Browsing by Keywords "Extracellular vesicles"
Now showing items 1-10 of 10
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Characterization of functional and molecular properties of circulating extracellular vesicles of childhood idiopathic nephrotic syndrome patients
(Bilkent University, 2021-10)Nephrotic syndrome (NS) is one of the most common causes of glomerular disease in children and is characterized by the triad of proteinuria, hypoalbuminemia, and edema. The major molecular event in the pathogenesis of NS ... -
Characterization of innate and adaptive immune responses of two rare primary immune deficiencies: CTPS1 and CD55
(Bilkent University, 2019-09)Primary Immune deficiencies (PIDs) are disorders of immune system caused by mutated genes. There are approximately 350 different disorders and each day novel ones are being defined. They can be categorized based on part ... -
Circulating extracellular vesicles of patients with steroid-sensitive nephrotic syndrome have higher RAC1 and induce recapitulation of nephrotic syndrome phenotype in podocytes
(American Physiological Society, 2021-11-09)Since previous research suggests a role of a circulating factor in the pathogenesis of steroid-sensitive nephrotic syndrome (NS), we speculated that circulating plasma extracellular vesicles (EVs) are a candidate source ... -
Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet's disease severity
(Taylor and Francis, 2017-02)Behçet's disease (BD) activity is characterised by sustained, over-exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined. Herein, we show that the human cathelicidin derived ... -
The development of prophylactic and therapeutic vaccine using cell derived extracellular vesicles
(Bilkent University, 2022-08)The primary aim of this thesis is to extend the breadth of in vivo application of externally loaded cell-line derived and tumor derived exosomes as a prophylactic and therapeutic carrier against cancer treatment. Exosomes ... -
Immunotherapeutic action of extracellular vesicles and effects of TLR signaling to immune dysfunction of SCI patients
(Bilkent University, 2017-03)The primary aim of this thesis is to extend the breadth of in vivo application of externally loaded exosomes as prophylactic or therapeutic carriers against disease treatment. Exosomes are secreted from all cells and ... -
Mesenchymal stem cell derived extracellular vesicles: promising immunomodulators against autoimmune, autoinflammatory disorders and SARS-CoV-2 infection
(Scientific and Technical Research Council of Turkey, 2020)Discovery of novel and broad-acting immunomodulators is of critical importance for the prevention and treatment of disorders occurring due to overexuberant immune responseincluding SARS-CoV-2 triggered cytokine storm leading ... -
Regulation of human monocyte differentiation into m1- and m2-like macrophages
(Bilkent University, 2016-05)Myeloid-derived suppressor cells (MDSC) play a key role in down-regulating activated T and NK cells. MDSC are emerging as targets for cancer immunotherapy since they protect tumor cells from immune elimination. We ... -
Therapeutic and diagnostic applications of extracellular vesicles
(Bilkent University, 2016-03)Extracellular vesicles (EV), consisting of exosomes and microvesicles, are secreted biological nanovesicles and assumed plethora of physiological functions ranging from transport of cargo, regulating distant cell communication, ... -
The Yin and Yang of exosome isolation methods: conventional practice, microfluidics, and commercial kits
(Elsevier Inc, 2022-01)Exosomes are a subset of extracellular vesicles released from various cells, and they can be found in different bodily fluids. Exosomes have been utilized as biomarkers to diagnose many diseases and to monitor therapy ...
