016)Certain bacteria selectively attack tumor tissues and trigger tumor shrinkage by producing toxins and modulating the local immune system, but their clinical utility is limited because of the dangers posed by systemic ... -
Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet's disease severity
(Taylor and Francis, 2017-02)Behçet's disease (BD) activity is characterised by sustained, over-exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined. Herein, we show that the human cathelicidin derived ... -
Development of CpG ODN based vaccine adjuvant formulations
(Humana Press, New York, 2016) -
Differential immune activation following encapsulation of immunostimulatory CpG oligodeoxynucleotide in nanoliposomes
(Elsevier, 2011)The immunogenicity of a vaccine formulation is closely related to the effective internalization by the innate immune cells that provide prolonged and simultaneous delivery of antigen and adjuvant to relevant antigen ... -
Encapsulation of two different TLR ligands into liposomes confer protective immunity and prevent tumor development
(Elsevier B.V., 2017)Nucleic acid-based Toll-like receptor (TLR) ligands are promising adjuvants and immunotherapeutic agents. Combination of TLR ligands potentiates immune response by providing synergistic immune activity via triggering ... -
Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy
(Rockefeller University Press, 2007)Specific targets of cellular immunity in human premalignancy are largely unknown. Monoclonal gammopathy of undetermined significance (MGUS) represents a precursor lesion to myeloma (MM). We show that antigenic targets of ... -
Identification of differentially expressed microRNAs during lipotoxic endoplasmic reticulum stress in RAW264.7 macrophages
(Turkish Biochemistry Society, 2016-06)Objective: Increased fatty acids in the circulation and their accumulation in non-adipose tissues play a significant role in the development of obesity related metabolic and inflammatory disorders such as insulin resistance, ... -
Inflammasome induction and immunostimulatory effects of CpG-ODN loaded liposomes containing DC-cholesterol
(Turkish Society of Immunology, 2013)Objectives: This study aims to investigate the effects of cholesterol content and cationic property of liposomes on immune response. Materials and methods: Liposomes containing high amounts of 3β-[N-(N',N'-dimethylaminoe ... -
Investigation of the role of cGAMP in differentiation of T lymphocytes
(Bilkent University, 2016-10)STING is the pivotal mediator for the recognition of host and pathogenic cytosolic dsDNA as well as cyclic di-nucleotides metabolites from microbes. STING can either recognize DNA itself or sense the presence of cGAMP, ... -
Involvement of sting-activating cyclic Di-nucleotides on T-cell differentiation and function: an unresolved issue
(Turkish Society of Immunology, 2016)STING is the pivotal mediator for the recognition of host and pathogenic cytosolic dsDNA as well as cyclic di-nucleotide metabolites from microbes. Studies demonstrated that DNA released from cancerous cells are internalized ... -
Targeting IRE1 with small molecules counteracts progression of atherosclerosis
(National Academy of Sciences, 2017-01)Metaflammation, an atypical, metabolically induced, chronic lowgrade inflammation, plays an important role in the development of obesity, diabetes, and atherosclerosis. An important primer for metaflammation is the persistent ...
