Now showing items 1-3 of 3

    • Double bond configuration of palmitoleate is critical for atheroprotection 

      Çimen, I.; Yıldırım, Zehra; Doğan, Aslı Ekin; Yıldırım, Aslı Dilber; Tufanlı, Ö.; Onat, Umut İnci; Nguyen, U.; Watkins, S.; Weber, C.; Erbay, Ebru (Elsevier, 2019)
      Objective Saturated and trans fat consumption is associated with increased cardiovascular disease (CVD) risk. Current dietary guidelines recommend low fat and significantly reduced trans fat intake. Full fat dairy can ...
    • Inositol‐requiring enzyme‐1 regulates phosphoinositide signaling lipids and macrophage growth 

      Hamid, S. M.; Çıtır, M.; Terzi, E. M.; Çimen, İ.; Yıldırım, Zehra; Doğan, Aslı Ekin; Kocatürk, B.; Onat, Umut Inci; Arditi, M.; Weber, C.; Traynor‐Kaplan, A.; Schultz, C.; Erbay, E. (Wiley-VCH Verlag, 2020-11)
      The ER‐bound kinase/endoribonuclease (RNase), inositol‐requiring enzyme‐1 (IRE1), regulates the phylogenetically most conserved arm of the unfolded protein response (UPR). However, the complex biology and pathology regulated ...
    • Targeting IRE1 with small molecules counteracts progression of atherosclerosis 

      Tufanli, O.; Akillilar, P. T.; Acosta-Alvear, D.; Kocaturk, B.; Onat, U. I.; Hamid, S. M.; Çimen, I.; Walter, P.; Weber, C.; Erbay, E. (National Academy of Sciences, 2017-01)
      Metaflammation, an atypical, metabolically induced, chronic lowgrade inflammation, plays an important role in the development of obesity, diabetes, and atherosclerosis. An important primer for metaflammation is the persistent ...