Browsing by Keywords "Hepatoma"

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Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells

Erdal, E.; Ozturk, N.; Cagatay, T.; Eksioglu-Demiralp, E.; Ozturk, M. (Wiley-Liss, Inc, 2005)

We studied in vitro effects of glycogen synthase kinase 3β (GSK3β)-inhibitor lithium on the growth of hepatocellular carcinoma (HCC) cells. Lithium induced strong growth inhibition (>70%) in 75% (n = 9 of 12) of cell ...
p53 but not p16(INK4a) induces growth arrest in retinoblastoma-deficient hepatocellular carcinoma cells

Morel, A. P.; Unsal, K.; Cagatay, T.; Ponchel, F.; Carr, B.; Ozturk, M. (Elsevier, 2000-08)

Background/Aim: Both p16(INK4a) and p53 proteins are negative regulators of the cell cycle. In human hepatocellular carcinomas (HCC), the loss of function of p53, retinoblastoma (pRb) and p16(INK4a) genes by different ...