Browsing by Keywords "Cancer"
Now showing items 1-20 of 26
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Cancer cell Cytotoxicities of 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl) piperazine derivatives
(M D P I AG, 2012)A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5a-g was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and ... -
Cell penetrating peptide amphiphile integrated liposomal systems for enhanced delivery of cargo to tumor cells
(Bilkent University, 2013)Liposomes have been extensively utilized as effective nanocarriers due to their enhanced solubility, higher stability and greater ability to facilitate the slow release of encapsulated drugs compared to free drug ... -
Color graphs for automated cancer diagnosis and grading
(Institute of Electrical and Electronics Engineers, 2010-03)This paper reports a new structural method to mathematically represent and quantify a tissue for the purpose of automated and objective cancer diagnosis and grading. Unlike the previous structural methods, which quantify ... -
Design of a novel MRI compatible manipulator for image guided prostate interventions
(IEEE, 2005-02)This paper reports a novel remotely actuated manipulator for access to prostate tissue under magnetic resonance imaging guidance (APT-MRI) device, designed for use in a standard high-field MRI scanner. The device provides ... -
Enhancer cooperativity as a novel mechanism underlying the transcriptional regulation of E-cadherin during mesenchymal to epithelial transition
(Elsevier, 2015)Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) highlight crucial steps during embryogenesis and tumorigenesis. Induction of dramatic changes in gene expression and cell features is ... -
Exosomes: Natural nanovesicle candidates used in the diagnosis and treatment
(Turkish Society of Immunology, 2013)Exosomes are nano-vesicles released by all known cells. Although they were called as residual cells acting as a cleaner of undesired molecules out of cell during the first discovery in 1980s, recent studies have revealed ... -
Genome-Wide Transcriptional Reorganization Associated with Senescence-to-Immortality Switch during Human Hepatocellular Carcinogenesis
(PLOS ONE, 2013)Senescence is a permanent proliferation arrest in response to cell stress such as DNA damage. It contributes strongly to tissue aging and serves as a major barrier against tumor development. Most tumor cells are believed ... -
Graph embeddings on protein interaction networks
(Bilkent University, 2019-02)Protein-protein interaction (PPI) networks represent the possible set of interactions among proteins and thereby the genes that code for them. By integrating isolated signals on single genes such as mutations or differential ... -
Graph run-length matrices for histopathological image segmentation
(Institute of Electrical and Electronics Engineers, 2011-03)The histopathological examination of tissue specimens is essential for cancer diagnosis and grading. However, this examination is subject to a considerable amount of observer variability as it mainly relies on visual ... -
High school students’ knowledge level of, attitudes toward and interest in cancer
(Bilkent University, 2017-06)Cancer is one of the most common diseases in recent years. However, there are very few studies which investigate adolescents’ cancer awareness and thoughts about cancer in Turkey. This research explored high school students’ ... -
A hybrid classification model for digital pathology using structural and statistical pattern recognition
(Institute of Electrical and Electronics Engineers, 2013)Cancer causes deviations in the distribution of cells, leading to changes in biological structures that they form. Correct localization and characterization of these structures are crucial for accurate cancer diagnosis and ... -
IKBKE inhibits TSC1 to activate the mTOR/S6K pathway for oncogenic transformation
(Scientific and Technical Research Council of Turkey - TUBITAK,Turkiye Bilimsel ve Teknik Arastirma Kurumu, 2018)IKBKE (IKKε) has emerged as a key modulator of multiple substrates, controlling oncogenic pathways in various malignancies. mTOR signaling, required for cellular growth, proliferation, and vascular angiogenesis in cancer, ... -
Malignant-lesion segmentation using 4D co-occurrence texture analysis applied to dynamic contrast-enhanced magnetic resonance breast image data
(2007)Purpose: To investigate the use of four-dimensional (4D) co-occurrence-based texture analysis to distinguish between nonmalignant and malignant tissues in dynamic contrast-enhanced (DCE) MR images. Materials and Methods: ... -
Modules of correlated genes in a gene expression regulatory network of CDDP-resistant cancer cells
(Institute of Electrical and Electronics Engineers, 2018)Chemotherapeutic drugs have been used as important strategies in cancer treatment. However, chemotherapy-resistant tumors arise especially in relapsing and progressive disease. Understanding of mechanisms underlaying ... -
Nanogap based label-free impedimetric biosensors
(Bilkent University, 2012)Despite lots of research going on to find a hope, cancer is still a major cause of death in today‘s world. It has been reported that cancer has some biomarkers in human body and detecting these biomarkers timely can pave ... -
A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells
(Elsevier, 2012)The forward chemogenomics strategy allowed us to identify a potent cytotoxic thiazolidine compound as an apoptosis-inducing agent. Chemical structures were designed around a thiazolidine ring, a structure already noted for ... -
Object-oriented testure analysis and unsupervised segmentation for histopathological images
(Bilkent University, 2012)The histopathological examination of tissue specimens is essential for cancer diagnosis and grading. However, this examination is subject to a considerable amount of observer variability as it mainly relies on visual ... -
Outcomes following total laryngectomy for squamous cell carcinoma: one centre experience
(Elsevier Masson, 2012)Objectives: To evaluate the clinical outcomes of total laryngectomy (TL), complications and factors affecting survival. Design: Retrospective review of hospital electronic database for head and neck squamous cell carcinoma ... -
p53 mutations as fingerprints of environmental carcinogens
(2000)Mutations of the p53 tumor suppressor gene occur in a great majority of human cancers. The protein product of p53 gene is involved in DNA damage response. Consequently, p53 gene may be a preferred target for environmental ... -
Patrolling monocytes control tumor metastasis to the lung
(American Association for the Advancement of Science, 2015)The immune system plays an important role in regulating tumor growth and metastasis. Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical "patrolling" monocytes (PMo) interact with tumors ...
