Browsing by Author "Yağcı, Fuat Cem"
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Bacteriocin DNA nanocomplexes as immunotherapeutic carriers
Yağcı, Fuat Cem; Güçlüler, Gözde; Kıran, F.; Gürsel, İhsan (Association for Cancer Immunotherapy, 2012-05)Synthetic oligodeoxynucleotides (CpG-ODNs) and bacterial DNA containing unmethylated CpG dinucleotides (CpG motifs) are clinical candidates as anti-cancer agents, immune adjuvants, anti-allergens, and stand alone ... -
CpG Oligodeoxynucleotides enhances both humoral and cellular immune responses against FMDV in mice
Yağcı, Fuat Cem; Çokçalışkan, C.; Alkan, M.; Güngör, B.; Gürsel, M.; Gürsel, İhsan (Association for Cancer Immunotherapy, 2012-05)Foot and Mouth Disease is one of the major contagious and devastating viral diseases which is caused by FMD virus (FMDV) of the cloven hoofed animals. FMD outbreaks all around the world caused serious economical losses ... -
Immunotherapeutic applications of nucleic acid based tlr agonists and antagonists
Yağcı, Fuat Cem (Bilkent University, 2014)Recent evidence suggests that genetic material is not just the blueprint of life. Depending on the type of the source that genomic material is extracted or the type of motif that DNA harbors DNA could be immunostimulatory ... -
Suppressive oligodeoxynucleotides as a TLR antagonist : efforts to treat autoimmune diseases
Yağcı, Fuat Cem (Bilkent University, 2007)Synthetic oligodeoxynucleotides (ODN) expressing suppressive TTAGGG motifs effectively down-regulate the production of proinflammatory and Th1 cytokines elicited by a variety of Toll-Like Receptor (TLR) dependent or ...