Now showing items 1-4 of 4

    • Benzothiazole derivatives as human DNA topoisomerase IIα inhibitors 

      Kaplan-Ozen, C.; Tekiner-Gulbas, B.; Foto, E.; Yildiz I.; Diril, N.; Aki, E.; Yalcin I. (2013)
      Benzothiazole derivatives resembling the structure of DNA purine bases were tested to determine their topoisomerase inhibition activities. Based on DNA topoisomerase I and II relaxation assay results, all 12 derivatives ...
    • Interplay between 15-lipoxygenase-1 and metastasisassociated antigen 1 in the metastatic potential of colorectal cancer 

      Tunçer, S.; Çağatay, T. S.; Keşküş, A. G.; Çolakoğlu, M.; Konu, Ö.; Banerjee S. (Wiley-Blackwell Publishing Ltd., 2016)
      Objectives: Metastasis-associated antigen 1 (MTA1) is implicated in metastasis while 15-lipoxygenase-1 (15-LOX-1) reduces cell motility, when re-expressed in colorectal cancer (CRC). We aimed to understand any potential ...
    • Non-intercalative, deoxyribose binding of boric acid to calf thymus DNA 

      Ozdemir, A.; Gursacli, R. T.; Tekinay, T. (Springer, 2014)
      The present study characterizes the effects of the boric acid binding on calf thymus DNA (ct-DNA) by spectroscopic and calorimetric methods. UV-Vis absorbance spectroscopy, circular dichroism (CD) spectroscopy, transmission ...
    • Spectroscopic evaluation of DNA–borate Interactions 

      Ozdemir, A.; Sarioglu O. F.; Tekinay, T. (Humana Press Inc., 2015)
      We describe the binding characteristics of two natural borates (colemanite and ulexite) to calf thymus DNA by UV–vis absorbance spectroscopy, circular dichroism (CD) spectroscopy, Fourier transform infrared (FT-IR) ...